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Odontología Vital

On-line version ISSN 1659-0775Print version ISSN 1659-0775


ERAZO PAREDES, Carlos Humberto; RUIZ RAMIREZ, Eliberto; BARREDA TORRES, Oscar Alberto  and  AGUIRRE SIANCAS, Elías Ernesto. Osteoinductive effect of Mineral Trioxide Aggregate versus Portland Cement Type I on mandibular bone lesions. Odontología Vital [online]. 2018, n.28, pp.7-14. ISSN 1659-0775.


An experimental study was carried out to determine the osteoinductive effect of Mineral Trioxide Aggregate (MTA) versus Portland Cement type I on mandibular bone lesions.


Twelve 3-month-old male New Zealand rabbits were divided into 4 equal groups. All rabbits were anesthetized using Pentobarbital. An incision of the mandibular skin was performed to expose the bone on which 3 cavities of 2mm each one were made.

In one cavity MTA was placed, in another Portland Cement type I and the third remained empty. The experimental groups were sacrificed at the 1st, 2nd, 3rd and 4th respective weeks and evaluated histologically by counting osteocytes and osteoblasts.


Both MTA and Portland cement have the same osteoinductive capacity in the 1st, 2nd and 3rd week (0.05 <p). Nonetheless, in the 4th week the MTA had greater osteoinductive capacity by stimulating a greater number of osteoblasts than the Portland Cement (p = 0.024).


The MTA and Portland cement type I showed a similar osteoinductive effect during the first 3 weeks of evaluation, however, MTA had the greatest osteoinductive effect during the fourth week of evaluation.

Keywords : Mineral trioxide aggregate; Portland Cement type I; osteoinduction; osteoblasts; osteocytes.

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