SciELO - Scientific Electronic Library Online

vol.26 issue1Self-medication in patients of cardiovascular health program in a commune in ChilePhysical activity: Effects on physical, social and mental well-being in the population of Goicoechea (Costa Rica) author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links

  • Have no similar articlesSimilars in SciELO


Revista Costarricense de Salud Pública

Print version ISSN 1409-1429


ORDONEZ VARELA, Wendy  and  BLANCO QUIROS, Laura. First isolation of a type KPC-1 carbapenemase-producing Klebsiella pneumoniae strain in the San Carlos Hospital during 2011. Rev. costarric. salud pública [online]. 2017, vol.26, n.1, pp.69-73. ISSN 1409-1429.


To demonstrate the finding of a Klebsiella pneumoniae carbapenemase-1 positive, isolated from a 1-year-old female patient with liver illness and kidney recurrent infections.


Bacterial identification and antimicrobial susceptibility testing was performed with Vitek 2 systems. Phenotypic determination of carbapenemases was performed using boronic acid test and Hodge modified test. Molecular confirmation was done using PCR-RT for gene blaKPC.


Antimicrobial susceptibility testing suggested an extended spectrum betalactamase with reduced sensitivity to carbapenems (imipenem 4 μg/mL, meropenem 1 μg/mL). Boronic acid test and Hodge modified test were consistent with carbapenemase production. Molecular confirmation was positive for carbapenemase-1.


The emergence and spread of carbapenemase-positive strains constitutes a risk for patients and community. These strains are usually resistant to multiple antimicrobials and the resistance mechanisms easily spread. Hospitals are scenarios that favor the spread of these bacteria. Therapeutic options in these cases are reduced, so it is necessary a conscious use of antibiotics, hospital hygiene and interdisciplinary epidemiological surveillance.


It is confirmed the presence of Klebsiella pneumoniae KPC-1, isolated from a girl with urinary tract infection and liver illness. The guidelines of Centro Nacional de Reference en Bacteriology, phenotypic tests and molecular confirmation made possible the confirmation of this finding.

Keywords : Klebsiella pneumoniae; carbapenemases; KPC; drug resistance.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )