SciELO - Scientific Electronic Library Online

vol.39 issue2Battered Child Syndrome: medico-legal aspects and the importance of radiological studies Case reportBeta-amiloid precursor protein ( β-App) and diffuse axonal damage after head injuries: a forensic point of view author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links

  • Have no similar articlesSimilars in SciELO


Medicina Legal de Costa Rica

On-line version ISSN 2215-5287Print version ISSN 1409-0015


LASSO DIAZ, Edgardo; PAVA GARZON, Diana Marcela  and  FLORES RUEDA, Ariel. Pulmonary thromboembolism as a possible adverse reaction to Quetiapine Case report. Med. leg. Costa Rica [online]. 2022, vol.39, n.2, pp.32-36. ISSN 2215-5287.

Some studies suggest a relationship between antipsychotic use and the risk of venous thromboembolism (VTE) and pulmonary embolism (PE). However, the results remain inconclusive. This is the case of a 23-year-old male with a history of schizophrenia and depression treated with quetiapine 800 mg, who was found dead in a hotel bed. At necropsy with no visible traumatic lesions, histological findings of massive pulmonary thromboembolism with secondary pulmonary infarcts. Toxicology laboratory detected the presence of quetiapine, no alcohol or drugs of abuse were detected. Using the Modified Karch & Lasagna Algorithm, pulmonary thromboembolism was an adverse reaction with a probable causal relationship.

Many cases of sudden death caused by PE have been reported with exposure to antipsychotics, but the relationship of their use and the risk of VTE and PE remains controversial.

Keywords : Pulmonary thromboembolism; antipsychotics; quetiapine; adverse reaction.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )