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Medicina Legal de Costa Rica

On-line version ISSN 2215-5287Print version ISSN 1409-0015


CRUZ PEREZ, Francisco; AGUILAR RIVERA, Jeison; RODRIGUEZ MONTERO, Fiorella  and  BARBOZA GAMBOA, Lensy. Antagonistas neurohormonales en el tratamiento de la insuficiencia cardiaca crónica. Med. leg. Costa Rica [online]. 2013, vol.30, n.1, pp.129-133. ISSN 2215-5287.

The chronic heart failure is determined by an important neurohormonal activation that consists in the increase of the sympathetic activation and the renin-angiotensin-aldosterone system. This activation is at the beginning compensatory, but then it leads to a bigger damage of the ventricular function and chronic insufficiency symptoms. The physician must avoid this activation and diminish the progression of the disease. Statins, ACE inhibitor (angiotensin-converting-enzyme inhibitor), angiotensin receptor blockers (ARBs), aldosterone antagonists and beta blockers are the antagonist neurohormonal drugs. All of them have proven to decrease the morbimortality of the disease.

Keywords : Chronic cardiac insufficiency; neurohormonal drugs; ventricular dysfunction.

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