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Revista Tecnología en Marcha

On-line version ISSN 0379-3982Print version ISSN 0379-3982


ARROYO-RODRIGUEZ, Javier et al. Chemogenomics and Chemogenetics: definitions, techniques and applications in the pharmaceutical area. Tecnología en Marcha [online]. 2020, vol.33, n.1, pp.3-16. ISSN 0379-3982.

In the decade of 1980, the science that studied human genome rose strongly, with the purpose of improving human health by identifying genes. These studies allowed the origin of other sciences like Chemogenomics and Chemogenetics. Chemogenomics is an interdisciplinary area that looks for the genome systematization by identifying, analyzing, expanding and predicting the interactions of ligands and proteins using the in vitro and in silico methods. In the other hand, Chemogenetics is the study of the genetic characteristics of a patient to optimize the pharmaceutical therapy and predict the efficacy, the secondary effects and the dosage of certain drugs. The knowledge of molecules and proteins interaction helped to develop new biotechnological tools and to identify novel drug targets that could conduct to more specific knowledge. One of the applications in Pharmacy are the designer receptors exclusively activated by designer drugs (DREADDs). The DREADDs may not allow the activation by the endogenous ligands, but in presence of endogenous ones. Actually, there are lots of investigations in which DREADDs are being studied for the identification of neurons and signalization routes involved in pathologies such as fear, anxiety, depression, addiction, and obesity.

Keywords : Biotechnology; Pharmacogenomics; Pharmacogenetics; Pharmacy; DREADDs.

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