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Revista Costarricense de Ciencias Médicas

Print version ISSN 0253-2948


BARQUERO-QUIROS, Miriam; VARGAS-ROJAS, Rosario  and  BLANCO-SAENZ, Rigoberto. Neurotoxicidad y enfermedades óseas provocadas por la contaminación con aluminio de soluciones de diálisis renal. Rev. costarric. cienc. méd [online]. 2001, vol.22, n.3-4, pp.179-189. ISSN 0253-2948.

This article reviews the principal evidences about aluminum neurotoxicity in vitro, and some evidences in brain tissues of Alzheimer patients; and also show some studies realized with humans that suffer renal deficiencies, dealing with the principal osteodystrophy. The problem of analyzing low aluminum concentration in human fluids is overcomed with very sensitive analytical methods as Electrothermal Atomic Absorption Spectrometry (ETAS) and voltammetric methods as Anodic Striping Voltammetry with complexing agents that easing adsorption over solid electrodes or mercury hanging drop. Is a vital question to know with accuracy the aluminum concentration in water used in hemodialysis or in fluids used in ambulatory peritoneal dialysis, as a first stage to prevent contamination by aluminium. So the prevention of contamination during sampling, storage and analysis of biological fluids should be the first need and the sources of water used in renal dialysis keep be as clean as possible of aluminium contamination.

Keywords : content aluminum; renal dialysis; osteodystrophy; neurotoxicity; Alzehimer; analysis.

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