SciELO - Scientific Electronic Library Online

vol.22 issue1-2La exposición a ozono disminuye la adherencia y aumenta la permeabilidad de membrana de macrófagos alveolares de rataUn método rápido de reprocesamiento para microscopia electrónica de cortes histológicos en parafina author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links

  • Have no similar articlesSimilars in SciELO


Revista Costarricense de Ciencias Médicas

Print version ISSN 0253-2948


GRANADOS-ZUNIGA, Jorge. Determinación de ciclosporina sanguínea realizada en el Hospital San Juan de Dios, San José, Costa Rica. Rev. costarric. cienc. méd [online]. 2001, vol.22, n.1-2, pp.45-50. ISSN 0253-2948.

Cyclosporine and metabolites (maded by FPIA Abbott TDx) and cyclosporine (maded by FPIA Abbott AxSyM) blood levels were assayed on 86 renal transplanted adult patients of any sex. Results were 3.26 times greater with TDx than with AxSyM (range=1,02-6,01, SD=0,99). That may be attributed to TDx antiserum cross-reactivity with cyclosporine metabolites. The wide variability in TDx/AxSyM rates (1,02-6,01) could be caused by interindividual differences on P-450 cytocrom-enzyme activities. It is suggested that differences in methods may require adjustments in therapeutic ranges.

Keywords : drug monitoring; cyclosporine; kidney transplant.

        · abstract in Spanish     · text in Spanish