SciELO - Scientific Electronic Library Online

vol.20 issue1-2Distribución de los fenotipos y genotipos de sistema Kell en la población de Costa RicaEl uso adecuado de protectores solares en Costa Rica author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links

  • Have no similar articlesSimilars in SciELO


Revista Costarricense de Ciencias Médicas

Print version ISSN 0253-2948


PIZARRO-CERDA, Javier. Asociación de patógenos bacterianos a células eucariotas: el caso de parasitismo intracelular de brucella abortus. Rev. costarric. cienc. méd [online]. 1999, vol.20, n.1-2, pp.85-102. ISSN 0253-2948.

Brucella abortus is an intracellular parasite that infects a broad range of mammals, including humans. This bacterium promotes its own internalization in epithelial celis inducing local cytoskeletal rearrangements. Within the intracelular space, Brucella locates initially to an early compartment of the endocytic/phagocytic cascade; however, the pathogen rapidly escapes from this intracellular pathway and associates to the autophagocytic cascade. During the late stages of infection, Brucella proliferases within the endoplasmic reticulum of infected celis. Brucellae posses a system for the regulated transcription of virulence genes that includes a sensor transmembrane protein and a cytoplasmic regulatory protein: this two-component regulatory complex allows the bacteria to adapt to the different microenvironments that the parasite confront at each step during the process of intracelular infection. These biological properties might favor the use of Brucella abortus as a recombinant vaccinal vector.

Keywords : Parasite; lntracellular trafficking; Phagosome; Autophagocytosis; Endoplasmic reticulum; Regulatory system; Lipopolysaccharide; Cationic peptides; Recombinant vaccine.

        · abstract in Spanish     · text in Spanish