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Revista de Biología Tropical

On-line version ISSN 0034-7744Print version ISSN 0034-7744


GARCIA GONZALEZ, Mildred; COTO MORALES, Teresita; SOTO RODRIGUEZ, Gerardo A  and  PAZOS, Liliana. Toxicidad sub-crónica y prueba de irritabilidad ocular del extracto acuoso de las hojas de Plantago major (Plantaginaceae). Rev. biol. trop [online]. 2003, vol.51, n.3-4, pp.635-638. ISSN 0034-7744.

For the sub-chronic toxicity an aqueous preparation of Plantago major leaves was tested in 20 male NGP mice, with an average weight of 20.15 g and separated in two groups of ten individuals each. The dose used was 2000 mg/kg and the control group received 0.5 ml of distilled water. The extract administration was done daily during five days at week for a total period of 40 days. Signs of sub-chronic toxicity were observed in the days two and 12 of treatment. No significant change in corporal weight was observed. The ocular irritation was tested in five New Zeland male rabbits, with an average weight of 3.640 kg. The dose used was a 200 µl the preparation (100 mg/ml) of Plantago major leaves, instill into the right eye and the control was used the left eye instill 200 µl of distilled water. The administration was done daily during five days. The extract shows no significant irritation during the observation period

Keywords : Plantago major; Plantaginaceae; sub-chronic toxicity; irritation ocular; herbal medicine; llantén.

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