SciELO - Scientific Electronic Library Online

vol.47 issue4Aporte de hojarasca y renovación foliar del manglar en un sistema estuarino del Sureste de México author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links


Revista de Biología Tropical

On-line version ISSN 0034-7744Print version ISSN 0034-7744


BADILLA, Beatriz; MORA, Gerardo  and  POVEDA, Luis Jorge. Anti-inflammatory activity of aqueous extracts of five Costa Rican medicinal plants in Sprague-Dawley rats. Rev. biol. trop [online]. 1999, vol.47, n.4, pp.723-727. ISSN 0034-7744.

The anti-inflammatory properties of Loasa speciosa and Loasa triphylla (Loasaceae), Urtica leptuphylla and Urera baccifera (Urticaceae), and Chaptalia nutans (Asteraceae) were studied using the carregeenan induced rat paw edema model. Aqueous extracts of each plant were made according to the ethnobotanical use. The hippocratic assay was made with female rats; the dose used was 500 mg/kg i.p. and the control group received 0.5 ml of n.s.s.. All the animals treated showed hipothermia, and those treated with the extracts of Chaptalia nutans, Urera baccifera and Urtica leptuphylla showed an increased colinergic activity. Acute toxicities of the aqueous extracts were studied in mice an the mean lethal doses ranged between 1.0226 and 1.2022 g/kg. The extracts of Urera baccifera, Chaptalia nutans, Loasa speciosa and Loasa triphylla (500 mg/kg i.p.) showed an anti-inflammatory activity comparable with that of indomethacin. The extracts of U. baccifera and C. nutans, which showed the greatest anti-inflammatory activity, did not show it when used orally (500 mg/kg p.o.).

Keywords : Medicinal plants; anti-inflammmatory agent; edema; Urticaceae; Asteraceae; Loasaceae.

        · text in English


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License