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Acta Médica Costarricense

On-line version ISSN 0001-6002Print version ISSN 0001-6012


NAVARRO-SOLANO, Jonatan  and  CHEN-KU, Chih Hao. Update of the effect of antihyperglycemic agents on renal function in type 2 diabetes mellitus. Acta méd. costarric [online]. 2018, vol.60, n.2, pp.6-14. ISSN 0001-6002.

Type 2 diabetes mellitus is one of the metabolic diseases that affects different organs, one of which is the kidney. One of the main microvascular complications is diabetic nephropathy, being the main cause of chronic renal failure worldwide. Hence the importance of recommendations on the use or non-use of antihyperglycemic drugs based on their beneficial effects on kidney function, expressed by the estimated glomerular filtration rate and the albumin / creatinine ratio in patients with type 2 diabetes mellitus and kidney disease. Recent studies have shown antihyperglycemic agents with beneficial impact in cardiovascular and renal endpoints. In the present article we will review the actions and effects of different groups of drugs such as metformin, inhibitors of dipeptidyl peptidase 4, GLP-1 agonists, thiazolidinediones, sulfonylureas, SGLT-2 inhibitors and insulins in renal function in relation to the doses of each drug, both the use of established doses, reduction of the dose or non-use of the drug based on the worsening of the estimated glomerular filtration rate. With respect to the methodology applied for the development of the article, a selection of articles was made based on key words such as type 2 diabetes mellitus, antihyperglycemic agents in renal function, estimated glomerular filtration rate and albumin/ creatinine ratio. Prestigious journal articles were used with less than 5 years since its publication, however articles that exceed this time were used as they provided important data in the review article.

Keywords : Diabetes mellitus type 2; Diabetic nephropathy; IDPP-4; ISGLT2; Metformin; thiazolidinediones; sulphonylureas; insulin; glomerular filtration rate; GLP-1 analogs.

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