Abstract

CHAVEZ B, Liliana; SOLAZAR, Lisbeth; BRILLA S, Alfredo  and  HERRMANN, F H.. Estudio de factores trombogénicos en pacientes menores de 45 años con infarto del miocardio. Rev. costarric. cardiol [online]. 2002, vol.4, n.3, pp.05-10. ISSN 1409-4142.

lntroduction: The study was orientated towards finding thrombophylia in young patients with genetic myocardium infarct as with anticoagulant proteins. Material and Methods: The lab Test used for the fibrinogen was the Clauss Method, for the C protein and ATIII a chromogenic method was used, for the S protein a coagulometrical method and for the genetic testing, PCR. Fifty one young patients were chosen (under 45 years of age) with acute myocardium infarct and 43 healthy patients in the control group in the same age range. Results: An 85% of the patients were male and 15% female. The variable that was a statistically significant risk factor was the gender (P= 0.0023) showing that for every 4.19 men that suffer an infarct there is one woman. The body mass index was substantially higher with infarcted patients (P=0.002733) which had a statistical significant association with coronary obstructions. Hypertension was also statistically significant (P = 0.00167). Mean value for total cholesterol was 166mg/dl in healthy patients versus 213mg/dl with infarcted patients (P = 0.000527mg/dl). A 78% of patients with infarct had HDL cholesterol levels of 35mg/dl or lower and showed a statistically significant association with coronary obstructions. Triglycerides levels also showed a statistically significant association (P= 0.0001 61 mg/dl). A 58% of patients with infarct showed high levels of LDL cholesterol. The analysis of anticoagulant proteins in the sick group resulted in lower levels of S and C versus the control group. Analyzing the crosses, there is a statistically significant association between the allelic frequencies in the mutation of the MTHFR enzyme and having normal levels of C and S protein in the healthy as well as in the control group. There was no statistical significant association in the for the Leyden V factor and the 20210 prothrombin factor variable.

Keywords : Thrombosis; infarct; anticoagulant proteins and genetic factors.