Abstract

SOTO-BERNARDINI, María Clara  and  RAVENTOS-VORST, Henriette. The role of oxidative stress in schizophrenia. Acta méd. costarric [online]. 2008, vol.50, n.4, pp.197-202. ISSN 0001-6002.

Schizophrenia is a severe mental disorder that affects approximately 1% of the population worldwide. Genetic and environmental factors are important in its etiology, so the risk genotype increases the susceptibility to manifest the disorder. There is evidence that the balance between the production of free radicals and the antioxidant defense system is abnormal in schizophrenia patients. Nonetheless, it is not known if it plays a causal role in the development of the disorder, or if it is produced during the course of the disease, or as a consequence of antipsychotic treatment. In this paper, we review the evidence of the participation of these substances in the development of the illness.

Keywords : oxidative stress; schizophrenia; oxyradicals; antioxidant defense system.

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