Abstract

QUINTANILLA-GALLO, Júvel; MARCHENA- PICADO, Margarita  and  GOURZONG- TAYLOR, Charles. Síndrome aglutininas frías. Acta méd. costarric [online]. 2004, vol.46, n.4, pp.204-207. ISSN 0001-6002.

The cold agglutinin syndrome is an uncommon disorders described more than one century ago. Red blood cells are lysed by complement and undergo phagocytosis by the reticulum endothelial system at low temperatures. We report the case of an 80 year old woman who suffered anemia and respiratory symptoms, treated with antibiotics on ambulatory basis. Her laboratory data showed a high titer of IgM cold agglutinins (1:8192). This disorder may be idiopathic, but secondary forms are seen in patients with Mycoplasma infection or malignant hematological neoplasm. We discuss this syndrome as well as its pathophysiology, clinical presentation, laboratory studies and treatment

Keywords : aglutininas frías; anemia hemolítica autoinmune; anticuerpos fríos; síndrome aglutininas frías.