Resumo

DEL VALLE LANZA CASTILLO, Vilma; MARCHAN GOMEZ, Magdielis Saraí; RIVAS PATINO, Lismary José  e  HENRIQUEZ GUZMAN, William Celestino. Chemical screening and biological activity of extracts from Ficus pumilaMoraceae) and Phthirusa stelis (Loranthaceae). Cuadernos de Investigación UNED [online]. 2024, vol.16, n.1, pp.28-38. ISSN 1659-4266.  http://dx.doi.org/10.22458/urj.v16i1.5008.

Introduction: The plants Ficus pumila and Phthirusa stelis are emerging as natural product sources. Objectives: To identify chemical compounds, antibacterial and antifungal activity, and toxicity against Artemia sp. and Aedes aegypti larvae. Methods: We tested methanol and propanol extracts from fruits, leaves, and stems. Results: F. pumila had flavonoids, tannins, and polyphenols; P. stelis had flavonoids, tannins, anthraquinones, triterpenes, and polyphenols. The isopropanol stem and ethanol leaf extracts of F. pumila showed significant antibacterial activity, the former a 10mm zone of inhibition against B. subtilis; the latter, 11 mm against S. aureus. The ethanol leaf and stem extracts of P. stelis had inhibition against S. aureus and B. subtilis: 10mm each the leaf; 11 and 10mm, respectively, the stem. The isopropanol leaf extract of P. stelis was also highly effective against E. coli (15mm). Most extracts were cytotoxic against Artemia sp.; ethanol and propanol leaf extracts of P. stelis had positive LC50 values, particularly the propanol leaf and stem extracts of P. stelis (0,01 and 0,02L/mL); the ethanol leaf extract of P. stelis (0,01L/mL) and the propanol fruit extract of F. pumila. None of the extracts inhibited fungal growth or affected A. aegypti larvae. Conclusion: F. pumila and P. stelis have potential for therapeutic use.

Palavras-chave : Probit; Logit; pharmacologicals; natural products; bioactive compounds.

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