Abstract

SALAZAR-SANCHEZ, Lizbeth et al. Common polymorphisms and cardiovascular factors in patients with myocardial infarction of Costa Rica. Rev. biol. trop [online]. 2006, vol.54, n.1, pp.1-11. ISSN 0034-7744.

Eight common polymorphisms of known myocardial infarction (MI)risk factors (factor V Leiden (FVL), factor V HR2 (FVHR2),factor II 20210G>A (FII),factor VII IVS7 (FVII IVS7),factor VII Arg353Gln (FVII), factor XIII Val34Leu (FXIII),Methylenetetrahydrofolate reductase C677T (MTHFR), Angiotensin Converting Enzyme (ACE))and environmental risk factors were analyzed in a MI patients of Costa Rica.This case-control study included 186 MI subjects,95 of them <45 years and 201 age and sex matched controls.With the use of PCR method the polymorphisms were detected and through interviews additional information was collected.Hypercholesterolemia and smoking were associated with a significant risk in younger patients.High fibrinogen level was an important risk factor and interaction with smoking was detected.Mainly,the genotype 34LeuLeu of FXIII showed significant protective effect,(OR 0.32,95%CI 0.13-0.80)while the other polymorphisms showed no significant difference between the cases and the controls.Carriers of FVII (OR 2.75,95%CI 1.07-7.02)and FXIII (OR 4.20,95%CI 2.03-8.67)polymorphisms showed interaction with fibrinogen in the sta- tistical analysis.It was concluded that there was an important interaction between the common risk factors and the polymorphisms (FVII;FXIII)in the development of MI.This is one of the first reports in a Latin-American population dealing with these molecular markers and MI.Rev.Biol.Trop.54(1):1-11.Epub 2006 Mar 31.

Keywords : Arterial thrombosis; myocardial infarction; polymorphisms; fibrinogen; Latin-American.

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