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Acta Médica Costarricense

versão On-line ISSN 0001-6002versão impressa ISSN 0001-6012


CERNA-ARROYO, Allan et al. Clinical, epidemiological and therapeutic profile of pediatric Wilms tumor in Costa Rica. Acta méd. costarric [online]. 2020, vol.62, n.3, pp.113-118. ISSN 0001-6002.


Wilms tumor is the most frequent malignant renal tumor in pediatrics. Therapeutic management follows the oncological principle of curing the disease through surgery, chemotherapy, radiotherapy. It seeks to minimize the toxicity of treatments. The objective of the study was todescribe the clinical, epidemiological and, therapeutic characteristics of patients diagnosed with Wilms tumor, treated at the Oncology Unit of the National Children’s Hospital “Dr. Carlos Sáenz Herrera” CajaCostarricense de Seguro Social, during the period from January 2009 to December 2016.


It is a descriptive, observational, retrospective study of one series of cases. The population analyzed were 42 pediatric patients with Wilms tumor for seven years. Medical records were revised retrospectively to collect data about all cases. The statistical analysis used qualitative variables and quantitative variables to descriptive and inferential techniques, and for survival analysis, Kaplan- Meier survival curves were used.


During a study period, a total of 42 patients diagnosed with Wilms tumor were studied. 59.5% were women. The prevalence is higher in children 2 years old or younger (66.7%). 95.2% of the patients presented favorable histology; and when discriminated by sex, 100.0% of unfavorable histology were women. The most common surgery was nephrectomy. All patients received chemotherapy and 38.1% radiotherapy. The main acute side effect of radiotherapy was vomiting. The estimated overall survival was 85.6% at 3 years, and 79.9% at 5 years and the disease-free survival was the same as 78.8% at 3 and 5 years.


Wilms tumor exhibited low frequency in pediatric patients, in both sexes however bad histology most affected women. The patient received a combination of therapy with surgery, chemotherapy and, radiotherapy; his interventions have success and pediatric patients have longer overall survival and free disease progression survival at 5 years, like results of other average income countries.

Palavras-chave : Wilms tumor; pediatrics; clinical; epidemiology; treatment; radiotherapy..

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