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Acta Médica Costarricense

versão On-line ISSN 0001-6002versão impressa ISSN 0001-6012


CASTRO-PIEDRA, Silvia E.  e  ARIAS-VARELA, Karla A.. Platelet rich plasma update. Acta méd. costarric [online]. 2019, vol.61, n.4, pp.142-151. ISSN 0001-6002.

Platelet-rich plasma is a blood-derived product, rich in peptides and intercellular signaling proteins and cytokines capable of intervening in each stage of the regeneration of various tissues. Mainly, it has been attributed anti-inflammatory effects in different lesions, as well as other biological effects on cells and tissues. To date, there is no standard production or preparation protocol, nor has a specific dose been described. The form of application is very variable and depends on the condition to be treated. Despite this, positive effects have been seen in different fields such as: dentistry, orthopedics, dermatology, reconstructive medicine, ophthalmology, sports medicine, vascular medicine among others. Its regulation is very diverse internationally. Although there is a lot of expectation with the treatment of platelet-rich plasma, there are not enough robust clinical trials that provide a high level of evidence to validate it as a routine treatment for a certain clinical condition. In addition, the results of different investigations cannot be easily compared due to the variability in the method of preparation and the lack of homogeneity in the treated lesions, among other factors. It is for this reason that it is necessary to develop more serious investigations that lead to the establishment of a standardized protocol, as well as to demonstrate the effectiveness of this new treatment and culminate with the implementation of new validated and authorized therapies to guarantee a real improvement to the patients.

Palavras-chave : platelet-rich plasma; peptides and intercellular signaling proteins; dermatology; regeneration; musculoskeletal system..

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