<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1409-0015</journal-id>
<journal-title><![CDATA[Medicina Legal de Costa Rica]]></journal-title>
<abbrev-journal-title><![CDATA[Med. leg. Costa Rica]]></abbrev-journal-title>
<issn>1409-0015</issn>
<publisher>
<publisher-name><![CDATA[Asociación Costarricense de Medicina Forense]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1409-00152016000100262</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[La Tosferina: Un acercamiento a sus últimas investigaciones]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Quirós González]]></surname>
<given-names><![CDATA[Gabriela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Solano Tenorio]]></surname>
<given-names><![CDATA[Natalia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Área de Salud Guatuso  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<aff id="Af2">
<institution><![CDATA[,Área de Salud Belén - Flores  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2016</year>
</pub-date>
<volume>33</volume>
<numero>1</numero>
<fpage>262</fpage>
<lpage>268</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_arttext&amp;pid=S1409-00152016000100262&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_abstract&amp;pid=S1409-00152016000100262&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_pdf&amp;pid=S1409-00152016000100262&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: La Tosferina es una infección respiratoria causada por Bordetella pertussis, la cual se caracteriza por paroxismos de tos persistente y sofocantes durante varias semanas. A pesar de ser una enfermedad inmunoprevenible, sigue siendo una causa importante de morbilidad y mortalidad en recién nacidos y lactantes, quienes sufren los cuadros más graves; razón por lo cual esta enfermedad no deja de preocupar a las autoridades sanitarias. En este artículo, se hará una revisión del tema con respecto a su etiología, clínica, diagnóstico, tratamiento y prevención. Así mismo, se hará referencia a la situación epidemiológica de dicha enfermedad en Costa Rica.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract: Whooping cough is a respiratory infection caused by Bordetella Pertussis, characterized by a persistent and suffocating cough which lasts several weeks. Although the disease is preventable, it continues to be an important cause of morbidity and mortality in newborns and infants in whom the clinical course is more serious, and therefore remains a concern for health care officials. This article will review the topic examining etiology, clinical course, diagnostics, treatment, and prevention, making reference to the situation in Costa Rica]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Tosferina]]></kwd>
<kwd lng="es"><![CDATA[Bordetella Pertussis]]></kwd>
<kwd lng="es"><![CDATA[Vacuna contra Pertussis]]></kwd>
<kwd lng="en"><![CDATA[Whooping Cought]]></kwd>
<kwd lng="en"><![CDATA[Bordetella Pertussis]]></kwd>
<kwd lng="en"><![CDATA[Pertussis Vaccine]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Arbolave]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Actualización en Tosferina]]></article-title>
<source><![CDATA[Pediatria Integral]]></source>
<year>2014</year>
<volume>XVIII</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>101-7</page-range></nlm-citation>
</ref>
<ref id="B2">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Avila]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Morice]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Chanto]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Bolaños]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Campos]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Salazar]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Morera]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<source><![CDATA[Protocolo de vigilancia epidemiológica Tosferina]]></source>
<year>2009</year>
<month>,</month>
<publisher-loc><![CDATA[San José, CR ]]></publisher-loc>
<publisher-name><![CDATA[MS]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B3">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chanto]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Lara]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Vigilancia de laboratorio de la tosferina en Costa Rica, 2014]]></article-title>
<source><![CDATA[Boletín Inciensa]]></source>
<year>2014</year>
<month>,</month>
<volume>26</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>23-4</page-range></nlm-citation>
</ref>
<ref id="B4">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cofré]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Tos Ferina]]></article-title>
<source><![CDATA[Meneghello Pediatría]]></source>
<year>2013</year>
<edition>6</edition>
<page-range>697-701</page-range><publisher-loc><![CDATA[Chile ]]></publisher-loc>
<publisher-name><![CDATA[Panamericana]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B5">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cornia]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Lipsky]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<source><![CDATA[Bordetella Pertussis Infection: Epidemiology, microbiology, and pathogenesis]]></source>
<year>2014</year>
<publisher-name><![CDATA[Uptodate]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B6">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Crowcrof]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Stein]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Duclos]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Birmingham]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[How best to estimate the global burden of pertussis?]]></article-title>
<source><![CDATA[Lancet infectious diseases]]></source>
<year>2003</year>
<volume>3</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>413-8</page-range></nlm-citation>
</ref>
<ref id="B7">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Durán]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Monge]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Herrera]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Gamboa]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Tosferina, una enfermedad prevalente]]></article-title>
<source><![CDATA[Medicina Legal de Costa Rica]]></source>
<year>2013</year>
<volume>30</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>123-8</page-range></nlm-citation>
</ref>
<ref id="B8">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Halperin]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Tosferina y otras infecciones por Bordetella]]></article-title>
<source><![CDATA[Harrison, Principios de Medicina Interna]]></source>
<year>2009</year>
<edition>17</edition>
<page-range>933-6</page-range><publisher-loc><![CDATA[México ]]></publisher-loc>
<publisher-name><![CDATA[McGrawHill]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B9">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hamborsky]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Kroger]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Wolfe]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<source><![CDATA[Centers of Disease Control and Prevention. Epidemiology and Prevention of Vaccine - Preventable Diseases]]></source>
<year>2015</year>
<edition>13</edition>
<publisher-loc><![CDATA[Washington, USA ]]></publisher-loc>
<publisher-name><![CDATA[Public Health F]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B10">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Marcdante]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Kliegman]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Jenson]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Behrman]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<source><![CDATA[Síndrome Coqueluchoide. En Nelson: Pediatría Escencial]]></source>
<year>2011</year>
<edition>6</edition>
<page-range>395-7</page-range><publisher-loc><![CDATA[España ]]></publisher-loc>
<publisher-name><![CDATA[Elsevier Saunders]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B11">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[McMillan]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Feigin]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[De Angelis]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Jones]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<source><![CDATA[Oski&#8217;s Pediatrics: Principles &amp; Practice]]></source>
<year>2006</year>
<edition>4</edition>
<publisher-loc><![CDATA[España ]]></publisher-loc>
<publisher-name><![CDATA[Lippincott Williams &amp; Wilkins]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B12">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Moreno]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Baquero]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Tos ferina. Protocos diagnóstico - Terapeúticos de la AEP]]></article-title>
<source><![CDATA[Infectología Pedíatrica]]></source>
<year>2013</year>
<page-range>95-102</page-range></nlm-citation>
</ref>
<ref id="B13">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Quian]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Tos ferina: vieja enfermedad, nuevos desafios]]></article-title>
<source><![CDATA[Biomedicina]]></source>
<year>2012</year>
<volume>7</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>22-7</page-range></nlm-citation>
</ref>
<ref id="B14">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Snyder]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Fisher]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Pertussis in Childhood]]></article-title>
<source><![CDATA[Pediatrics in Review]]></source>
<year>2012</year>
<volume>33</volume>
<page-range>412-21</page-range></nlm-citation>
</ref>
<ref id="B15">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ulloa]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Estrategias actuales de vacunación contra tos ferina en niños y adultos]]></article-title>
<source><![CDATA[Acta Pediátrica Costarricense]]></source>
<year>2008</year>
<volume>20</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>81-7</page-range></nlm-citation>
</ref>
<ref id="B16">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zúñiga]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Sánchez]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Fernández]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Ramírez]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Salazar]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Arroba]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<source><![CDATA[Norma Nacional de Vacunación]]></source>
<year>2013</year>
<publisher-loc><![CDATA[San José, CR ]]></publisher-loc>
<publisher-name><![CDATA[Ministerio de Salud]]></publisher-name>
</nlm-citation>
</ref>
</ref-list>
</back>
</article>
