<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1409-0015</journal-id>
<journal-title><![CDATA[Medicina Legal de Costa Rica]]></journal-title>
<abbrev-journal-title><![CDATA[Med. leg. Costa Rica]]></abbrev-journal-title>
<issn>1409-0015</issn>
<publisher>
<publisher-name><![CDATA[Asociación Costarricense de Medicina Forense]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1409-00152016000100197</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Aspectos Farmacocinéticos a Tomar en Cuenta Durante la Prescripción de Fármacos en el Embarazo]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ávila Darcia]]></surname>
<given-names><![CDATA[Sergio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Solís Flores]]></surname>
<given-names><![CDATA[William]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Caja Costarricense del Seguro Social Área de Salud Horquetas ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<aff id="Af2">
<institution><![CDATA[,Área de Salud Montes de Oca Área de Salud Montes de Oca CCSS-UNIBE]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2016</year>
</pub-date>
<volume>33</volume>
<numero>1</numero>
<fpage>197</fpage>
<lpage>204</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_arttext&amp;pid=S1409-00152016000100197&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_abstract&amp;pid=S1409-00152016000100197&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_pdf&amp;pid=S1409-00152016000100197&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: El embarazo es un estado dinámico durante el cual se presentan diversos cambios considerados como fisiológicos. Un alto porcentaje de mujeres utiliza fármacos durante su embarazo, ya sea este un tratamiento crónico o agudo, por lo que resulta de vital importancia conocer los aspectos farmacocinéticos que podrían tener lugar en el cuerpo debido a los cambios anteriormente mencionados. Un dato esencial a tomar en cuenta y único del estado grávido es la existencia de la unidad feto-placentaria, la cual representa un compartimento aparte con un comportamiento farmacocinético distinto. A continuación se presentará una revisión de los principales cambios farmacocinéticas durante el embarazo que se conocen en la actualidad, lo que nos permitirá mantener un juicio más crítico ante la prescripción de medicamentos en la mujer embarazada.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract: Pregnancy is a dynamic state during which many changes considered as physiological take place. A high percentage of women use some kind of medication during pregnancy, whether it is chronic or acute treatment, so it is vital to know the pharmacokinetic aspects that could take place in the body due to the changes previously mentioned. An essential fact to consider and unique of the gravid state is the existence of the placental-fetal unit, which represents a separate compartment with a different pharmacokinetic behavior. Below, there is a review of the main pharmacokinetic changes during pregnancy that are known until now, which will allow us to maintain a more critical judgement before prescribing drugs in pregnant women.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Farmacocinética]]></kwd>
<kwd lng="es"><![CDATA[Fármacos]]></kwd>
<kwd lng="es"><![CDATA[Embarazo]]></kwd>
<kwd lng="es"><![CDATA[Unidad Feto Placentaria]]></kwd>
<kwd lng="en"><![CDATA[Pharmacokinetics]]></kwd>
<kwd lng="en"><![CDATA[Drugs]]></kwd>
<kwd lng="en"><![CDATA[Pregnancy]]></kwd>
<kwd lng="en"><![CDATA[Maternal Placental Fetal Unit]]></kwd>
</kwd-group>
</article-meta>
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<article-title xml:lang=""><![CDATA[Structure function relationships in the lymphatic system and implications for cancer biology]]></article-title>
<source><![CDATA[Cancer Metastasis Review]]></source>
<year>2006</year>
<volume>25</volume>
<page-range>159-84</page-range></nlm-citation>
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</ref-list>
</back>
</article>
