<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0379-3982</journal-id>
<journal-title><![CDATA[Revista Tecnología en Marcha]]></journal-title>
<abbrev-journal-title><![CDATA[Tecnología en Marcha]]></abbrev-journal-title>
<issn>0379-3982</issn>
<publisher>
<publisher-name><![CDATA[Instituto Tecnológico de Costa Rica]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0379-39822015000500046</article-id>
<article-id pub-id-type="doi">10.18845/tm.v28i5.2219</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Sustitutos e injertos de piel desarrollados por ingeniería de tejidos]]></article-title>
<article-title xml:lang="en"><![CDATA[Skin grafts and substitutes developed by Tissue Engineering]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Chaves-Rodríguez]]></surname>
<given-names><![CDATA[María Inés]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Calvo-Castro]]></surname>
<given-names><![CDATA[Laura A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Alvarado-Meza]]></surname>
<given-names><![CDATA[Ricardo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Madrigal-Monge]]></surname>
<given-names><![CDATA[Olman]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ulloa-Fernández]]></surname>
<given-names><![CDATA[Andrea]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Centeno-Cerdas]]></surname>
<given-names><![CDATA[Carolina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Tecnológico de Costa Rica Escuela de Biología Centro de Investigación en Biotecnología]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Costa Rica</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto Tecnológico de Costa Rica Escuela de Biología Centro de Investigación en Biotecnología]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Costa Rica</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Laboratorio Nacional de Nanotecnología  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Costa Rica</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Instituto Tecnológico de Costa Rica  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Costa Rica</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Instituto Tecnológico de Costa Rica Centro de Investigación en Biotecnología ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Costa Rica</country>
</aff>
<aff id="Af6">
<institution><![CDATA[,Instituto Tecnológico de Costa Rica Escuela de Biología Centro de Investigación en Biotecnología]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Costa Rica</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>05</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>05</month>
<year>2015</year>
</pub-date>
<volume>28</volume>
<fpage>46</fpage>
<lpage>57</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_arttext&amp;pid=S0379-39822015000500046&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_abstract&amp;pid=S0379-39822015000500046&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_pdf&amp;pid=S0379-39822015000500046&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La reconstrucción de tejidos y órganos mediante ingeniería de tejidos ha permitido la elaboración y comercialización de diversos sustitutos o equivalentes epiteliales, que han sido utilizados desde hace más de 30 años a escala internacional para el tratamiento de lesiones en pacientes humanos. Estos injertos o implantes se confeccionan con materiales biodegradables (naturales o polímeros sintéticos) que sirven como matrices para la adhesión y proliferación celular y pueden contener células de diversos orígenes (autólogas, alogénicas o xenogénicas). Su principal ventaja clínica consiste en proporcionar una reepitelización efectiva en lesiones de gran extensión, lo que es particularmente relevante cuando hay poco tejido disponible para hacer autoinjertos. Además, ofrecen una cobertura al lecho de la lesión, evitando la deshidratación y las infecciones microbianas. Sin embargo, aún existen numerosos retos para asegurar la funcionalidad inmediata y la permanencia a largo plazo de los implantes, así como la reproducción exacta de la estructura y fisiología normal del tejido. En Costa Rica, el Centro de Investigación en Biotecnología del Instituto Tecnológico de Costa Rica cuenta con el único laboratorio en el país dedicado al cultivo in vitro de células de piel para la reconstrucción de equivalentes epiteliales con fines terapéuticos.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Tissue Engineering strategies for tissue and organ regeneration have allowed the fabrication and commercialization of diverse skin substitutes, which have been applied in different parts of the world on human patients over the course of the last 30 years. These grafts have been developed using biodegradable materials (of natural or synthetic origin) as scaffolds for the adhesion and proliferation of cells that may be of different origins (autologous, allogenic and xenogenic). The main clinical advantage of these materials is to provide an effective re-epitelization of large wounds, which is particularly relevant when there is little tissue available for autografts. Also, skin equivalents provide coverage for skin lesions, avoiding dehydration and microbial infections. Despite these advantages, there are still many challenges to solve including the immediate functionality and long term permanency of the grafts and the exact reproduction of the normal tissue structure and physiology. In Costa Rica, the only laboratory dedicated to in vitro skin cell culture for reconstructing epithelial equivalents with therapeutic applications is located at the Biotechnology Research Center at the Costa Rica Institute of Technology.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Piel]]></kwd>
<kwd lng="es"><![CDATA[cultivo celular]]></kwd>
<kwd lng="es"><![CDATA[ingeniería de tejidos]]></kwd>
<kwd lng="es"><![CDATA[trasplante]]></kwd>
<kwd lng="es"><![CDATA[injerto]]></kwd>
<kwd lng="es"><![CDATA[equivalentes epiteliales]]></kwd>
<kwd lng="en"><![CDATA[Skin]]></kwd>
<kwd lng="en"><![CDATA[cell culture]]></kwd>
<kwd lng="en"><![CDATA[Tissue Engineering]]></kwd>
<kwd lng="en"><![CDATA[transplant]]></kwd>
<kwd lng="en"><![CDATA[graft]]></kwd>
<kwd lng="en"><![CDATA[epithelial equivalents]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Arvelo]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
<name>
<surname><![CDATA[Pérez]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[Cotte]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Obtención de láminas de piel humana mediante ingeniería de tejidos.]]></article-title>
<source><![CDATA[ACV]]></source>
<year>2004</year>
<volume>55</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>74-82</page-range></nlm-citation>
</ref>
<ref id="B2">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Atiyeh]]></surname>
<given-names><![CDATA[B.]]></given-names>
</name>
<name>
<surname><![CDATA[Costagliola]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Cultured epithelial autograft (CEA) in burn treatment: Three decades later.]]></article-title>
<source><![CDATA[Burns]]></source>
<year>2007</year>
<volume>33</volume>
<page-range>405-13</page-range></nlm-citation>
</ref>
<ref id="B3">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Barret]]></surname>
<given-names><![CDATA[J. P.]]></given-names>
</name>
<name>
<surname><![CDATA[Wolf]]></surname>
<given-names><![CDATA[S. E.]]></given-names>
</name>
<name>
<surname><![CDATA[Desai]]></surname>
<given-names><![CDATA[M. H.]]></given-names>
</name>
<name>
<surname><![CDATA[Herndon]]></surname>
<given-names><![CDATA[D. N.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Cost-efficacy of cultured epidermal autografts in massive pediatric burns.]]></article-title>
<source><![CDATA[Ann. Surg.]]></source>
<year>2000</year>
<volume>231</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>869-76</page-range></nlm-citation>
</ref>
<ref id="B4">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Böttcher-Haberzeth]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Biedermann]]></surname>
<given-names><![CDATA[T.]]></given-names>
</name>
<name>
<surname><![CDATA[Reichmann]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Tissue engineering of skin.]]></article-title>
<source><![CDATA[Burns]]></source>
<year>2010</year>
<volume>36</volume>
<page-range>450-60</page-range></nlm-citation>
</ref>
<ref id="B5">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Boyce]]></surname>
<given-names><![CDATA[S. T.]]></given-names>
</name>
<name>
<surname><![CDATA[Warden]]></surname>
<given-names><![CDATA[G. D.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Principles and practices for treatment of cutaneous wounds with cultured skin substitutes.]]></article-title>
<source><![CDATA[The American Journal of Surgery]]></source>
<year>2002</year>
<volume>183</volume>
<page-range>445-56</page-range></nlm-citation>
</ref>
<ref id="B6">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Brychta]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Adler]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Rihovd]]></surname>
<given-names><![CDATA[V.]]></given-names>
</name>
<name>
<surname><![CDATA[Komdrkovd]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Cultured skin cells for treatment of burns.]]></article-title>
<source><![CDATA[Ann. Medit. Burns Club]]></source>
<year>1994</year>
<volume>71</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>206-8</page-range></nlm-citation>
</ref>
<ref id="B7">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Burnouf]]></surname>
<given-names><![CDATA[T.]]></given-names>
</name>
<name>
<surname><![CDATA[Radosevich]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Goubran]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
</person-group>
<source><![CDATA[Hemoderivados hemostáticos locales: sellador de fibrina y gel de plaquetas.]]></source>
<year>2004</year>
<publisher-loc><![CDATA[Québec ]]></publisher-loc>
<publisher-name><![CDATA[Federación Mundial de Hemofilia]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B8">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Carsin]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
<name>
<surname><![CDATA[Ainaud]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[Le Bever]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
<name>
<surname><![CDATA[Rives]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Lakhel]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Stephanazzi]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Lambert]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
<name>
<surname><![CDATA[Perrot]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Cultured epithelial autografts in extensive burn coverage of severely traumatized patients: A five year single-center experience with 30 patients.]]></article-title>
<source><![CDATA[Burns]]></source>
<year>2000</year>
<volume>26</volume>
<page-range>379-87</page-range></nlm-citation>
</ref>
<ref id="B9">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chen]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
<name>
<surname><![CDATA[Ushida]]></surname>
<given-names><![CDATA[T.]]></given-names>
</name>
<name>
<surname><![CDATA[Tateish]]></surname>
<given-names><![CDATA[T.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Scaffold design for Tissue Engineering.]]></article-title>
<source><![CDATA[Macromol. Biosci.]]></source>
<year>2002</year>
<volume>2</volume>
<page-range>67-77</page-range></nlm-citation>
</ref>
<ref id="B10">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chern]]></surname>
<given-names><![CDATA[P. L.]]></given-names>
</name>
<name>
<surname><![CDATA[Baum]]></surname>
<given-names><![CDATA[C. L.]]></given-names>
</name>
<name>
<surname><![CDATA[Arpey]]></surname>
<given-names><![CDATA[C. J.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Biologic Dressings: Current applications and limitations in dermatologic surgery.]]></article-title>
<source><![CDATA[Dermatol. Surg]]></source>
<year>2009</year>
<volume>35</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>891-906</page-range></nlm-citation>
</ref>
<ref id="B11">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Coto-Segura]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[García]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[García]]></surname>
<given-names><![CDATA[V.]]></given-names>
</name>
<name>
<surname><![CDATA[Fueyo-Casado]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Vázquez-López]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
<name>
<surname><![CDATA[Pérez-Oliva]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
<name>
<surname><![CDATA[Meana-Infiesta]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Efficacy of a self-made artificial skin in the treatment of chronic ulcers.]]></article-title>
<source><![CDATA[Dermatol. Surg]]></source>
<year>2007</year>
<volume>33</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>392-4</page-range></nlm-citation>
</ref>
<ref id="B12">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Estrada]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Paz]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[López]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Ingeniería de Tejido Óseo: Consideraciones básicas.]]></article-title>
<source><![CDATA[Revista EIA]]></source>
<year>2006</year>
<volume>1</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>93-100</page-range></nlm-citation>
</ref>
<ref id="B13">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Flasza]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Kemp]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[Shering]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[Qiao]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Marchall]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[Bokta]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Johnson]]></surname>
<given-names><![CDATA[P. A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Development and manufacture of an investigational human living dermal equivalent (ICX-SKN).]]></article-title>
<source><![CDATA[Regen. Med.]]></source>
<year>2007</year>
<volume>2</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>903-18</page-range></nlm-citation>
</ref>
<ref id="B14">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hernon]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Dawson]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Freedlander]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[Short]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Haddow]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[Brotherston]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[MacNeil]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Clinical experience using cultured epithelial autografts leads to an alternative methodology for transferring skin cells from the laboratory to the patient.]]></article-title>
<source><![CDATA[Regenerative Med.]]></source>
<year>2006</year>
<volume>1</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>809-21</page-range></nlm-citation>
</ref>
<ref id="B15">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hierner]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Degreef]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
<name>
<surname><![CDATA[Vranckx]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Garmyn]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Massage]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[van Brusse]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Skin grafting and wound healing - the dermato-plastic team approach.]]></article-title>
<source><![CDATA[Clin. Dermatol.]]></source>
<year>2005</year>
<volume>23</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>343-52</page-range></nlm-citation>
</ref>
<ref id="B16">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Horch]]></surname>
<given-names><![CDATA[R. E.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Tissue Engineering of Cultured Skin Substitutes.]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Meyer]]></surname>
<given-names><![CDATA[U.]]></given-names>
</name>
<name>
<surname><![CDATA[Meyer]]></surname>
<given-names><![CDATA[T.]]></given-names>
</name>
<name>
<surname><![CDATA[Handschel]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Wiesmann]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
</person-group>
<source><![CDATA[Fundamentals of Tissue Engineering and Regenerative Medicine.]]></source>
<year>2009</year>
<publisher-loc><![CDATA[Alemania ]]></publisher-loc>
<publisher-name><![CDATA[Springer-Verlag]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B17">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jiménez]]></surname>
<given-names><![CDATA[P. A.]]></given-names>
</name>
<name>
<surname><![CDATA[Jiménez]]></surname>
<given-names><![CDATA[S. E.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Tissue and cellular approaches to wound repair.]]></article-title>
<source><![CDATA[Am. J. Surg.]]></source>
<year>2004</year>
<volume>184</volume>
<numero>5A</numero>
<issue>5A</issue>
<page-range>56S64S</page-range></nlm-citation>
</ref>
<ref id="B18">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jones]]></surname>
<given-names><![CDATA[I.]]></given-names>
</name>
<name>
<surname><![CDATA[Lachlan]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Robin]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A guide to biological skin substitutes.]]></article-title>
<source><![CDATA[British Journal of Plastic Surgery]]></source>
<year>2002</year>
<volume>55</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>185-93</page-range></nlm-citation>
</ref>
<ref id="B19">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kamolz]]></surname>
<given-names><![CDATA[L. P.]]></given-names>
</name>
<name>
<surname><![CDATA[Lumenta]]></surname>
<given-names><![CDATA[D. B.]]></given-names>
</name>
<name>
<surname><![CDATA[Kitzinger]]></surname>
<given-names><![CDATA[H. B.]]></given-names>
</name>
<name>
<surname><![CDATA[Frey]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Tissue engineering for cutaneous wounds: an overview of current standards and possibilities.]]></article-title>
<source><![CDATA[Eur. Surg.]]></source>
<year>2008</year>
<volume>40</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>19-26</page-range></nlm-citation>
</ref>
<ref id="B20">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kwan]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Slater]]></surname>
<given-names><![CDATA[B.]]></given-names>
</name>
<name>
<surname><![CDATA[Chang]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[Longaker]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Gurtner]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Tissue Engineering Applications in Plastic Surgery.]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Meyer]]></surname>
<given-names><![CDATA[U.]]></given-names>
</name>
<name>
<surname><![CDATA[Meyer]]></surname>
<given-names><![CDATA[T.]]></given-names>
</name>
<name>
<surname><![CDATA[Handschel]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Wiesmann]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
</person-group>
<source><![CDATA[Fundamentals of Tissue Engineering and Regenerative.]]></source>
<year>2009</year>
<publisher-loc><![CDATA[Alemania ]]></publisher-loc>
<publisher-name><![CDATA[Springer-Verlag]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B21">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Loss]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Wedler]]></surname>
<given-names><![CDATA[V.]]></given-names>
</name>
<name>
<surname><![CDATA[Kunzi]]></surname>
<given-names><![CDATA[W.]]></given-names>
</name>
<name>
<surname><![CDATA[Meuli-simmen]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Meyer]]></surname>
<given-names><![CDATA[V. E.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Artificial skin, split-thickness autograft and cultured autologous keratinocytes combined to treat a severe burn injury of 93% of TBSA.]]></article-title>
<source><![CDATA[Burns]]></source>
<year>2000</year>
<volume>26</volume>
<page-range>644-52</page-range></nlm-citation>
</ref>
<ref id="B22">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[MacNeil]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Progress and opportunities for tissue-engineered skin.]]></article-title>
<source><![CDATA[Nature]]></source>
<year>2007</year>
<volume>445</volume>
<page-range>874-80</page-range></nlm-citation>
</ref>
<ref id="B23">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Nie]]></surname>
<given-names><![CDATA[X.]]></given-names>
</name>
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[J. Y.]]></given-names>
</name>
<name>
<surname><![CDATA[Cai]]></surname>
<given-names><![CDATA[K. J.]]></given-names>
</name>
<name>
<surname><![CDATA[Yang]]></surname>
<given-names><![CDATA[M. H.]]></given-names>
</name>
<name>
<surname><![CDATA[Xiao]]></surname>
<given-names><![CDATA[A. H.]]></given-names>
</name>
<name>
<surname><![CDATA[Hu]]></surname>
<given-names><![CDATA[H. D.]]></given-names>
</name>
<name>
<surname><![CDATA[Liu]]></surname>
<given-names><![CDATA[L. Y.]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[H. J.]]></given-names>
</name>
<name>
<surname><![CDATA[Ning]]></surname>
<given-names><![CDATA[W.]]></given-names>
</name>
<name>
<surname><![CDATA[Jin]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Cosmetic improvement in various acute skin defects treated with tissue-engineered skin.]]></article-title>
<source><![CDATA[Artificial Organs]]></source>
<year>2007</year>
<volume>31</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>703-10</page-range></nlm-citation>
</ref>
<ref id="B24">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Reinhart]]></surname>
<given-names><![CDATA[U.]]></given-names>
</name>
<name>
<surname><![CDATA[Stern-Straeter]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Riedel]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
<name>
<surname><![CDATA[Bran]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
<name>
<surname><![CDATA[Hörmann]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
<name>
<surname><![CDATA[Riedel]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Tissue engineering in head and neck reconstructive surgery: what type of tissue do we need?]]></article-title>
<source><![CDATA[Eur. Arch. Otorhinolaryngol.]]></source>
<year>2007</year>
<volume>264</volume>
<numero>11</numero>
<issue>11</issue>
<page-range>1343-56</page-range></nlm-citation>
</ref>
<ref id="B25">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rheinwald]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Green]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Formation of a keratinizing epithelium in culture by a cloned cell line derived from teratoma.]]></article-title>
<source><![CDATA[Cell]]></source>
<year>1975</year>
<volume>6</volume>
<page-range>317-30</page-range></nlm-citation>
</ref>
<ref id="B26">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sachlos]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[Czernuszka]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Making tissue engineering scaffolds work. Review on the application of solid freeform fabrication technology to the production of tissue engineering scaffolds.]]></article-title>
<source><![CDATA[European Cells and Materials]]></source>
<year>2003</year>
<volume>5</volume>
<page-range>29-40</page-range></nlm-citation>
</ref>
<ref id="B27">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[San Román]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Gallardo]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Vázquez]]></surname>
<given-names><![CDATA[B.]]></given-names>
</name>
<name>
<surname><![CDATA[López Bravo]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Ingeniería de tejidos: contribución de los polímeros al desarrollo de los procesos de regeneración tisular.]]></article-title>
<source><![CDATA[Anales de la Real Sociedad Española de Química]]></source>
<year>2000</year>
<volume>1</volume>
<page-range>5-18</page-range></nlm-citation>
</ref>
<ref id="B28">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Shores]]></surname>
<given-names><![CDATA[J. T.]]></given-names>
</name>
<name>
<surname><![CDATA[Gabriel]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Gupta]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Skin substitutes and alternatives: A Review.]]></article-title>
<source><![CDATA[Adv. Skin Wound Care]]></source>
<year>2007</year>
<volume>20</volume>
<page-range>493-508</page-range></nlm-citation>
</ref>
<ref id="B29">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wood]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
<name>
<surname><![CDATA[Kolybaba]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Allen]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The use of cultured epithelial autograft in the treatment of major burn injuries: A critical review of the literature.]]></article-title>
<source><![CDATA[Burns]]></source>
<year>2006</year>
<volume>32</volume>
<page-range>395-401</page-range></nlm-citation>
</ref>
<ref id="B30">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wysocki]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Dorsett-Martin]]></surname>
<given-names><![CDATA[W.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[New Advances in skin substitutes, dermal fillers and other products have expanded the surgical approaches that can be considered to cover tissue defects.]]></article-title>
<source><![CDATA[ORNurse]]></source>
<year>2008</year>
<volume>2</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>30-8</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
