<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0001-6002</journal-id>
<journal-title><![CDATA[Acta Médica Costarricense]]></journal-title>
<abbrev-journal-title><![CDATA[Acta méd. costarric]]></abbrev-journal-title>
<issn>0001-6002</issn>
<publisher>
<publisher-name><![CDATA[Colegio de Médicos y Cirujanos de Costa Rica]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0001-60022023000400181</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Futuro de la terapia y el diagnóstico con vesículas extracelulares]]></article-title>
<article-title xml:lang="en"><![CDATA[Future of therapeutics and diagnostics with extracellular vesicles]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Alvarado-Ocampo]]></surname>
<given-names><![CDATA[Johan]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Abrahams-Sandí]]></surname>
<given-names><![CDATA[Elizabeth]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Retana-Moreira]]></surname>
<given-names><![CDATA[Lissette]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Costa Rica Facultad de Microbiología Centro de Investigación en Enfermedades Tropicales]]></institution>
<addr-line><![CDATA[ San José]]></addr-line>
<country>Costa Rica</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Costa Rica Facultad de Microbiología Departamento de Parasitología]]></institution>
<addr-line><![CDATA[ San José]]></addr-line>
<country>Costa Rica</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad de Costa Rica Facultad de Microbiología, Departamento de Parasitología]]></institution>
<addr-line><![CDATA[ San José]]></addr-line>
<country>Costa Rica</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2023</year>
</pub-date>
<volume>65</volume>
<numero>4</numero>
<fpage>181</fpage>
<lpage>188</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_arttext&amp;pid=S0001-60022023000400181&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_abstract&amp;pid=S0001-60022023000400181&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_pdf&amp;pid=S0001-60022023000400181&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen Las vesículas extracelulares son nanoparticulas secretadas por células procariotas y eucariotas, con funciones variadas que van desde la comunicación intercelular hasta la modulación de la respuesta inmune. La investigación en este tema se enfocó inicialmente en el aislamiento, identificación y caracterización, para luego abarcar los mecanismos fisiológicos en los que se ven involucradas. Más recientemente, la investigación, particularmente centrada en exosomas, ha permitido abrir campo a novedosas hipótesis sobre su utilidad en inmunoterapia y como marcadores biológicos. Esta revisión explora aspectos básicos sobre la biogénesis y la composición de los exosomas, así como su uso en diagnóstico y tratamiento, a partir del conocimiento generado sobre su aislamiento y purificación, distribución de cargos específicos y su relación con la respuesta inmune. Los hallazgos sobre su aplicabilidad en procesos cancerosos son promisorios; sin embargo, existe toda una ventana de posibilidades para investigar esta plataforma molecular como potenciales vacunas acelulares y marcadores de pronóstico, diagnóstico y alerta, tanto en cáncer como en patologías causadas por agentes infecciosos.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Extracellular vesicles are nanoparticles released by prokaryotic and eukaryotic cells, with a variety of functional roles in intercellular communication and even in modulation of the immune response. Research in this topic was initially focused on isolation, identification and characterization of the vesicles, with subsequent understanding of the physiological mechanisms in which they are involved. Furthermore, recent studies, particularly with exosomes, have opened the field to novel hypotheses about their usefulness in immunotherapy and as biological markers. This review explores general aspects about the biogenesis and composition of exosomes, as well as their potential use in diagnosis and treatment, based on the knowledge generated about their isolation, production, cargoes, delivery engineering and relationship with the immune response. The findings on its applicability in cancerous processes are promising, but there is still a variety of investigation possibilities of this molecular platforms as cell-free vaccines and as prognostic, diagnostic and/or warning markers, both in cancer but also in infectious diseases.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[vesículas extracelulares]]></kwd>
<kwd lng="es"><![CDATA[exovesículas]]></kwd>
<kwd lng="es"><![CDATA[inmunoterapia]]></kwd>
<kwd lng="es"><![CDATA[vacunas]]></kwd>
<kwd lng="es"><![CDATA[biomarcadores.]]></kwd>
<kwd lng="en"><![CDATA[extracellular vesicles]]></kwd>
<kwd lng="en"><![CDATA[exovesicles]]></kwd>
<kwd lng="en"><![CDATA[immunotherapy]]></kwd>
<kwd lng="en"><![CDATA[vaccines]]></kwd>
<kwd lng="en"><![CDATA[biomarkers.]]></kwd>
</kwd-group>
</article-meta>
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