<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1659-4266</journal-id>
<journal-title><![CDATA[Cuadernos de Investigación UNED]]></journal-title>
<abbrev-journal-title><![CDATA[Cuadernos de Investigación UNED]]></abbrev-journal-title>
<issn>1659-4266</issn>
<publisher>
<publisher-name><![CDATA[Universidad Estatal a Distancia de Costa Rica]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1659-42662018000100102</article-id>
<article-id pub-id-type="doi">10.22458/urj.v10i1.2008</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Genotoxicity and histopathological assessment of silver nanoparticles in Swiss albino mice]]></article-title>
<article-title xml:lang="es"><![CDATA[Genotoxicidad y evaluación histopatológica de nanopartículas de plata en ratones albinos suizos]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Iyiola]]></surname>
<given-names><![CDATA[Oluyinka. A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Olafimihan]]></surname>
<given-names><![CDATA[Temitope F.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sulaiman]]></surname>
<given-names><![CDATA[Faoziyat A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Anifowoshe]]></surname>
<given-names><![CDATA[Abass T.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,University of Ilorin Cell Biology and Genetics Unit Department of Zoology]]></institution>
<addr-line><![CDATA[Ilorin Kwara State]]></addr-line>
<country>Nigeria</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,University of Ilorin Ecology and Environmental Biology Unit Department of Zoology]]></institution>
<addr-line><![CDATA[Ilorin Kwara State]]></addr-line>
<country>Nigeria</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,University of Ilorin Department of Biochemistry ]]></institution>
<addr-line><![CDATA[Ilorin Kwara State]]></addr-line>
<country>Nigeria</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2018</year>
</pub-date>
<volume>10</volume>
<numero>1</numero>
<fpage>102</fpage>
<lpage>109</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_arttext&amp;pid=S1659-42662018000100102&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_abstract&amp;pid=S1659-42662018000100102&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_pdf&amp;pid=S1659-42662018000100102&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Silver nanoparticles (AgNPs) are widely used in industrial and medical applications. However, there is a growing concern about the potentialities of AgNPs to induce genotoxicity and DNA damage in humans. In this study, genotoxic and histopathological effects of AgNPs were investigated in mice using two well-characterized genetic assays: mouse bone marrow micronuclei (MN) and mouse sperm morphology assays. Swiss albino mice (total N=18) were exposed to varying concentrations (3,000mg/Kg, 4,000mg/Kg, 5,000mg/Kg and 6,000mg/Kg) of AgNPs for 5 consecutive days and observed for 30 days afterwards. Distilled water and colchicine were used as negative and positive controls, respectively. The MN assay showed that the frequency of micronuclei induction increased with AgNP concentration. Statistically significant differences (p&lt;0,05) were observed for the micronucleus frequency in the blood erythrocytes in all the test concentrations. Sperm head morphology assay also revealed various types of abnormal sperm head morphology and there was statistically significant increase in frequency of sperm abnormalities. Histopathological profiles of the liver also showed enlarge sinusoids, irregular portal tract, and dose-dependent vacuolation. These results suggest that AgNPs is genotoxic and represent a serious health risk to human heatlh.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen Las nanopartículas de plata (AgNPs) son ampliamente utilizadas en la industria y la medicina. Sin embargo, existe una creciente preocupación acerca de las potencialidades de los AgNPs para inducir genotoxicidad y daño del ADN en seres humanos. En este estudio, se investigaron los efectos genotóxicos e histopatológicos de los AgNPs en ratones utilizando dos ensayos genéticos: micronúcleos de médula ósea de ratón (MN) y ensayos de morfología de espermatozoides de ratón. Un total de 16 ratones de peso medio de 25-30g se expusieron a concentraciones variables (3,000mg/Kg, 4,000mg/Kg, 5,000mg/Kg y 6,000mg/Kg) de AgNP durante 5 días consecutivos y se observaron durante 30 días. Usé agua destilada y colchicina como controles negativos y positivos, respectivamente. El ensayo MN mostró que la frecuencia de inducción de micronúcleos aumentó con lasconcentraciones de AgNPs. En todas las concentraciones de ensayo hubo diferencias estadísticamente significativas (p&lt;0,05) en la frecuencia micronuclear de eritrocitos sanguíneos. Hubo varios tipos de morfología anormal de la cabeza del espermatozoo y aumento estadísticamente significativo en la frecuencia de anormalidades espermáticas. Los perfiles histopatológicos del hígado también mostraron sinusoides de aumento, tracto portal irregular y aparición de vacuolación dependiente de la dosis. Estos resultados sugieren que los AgNPs son genotóxicos y plantean un serio riesgo para la salud de los seres humanos considerando su uso en dispositivos médicos, hogar y varios tipos de productos de consumo.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[silver nanoparticles]]></kwd>
<kwd lng="en"><![CDATA[histopathological]]></kwd>
<kwd lng="en"><![CDATA[sperm morphology]]></kwd>
<kwd lng="en"><![CDATA[genotoxicity]]></kwd>
<kwd lng="en"><![CDATA[micronucleus]]></kwd>
<kwd lng="es"><![CDATA[nanopartículas de plata]]></kwd>
<kwd lng="es"><![CDATA[histopatológico]]></kwd>
<kwd lng="es"><![CDATA[morfología espermática]]></kwd>
<kwd lng="es"><![CDATA[genotoxicidad]]></kwd>
<kwd lng="es"><![CDATA[micronúcleo]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Abdelhalim]]></surname>
<given-names><![CDATA[M. A. K.]]></given-names>
</name>
<name>
<surname><![CDATA[Jarrar]]></surname>
<given-names><![CDATA[B. M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Gold nanoparticles administration induced prominent inflammatory, central vein intima disruption, fatty change and Kupffer cells hyperplasia]]></article-title>
<source><![CDATA[Lipids in Health and Disease]]></source>
<year>2011</year>
<volume>10</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>133</page-range></nlm-citation>
</ref>
<ref id="B2">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ahamed]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Silver nanoparticles induced heat shock protein, oxidative str essapoptosis in Drosophila melanogaster]]></article-title>
<source><![CDATA[Toxicology and Applied Pharmacology]]></source>
<year>2010</year>
<volume>242</volume>
<page-range>263-9</page-range></nlm-citation>
</ref>
<ref id="B3">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Alizadeh]]></surname>
<given-names><![CDATA[Z.]]></given-names>
</name>
<name>
<surname><![CDATA[Mahmoudian]]></surname>
<given-names><![CDATA[Z. G.]]></given-names>
</name>
<name>
<surname><![CDATA[Sohrabi]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Lahoutian]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
<name>
<surname><![CDATA[Assari]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Alizadeh]]></surname>
<given-names><![CDATA[Z]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Histological alterations and apoptosis in rat liver following silver nanoparticle intraorally administration]]></article-title>
<source><![CDATA[Entomology and Applied Science Letters]]></source>
<year>2016</year>
<volume>3</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>27-35</page-range></nlm-citation>
</ref>
<ref id="B4">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Amin]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
<name>
<surname><![CDATA[Hawas]]></surname>
<given-names><![CDATA[A. M.]]></given-names>
</name>
<name>
<surname><![CDATA[El-Batal]]></surname>
<given-names><![CDATA[A. I.]]></given-names>
</name>
<name>
<surname><![CDATA[Seham]]></surname>
<given-names><![CDATA[H. M.]]></given-names>
</name>
<name>
<surname><![CDATA[Mostafa]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Evaluation of Acute and Subchronic Toxicity of Silver Nanoparticles in Normal and Irradiated Animals]]></article-title>
<source><![CDATA[British Journal of Pharmacology and Toxicology]]></source>
<year>2015</year>
<volume>6</volume>
<page-range>22-38</page-range></nlm-citation>
</ref>
<ref id="B5">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Asharani]]></surname>
<given-names><![CDATA[P. V.]]></given-names>
</name>
<name>
<surname><![CDATA[Wu]]></surname>
<given-names><![CDATA[Y. L.]]></given-names>
</name>
<name>
<surname><![CDATA[Gong]]></surname>
<given-names><![CDATA[Z.]]></given-names>
</name>
<name>
<surname><![CDATA[Valiyaveetti]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Toxicity of silver nanoparticles in zebrafish models]]></article-title>
<source><![CDATA[Nanotechnology]]></source>
<year>2008</year>
<volume>19</volume>
<numero>25</numero>
<issue>25</issue>
<page-range>55-102</page-range></nlm-citation>
</ref>
<ref id="B6">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bakare]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Okunola]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Adetunji]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Hafeez]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Genotoxicity assessment of a pharmaceutical effluent using four bioassays]]></article-title>
<source><![CDATA[Genetics and Molecular Biology]]></source>
<year>2009</year>
<volume>32</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>373-81</page-range></nlm-citation>
</ref>
<ref id="B7">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bar-Ilan]]></surname>
<given-names><![CDATA[O.]]></given-names>
</name>
<name>
<surname><![CDATA[Albrecht]]></surname>
<given-names><![CDATA[R. M.]]></given-names>
</name>
<name>
<surname><![CDATA[Fako]]></surname>
<given-names><![CDATA[V. E.]]></given-names>
</name>
<name>
<surname><![CDATA[Furgeson]]></surname>
<given-names><![CDATA[D. Y]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Toxicity assessments of multisized gold and silver nanoparticles in Zebrafish embryos]]></article-title>
<source><![CDATA[Small]]></source>
<year>2009</year>
<volume>5</volume>
<numero>16</numero>
<issue>16</issue>
<page-range>1897-910</page-range></nlm-citation>
</ref>
<ref id="B8">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bilberg]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
<name>
<surname><![CDATA[Doving]]></surname>
<given-names><![CDATA[K. B.]]></given-names>
</name>
<name>
<surname><![CDATA[Beedholm]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
<name>
<surname><![CDATA[Baatrup]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Silver nanoparticles disrupt olfaction in Crucian carp (Carassius carassius) and Eurasian perch (Perca fluviatilis)]]></article-title>
<source><![CDATA[Aquatic Toxicology]]></source>
<year>2011</year>
<volume>104</volume>
<page-range>145-52</page-range></nlm-citation>
</ref>
<ref id="B9">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Braydich-Stolle]]></surname>
<given-names><![CDATA[L. K.]]></given-names>
</name>
<name>
<surname><![CDATA[Lucas]]></surname>
<given-names><![CDATA[B.]]></given-names>
</name>
<name>
<surname><![CDATA[Schrand]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Murdock]]></surname>
<given-names><![CDATA[R. C.]]></given-names>
</name>
<name>
<surname><![CDATA[Lee]]></surname>
<given-names><![CDATA[T.]]></given-names>
</name>
<name>
<surname><![CDATA[Schlager]]></surname>
<given-names><![CDATA[J. J.]]></given-names>
</name>
<name>
<surname><![CDATA[Hofmann]]></surname>
<given-names><![CDATA[M. C.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Silver nanoparticles disrupt GDNF/Fyn kinase signaling in spermatogonial stem cells]]></article-title>
<source><![CDATA[Toxicological Sciences]]></source>
<year>2010</year>
<volume>116</volume>
<page-range>577-89</page-range></nlm-citation>
</ref>
<ref id="B10">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Braydich-Stolle]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[Hussain]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Schlager]]></surname>
<given-names><![CDATA[J. J.]]></given-names>
</name>
<name>
<surname><![CDATA[Hofmann]]></surname>
<given-names><![CDATA[M. C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[In vitro cytotoxicity of nanoparticles in mammalian germline stem cells]]></article-title>
<source><![CDATA[Toxicological Sciences]]></source>
<year>2005</year>
<volume>88</volume>
<page-range>412-9</page-range></nlm-citation>
</ref>
<ref id="B11">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cheraghi]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Hosseini]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[Hoshmandfar]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Sahraei]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Hematologic parameters study of male and female rats administrated with different concentrations of silver nanoparticles]]></article-title>
<source><![CDATA[International Journal of Agriculture and Crop Sciences]]></source>
<year>2013</year>
<volume>5</volume>
<page-range>789-96</page-range></nlm-citation>
</ref>
<ref id="B12">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Contado]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Nanomaterials in consumer products: a challenging analytical problem]]></article-title>
<source><![CDATA[Frontiers in Chemistry]]></source>
<year>2015</year>
<volume>3</volume>
<page-range>48</page-range></nlm-citation>
</ref>
<ref id="B13">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Demir]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[Kaya.]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
<name>
<surname><![CDATA[Kaya]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Genotoxic effects of zinc oxide and titanium dioxide nanoparticles on root meristem cells of Allium cepa by comet assay]]></article-title>
<source><![CDATA[Turkish Journal of Biology]]></source>
<year>2014</year>
<volume>38</volume>
<page-range>31-9</page-range></nlm-citation>
</ref>
<ref id="B14">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Echegoyen]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
<name>
<surname><![CDATA[Nerin]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Nanoparticle release fromnano-silver antimicrobial food containers]]></article-title>
<source><![CDATA[Food and Chemical Toxicology]]></source>
<year>2013</year>
<volume>62</volume>
<page-range>16-22</page-range></nlm-citation>
</ref>
<ref id="B15">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Foldbjerg]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Autrup]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Mechanisms of Silver Nanoparticle Toxicity]]></article-title>
<source><![CDATA[Archives of Basic and Applied Medicine]]></source>
<year>2013</year>
<volume>1</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>5-15</page-range></nlm-citation>
</ref>
<ref id="B16">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gaiser]]></surname>
<given-names><![CDATA[B.]]></given-names>
</name>
<name>
<surname><![CDATA[Hirn]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Kermanizadeh]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Kanase]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
<name>
<surname><![CDATA[Fytianos]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
<name>
<surname><![CDATA[Wenk]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Haberl]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
<name>
<surname><![CDATA[Brunelli]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Kreyling]]></surname>
<given-names><![CDATA[W. G.]]></given-names>
</name>
<name>
<surname><![CDATA[Stone]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Effects of Silver Nanoparticles on the Liver and Hepatocytes In Vitro]]></article-title>
<source><![CDATA[Toxicological Sciences]]></source>
<year>2013</year>
<volume>131</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>537-47</page-range></nlm-citation>
</ref>
<ref id="B17">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ghosh]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Manivannan]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Sinha]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Chakraborty]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Mallickd]]></surname>
<given-names><![CDATA[S. K.]]></given-names>
</name>
<name>
<surname><![CDATA[Bandyopadhyay]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Mukherjee]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[In vitro and in vivo genotoxicity of silver nanoparticles]]></article-title>
<source><![CDATA[Mutation Research]]></source>
<year>2012</year>
<volume>749</volume>
<page-range>60-9</page-range></nlm-citation>
</ref>
<ref id="B18">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Grosse]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Evje]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[Syversen]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Silver nanoparticle-induced cytotoxicity in rat brain endothelial cell culture]]></article-title>
<source><![CDATA[Toxicology in Vitro]]></source>
<year>2013</year>
<volume>27</volume>
<page-range>305-13</page-range></nlm-citation>
</ref>
<ref id="B19">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Heim]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Felder]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[Tahir]]></surname>
<given-names><![CDATA[N.M.]]></given-names>
</name>
<name>
<surname><![CDATA[Kaltbeitzel]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Heinricha]]></surname>
<given-names><![CDATA[U.R.]]></given-names>
</name>
<name>
<surname><![CDATA[Brochhausen]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Mailänder]]></surname>
<given-names><![CDATA[V.]]></given-names>
</name>
<name>
<surname><![CDATA[Tremel]]></surname>
<given-names><![CDATA[W.]]></given-names>
</name>
<name>
<surname><![CDATA[Brieger]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Genotoxic effects of Zinc oxide nanoparticles]]></article-title>
<source><![CDATA[Nanoscale]]></source>
<year>2015</year>
<volume>7</volume>
<page-range>8931-8</page-range></nlm-citation>
</ref>
<ref id="B20">
<nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Imani]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Halimi]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Khara]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<source><![CDATA[Effects of silver nanoparticles (AgNPs)]]></source>
<year>2015</year>
</nlm-citation>
</ref>
<ref id="B21">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kalishwaralal]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
<name>
<surname><![CDATA[Barathmanikanth]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Pandian]]></surname>
<given-names><![CDATA[S. R.]]></given-names>
</name>
<name>
<surname><![CDATA[Deepak]]></surname>
<given-names><![CDATA[V.]]></given-names>
</name>
<name>
<surname><![CDATA[Gurunathan]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Silver nanoparticle, a trove for retinal therapies]]></article-title>
<source><![CDATA[Journal of Controlled Release]]></source>
<year>2010</year>
<volume>145</volume>
<page-range>76-90</page-range></nlm-citation>
</ref>
<ref id="B22">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kim]]></surname>
<given-names><![CDATA[H. R.]]></given-names>
</name>
<name>
<surname><![CDATA[Kim]]></surname>
<given-names><![CDATA[M. J.]]></given-names>
</name>
<name>
<surname><![CDATA[Lee]]></surname>
<given-names><![CDATA[S. Y.]]></given-names>
</name>
<name>
<surname><![CDATA[Oh]]></surname>
<given-names><![CDATA[S. M.]]></given-names>
</name>
<name>
<surname><![CDATA[Chung]]></surname>
<given-names><![CDATA[K. H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Genotoxic effects of silver nanoparticles stimulated by oxidative stress in human normal bronchial epithelial (BEAS-2B) cells]]></article-title>
<source><![CDATA[Mutation Research]]></source>
<year>2011</year>
<volume>726</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>129-35</page-range></nlm-citation>
</ref>
<ref id="B23">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kim]]></surname>
<given-names><![CDATA[Y. S.]]></given-names>
</name>
<name>
<surname><![CDATA[Kim]]></surname>
<given-names><![CDATA[J. S.]]></given-names>
</name>
<name>
<surname><![CDATA[Cho]]></surname>
<given-names><![CDATA[H. S.]]></given-names>
</name>
<name>
<surname><![CDATA[Rha]]></surname>
<given-names><![CDATA[D. S.]]></given-names>
</name>
<name>
<surname><![CDATA[Kim]]></surname>
<given-names><![CDATA[J. M.]]></given-names>
</name>
<name>
<surname><![CDATA[Park]]></surname>
<given-names><![CDATA[J. D.]]></given-names>
</name>
<name>
<surname><![CDATA[Choi]]></surname>
<given-names><![CDATA[B. S.]]></given-names>
</name>
<name>
<surname><![CDATA[Lim]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Chang]]></surname>
<given-names><![CDATA[H. K.]]></given-names>
</name>
<name>
<surname><![CDATA[Chung]]></surname>
<given-names><![CDATA[Y. H.]]></given-names>
</name>
<name>
<surname><![CDATA[Kwon]]></surname>
<given-names><![CDATA[I. H.]]></given-names>
</name>
<name>
<surname><![CDATA[Jeong]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Han]]></surname>
<given-names><![CDATA[B. S.]]></given-names>
</name>
<name>
<surname><![CDATA[Yu]]></surname>
<given-names><![CDATA[I. J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Twenty-eight-day oral toxicity, genotoxicity and gender-related tissue distribution of silver nanoparticles in Sprague Dawley rats]]></article-title>
<source><![CDATA[Inhalation Toxicology]]></source>
<year>2008</year>
<volume>20</volume>
<page-range>575-83</page-range></nlm-citation>
</ref>
<ref id="B24">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kruszewski]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Brzoska]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
<name>
<surname><![CDATA[Brunborg]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
<name>
<surname><![CDATA[Asare]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
<name>
<surname><![CDATA[Dobrzynska]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Duzinska]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Fjellsbo]]></surname>
<given-names><![CDATA[L. M.]]></given-names>
</name>
<name>
<surname><![CDATA[Georgantzopoulou]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Gromadzka-Ostrowska]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Gutleb]]></surname>
<given-names><![CDATA[A. C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Toxicity of Silver Nanomaterials in Higher Eukaryotes]]></article-title>
<source><![CDATA[Advances in Molecular Toxicology]]></source>
<year>2011</year>
<volume>5</volume>
<page-range>179-259</page-range></nlm-citation>
</ref>
<ref id="B25">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mangelsdorf]]></surname>
<given-names><![CDATA[I.]]></given-names>
</name>
<name>
<surname><![CDATA[Buschmann]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Orthen]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Some aspects relating to the evaluation of the effects of chemicals on male fertility]]></article-title>
<source><![CDATA[Regulatory Toxicology and Pharmacology]]></source>
<year>2003</year>
<volume>37</volume>
<page-range>356-69</page-range></nlm-citation>
</ref>
<ref id="B26">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Miresmaeili]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Halvaei]]></surname>
<given-names><![CDATA[I.]]></given-names>
</name>
<name>
<surname><![CDATA[Fesahat]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
<name>
<surname><![CDATA[Fallah]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Nikonahad]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
<name>
<surname><![CDATA[Taherinejad]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[evaluating the role of silver nanoparticles on acrosomal reaction and spermatogenic cells in rat]]></article-title>
<source><![CDATA[Iranian Journal of Reproductive Medicine]]></source>
<year>2013</year>
<volume>11</volume>
<page-range>423-30</page-range></nlm-citation>
</ref>
<ref id="B27">
<nlm-citation citation-type="book">
<collab>National Research Council</collab>
<source><![CDATA[Guide for the Care and Use of Laboratory Animals]]></source>
<year>2011</year>
<edition>8th Ed</edition>
<page-range>491-5</page-range><publisher-loc><![CDATA[Washington, DC. ]]></publisher-loc>
<publisher-name><![CDATA[National Academies Science on hematological parameters of rainbow trout, Oncorhynchus mykiss]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B28">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Park]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[Bae]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[Yi]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Kim]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
<name>
<surname><![CDATA[Choi]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
<name>
<surname><![CDATA[Hee]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Yoon]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Lee]]></surname>
<given-names><![CDATA[B.]]></given-names>
</name>
<name>
<surname><![CDATA[Park]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Repeated-dose toxicity and inflammatory responses in mice by oral administration of silver nanoparticles]]></article-title>
<source><![CDATA[Environmental Toxicology and Pharmacology]]></source>
<year>2010</year>
<volume>30</volume>
<page-range>162-8</page-range></nlm-citation>
</ref>
<ref id="B29">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Saacke]]></surname>
<given-names><![CDATA[R. G]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[What is BSE-SFT standards: the relative importance of sperm morphology: an opinion]]></article-title>
<source><![CDATA[Proceedings Society Theriogenology]]></source>
<year>2001</year>
<volume>113</volume>
<page-range>81-7</page-range></nlm-citation>
</ref>
<ref id="B30">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Takeda]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
<name>
<surname><![CDATA[Suzuki]]></surname>
<given-names><![CDATA[K. I.]]></given-names>
</name>
<name>
<surname><![CDATA[Ishihara]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Kubo-Irie]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Fujimoto]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Tabata]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Sugamata]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Nanoparticles transferred from pregnant mice to their offspring can damage the genital and cranial nerve systems]]></article-title>
<source><![CDATA[Journal of Health Science]]></source>
<year>2009</year>
<volume>55</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>95-102</page-range></nlm-citation>
</ref>
<ref id="B31">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Taylor]]></surname>
<given-names><![CDATA[U.]]></given-names>
</name>
<name>
<surname><![CDATA[Barchanski]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Garrels]]></surname>
<given-names><![CDATA[W.]]></given-names>
</name>
<name>
<surname><![CDATA[Klein]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Kues]]></surname>
<given-names><![CDATA[W.]]></given-names>
</name>
<name>
<surname><![CDATA[Barcikowski]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Rath]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Toxicity of gold nanoparticles on somatic and reproductive cells]]></article-title>
<source><![CDATA[Nano-biotechnology for biomedical and diagnostic Research]]></source>
<year>2012</year>
<page-range>125-33</page-range><publisher-name><![CDATA[Springer Netherlands]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B32">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wijnhoven]]></surname>
<given-names><![CDATA[S. W.]]></given-names>
</name>
<name>
<surname><![CDATA[Peijnenburg]]></surname>
<given-names><![CDATA[W. J.]]></given-names>
</name>
<name>
<surname><![CDATA[Herberts]]></surname>
<given-names><![CDATA[C. A.]]></given-names>
</name>
<name>
<surname><![CDATA[Hagens]]></surname>
<given-names><![CDATA[W. I.]]></given-names>
</name>
<name>
<surname><![CDATA[Oomen]]></surname>
<given-names><![CDATA[A. G.]]></given-names>
</name>
<name>
<surname><![CDATA[Heugens]]></surname>
<given-names><![CDATA[E. H.]]></given-names>
</name>
<name>
<surname><![CDATA[Dekkers]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Nano-silver-a review of available data and knowledge gaps in human and environmental risk assessment]]></article-title>
<source><![CDATA[Nanotoxicology]]></source>
<year>2009</year>
<volume>3</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>109-38</page-range></nlm-citation>
</ref>
<ref id="B33">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wyrobek]]></surname>
<given-names><![CDATA[A. J.]]></given-names>
</name>
<name>
<surname><![CDATA[Bruce]]></surname>
<given-names><![CDATA[W. R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Chemical induction of sperm abnormalities in mice]]></article-title>
<source><![CDATA[Proceedings of the National Academy of Sciences]]></source>
<year>1975</year>
<volume>72</volume>
<numero>11</numero>
<issue>11</issue>
<page-range>4425-9</page-range></nlm-citation>
</ref>
<ref id="B34">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wyrobek]]></surname>
<given-names><![CDATA[A. J.]]></given-names>
</name>
<name>
<surname><![CDATA[Gordon]]></surname>
<given-names><![CDATA[L. A.]]></given-names>
</name>
<name>
<surname><![CDATA[Burkhart]]></surname>
<given-names><![CDATA[J. G.]]></given-names>
</name>
<name>
<surname><![CDATA[Francis]]></surname>
<given-names><![CDATA[M. W.]]></given-names>
</name>
<name>
<surname><![CDATA[Kapp]]></surname>
<given-names><![CDATA[R. W.]]></given-names>
</name>
<name>
<surname><![CDATA[Letz]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
<name>
<surname><![CDATA[Whorton]]></surname>
<given-names><![CDATA[M. D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[An evaluation of the mouse sperm morphology test and other sperm tests in nonhuman mammals: A report of the US Environmental Protection Agency Gene-Tox Program]]></article-title>
<source><![CDATA[Mutation Research /Reviews in Genetic Toxicology]]></source>
<year>1983</year>
<volume>115</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>1-72</page-range></nlm-citation>
</ref>
<ref id="B35">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Yavasoglua]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Ali Karaaslan]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[UyaniKgila]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
<name>
<surname><![CDATA[Sayim]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
<name>
<surname><![CDATA[Atesa]]></surname>
<given-names><![CDATA[U.]]></given-names>
</name>
<name>
<surname><![CDATA[Yavasoglub]]></surname>
<given-names><![CDATA[N. U. K]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Toxic effects of anatoxin-a on testes and sperm counts of male mice]]></article-title>
<source><![CDATA[Experimental and Toxicologic Pathology]]></source>
<year>2008</year>
<volume>60</volume>
<page-range>391-6</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
