<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1659-1321</journal-id>
<journal-title><![CDATA[Agronomía Mesoamericana]]></journal-title>
<abbrev-journal-title><![CDATA[Agron. Mesoam]]></abbrev-journal-title>
<issn>1659-1321</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Costa Rica]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1659-13212025000100019</article-id>
<article-id pub-id-type="doi">10.15517/am.2025.62055</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Estrategias de modelado para determinar la dosis efectiva de herbicidas]]></article-title>
<article-title xml:lang="en"><![CDATA[Modeling strategies to determine the effective dose of herbicides]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vargas Martínez]]></surname>
<given-names><![CDATA[Alejandro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vargas-Rojas]]></surname>
<given-names><![CDATA[Jorge Claudio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Corrales Brenes]]></surname>
<given-names><![CDATA[Eduardo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional  ]]></institution>
<addr-line><![CDATA[ Heredia]]></addr-line>
<country>Costa Rica</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Costa Rica Sede Regional de Guanacaste ]]></institution>
<addr-line><![CDATA[ Liberia]]></addr-line>
<country>Costa Rica</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Centro Agronómico Tropical de Investigación y Enseñanza (CATIE)  ]]></institution>
<addr-line><![CDATA[ Turrialba]]></addr-line>
<country>Costa Rica</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2025</year>
</pub-date>
<volume>36</volume>
<numero>1</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_arttext&amp;pid=S1659-13212025000100019&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_abstract&amp;pid=S1659-13212025000100019&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_pdf&amp;pid=S1659-13212025000100019&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción.  Los ensayos de dosis-respuesta se utilizan con el objetivo de seleccionar la dosis eficiente de herbicidas en el manejo de arvenses. El análisis de datos en estos experimentos ha recibido críticas debido al uso de modelos estadísticos que no se ajustan a la distribución de la variable respuesta, la omisión de la estructura original del diseño experimental y la preferencia por modelos parciales en lugar de ajustar un modelo único. Los modelos no lineales mixtos se presentan como una alternativa más precisa para analizar estos experimentos. Objetivo. Determinar la dosis efectiva de un herbicida mediante tres estrategias de modelación en ensayos de dosis-respuesta. Materiales y métodos. Se efectuaron dos experimentos independientes en invernaderos localizados en Tambor de Alajuela, Costa Rica, durante el 2012, en los que se cuantificó el peso fresco en gramos (g) de un biotipo de Paspalum paniculatum L. en función de los gramos de equivalente ácido (GEA) de un herbicida, bajo un diseño en bloques completos al azar. Se utilizó como base un modelo de regresión logística de cuatro parámetros, y se ajustaron tres variantes del modelo. Mediante los criterios de información penalizada (criterio de información de Akaike (AIC) y criterio de información bayesiano (BIC)), se seleccionó el modelo con mejor ajuste y menor incertidumbre. Resultados. La estrategia que consideró el experimento y el bloque dentro de cada experimento como efectos aleatorios resultó ser la más precisa. Este modelo estimó el intervalo de confianza (95 %) para la dosis efectiva media de GEA entre 335,12 y 384,32 g. Conclusiones. Integrar la información de experimentos independientes como efectos aleatorios en un único modelo generó estimaciones más precisas de la dosis efectiva de glifosato.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction.  Dose-response trials are used with the objective of selecting the efficient herbicide dose in weed management. Data analysis of these experiments has been criticized for the use of statistical models that do not fit the distribution of the response variable, failure to specify the original structure of the experimental design, and the preference for partial models instead of fitting a unique model. Nonlinear mixed models are presented as a more accurate alternative for analyzing these experiments. Objective. To determine the effective herbicide dose using three modeling strategies in dose-response trials. Materials and methods. Two independent experiments were conducted in greenhouses located in Tambor, Alajuela, Costa Rica, during 2012, where the fresh weight in grams (g) of a biotype of Paspalum paniculatum L. was quantified as a function of grams of acid equivalent (GAE) of an applied herbicide, under a randomized complete block design. A four-parameter logistic regression model was used as a basis, and three model variants were fitted. Using penalized information criteria (Akaike information criterion (AIC) and Bayesian information criterion (BIC)), the best-fitting model was chosen. Results. The strategy that considered the experiment and the block within each experiment as random effects proved to be the most accurate. This model estimated the confidence interval (95 %) for the mean effective dose of GAE between 335.12 and 384.32 g. Conclusions. Integrating information from independent experiments as random effects within a unique model generated more accurate estimates of glyphosate&#8217;s effective dose.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[regresión logística]]></kwd>
<kwd lng="es"><![CDATA[dosis-respuesta]]></kwd>
<kwd lng="es"><![CDATA[análisis estadístico]]></kwd>
<kwd lng="en"><![CDATA[logistic regression]]></kwd>
<kwd lng="en"><![CDATA[dose-response]]></kwd>
<kwd lng="en"><![CDATA[statistical analysis]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Burgos]]></surname>
<given-names><![CDATA[N. R.]]></given-names>
</name>
<name>
<surname><![CDATA[Tranel]]></surname>
<given-names><![CDATA[P. J.]]></given-names>
</name>
<name>
<surname><![CDATA[Streibig]]></surname>
<given-names><![CDATA[J. C.]]></given-names>
</name>
<name>
<surname><![CDATA[Davis]]></surname>
<given-names><![CDATA[V. M.]]></given-names>
</name>
<name>
<surname><![CDATA[Shaner]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[Norsworthy]]></surname>
<given-names><![CDATA[J. K.]]></given-names>
</name>
<name>
<surname><![CDATA[Ritz]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Review: Confirmation of resistance to herbicides and evaluation of resistance levels.]]></article-title>
<source><![CDATA[Weed Science]]></source>
<year>2013</year>
<volume>61</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>4-20</page-range></nlm-citation>
</ref>
<ref id="B2">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Davidian]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Giltinan]]></surname>
<given-names><![CDATA[D. M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Nonlinear models for repeated measurement data: an overview and update.]]></article-title>
<source><![CDATA[Journal of Agricultural, Biological, and Environmental Statistics]]></source>
<year>2003</year>
<volume>8</volume>
</nlm-citation>
</ref>
<ref id="B3">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Di Rienzo]]></surname>
<given-names><![CDATA[J. A.]]></given-names>
</name>
<name>
<surname><![CDATA[Casanoves]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
<name>
<surname><![CDATA[Balzarini]]></surname>
<given-names><![CDATA[M. G.]]></given-names>
</name>
<name>
<surname><![CDATA[Gonzalez]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[Cuadroda]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Robledo]]></surname>
<given-names><![CDATA[C. W.]]></given-names>
</name>
</person-group>
<source><![CDATA[Infostat (No. 2020)]]></source>
<year>2020</year>
<publisher-name><![CDATA[Centro de transferencia InfoStat]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B4">
<nlm-citation citation-type="journal">
<collab>European and Mediterranean Plant Protection Organization</collab>
<article-title xml:lang=""><![CDATA[Design and analysis of efficacy evaluation trials]]></article-title>
<source><![CDATA[EPPO Bulletin]]></source>
<year>2012</year>
<volume>42</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>367-81</page-range></nlm-citation>
</ref>
<ref id="B5">
<nlm-citation citation-type="journal">
<collab>European and Mediterranean Plant Protection Organization</collab>
<article-title xml:lang=""><![CDATA[PP 1/214 (4) Principles of acceptable efficacy]]></article-title>
<source><![CDATA[EPPO Bulletin]]></source>
<year>2017</year>
<volume>47</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>293-6</page-range></nlm-citation>
</ref>
<ref id="B6">
<nlm-citation citation-type="">
<collab>Food and Agriculture Organization of the United Nations</collab>
<source><![CDATA[Guidelines on efficacy data for the registration of pesticides for plant protection]]></source>
<year>2006</year>
</nlm-citation>
</ref>
<ref id="B7">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fox]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Weisberg]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
</person-group>
<source><![CDATA[An R companion to applied regression]]></source>
<year>2019</year>
<edition>3rd</edition>
<publisher-name><![CDATA[Sage]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B8">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gerhard]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[Ritz]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
</person-group>
<source><![CDATA[Marginalization in nonlinear mixed-effects models with an application to dose-response analysis]]></source>
<year>2017</year>
<publisher-name><![CDATA[arXiv]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B9">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Keshtkar]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[Kudsk]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[Mesgaran]]></surname>
<given-names><![CDATA[M. B.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Perspective: common errors in dose-response analysis and how to avoid them]]></article-title>
<source><![CDATA[Pest Management Science]]></source>
<year>2021</year>
<volume>77</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>2599-608</page-range></nlm-citation>
</ref>
<ref id="B10">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Leguizamon]]></surname>
<given-names><![CDATA[E. S.]]></given-names>
</name>
<name>
<surname><![CDATA[Ferrari]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
<name>
<surname><![CDATA[Williams]]></surname>
<given-names><![CDATA[M. M.]]></given-names>
</name>
<name>
<surname><![CDATA[Burgos]]></surname>
<given-names><![CDATA[N. R.]]></given-names>
</name>
<name>
<surname><![CDATA[Travlos]]></surname>
<given-names><![CDATA[I.]]></given-names>
</name>
<name>
<surname><![CDATA[Korres]]></surname>
<given-names><![CDATA[N. E.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Response of annual weeds to glyphosate: evaluation and optimization of application rate based on fecundity-avoidance biomass threshold criterion]]></article-title>
<source><![CDATA[Agronomy]]></source>
<year>2019</year>
<volume>9</volume>
<numero>12</numero>
<issue>12</issue>
</nlm-citation>
</ref>
<ref id="B11">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Nielsen]]></surname>
<given-names><![CDATA[O. K.]]></given-names>
</name>
<name>
<surname><![CDATA[Ritz]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Streibig]]></surname>
<given-names><![CDATA[J. C.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Nonlinear mixed-model regression to analyze herbicide dose-response relationships]]></article-title>
<source><![CDATA[Weed Technology]]></source>
<year>2004</year>
<volume>18</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>30-7</page-range></nlm-citation>
</ref>
<ref id="B12">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pinheiro]]></surname>
<given-names><![CDATA[J. C.]]></given-names>
</name>
<name>
<surname><![CDATA[Bates]]></surname>
<given-names><![CDATA[D. M.]]></given-names>
</name>
</person-group>
<source><![CDATA[Mixed-Effects models in S and S-PLUS]]></source>
<year>2000</year>
<publisher-name><![CDATA[Springer]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B13">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ramírez Muñoz]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
</person-group>
<source><![CDATA[Mecanismo de resistencia de Paspalum paniculatum L. (poaceae) al herbicida glifosato]]></source>
<year>2017</year>
<publisher-name><![CDATA[Instituto Tecnológico de Costa Rica]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B14">
<nlm-citation citation-type="book">
<collab>R Core Team</collab>
<source><![CDATA[R: A language and environment for statistical computing (No. 2024)]]></source>
<year>2024</year>
<publisher-name><![CDATA[R Foundation for Statistical Computing]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B15">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ritz]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Baty]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
<name>
<surname><![CDATA[Streibig]]></surname>
<given-names><![CDATA[J. C.]]></given-names>
</name>
<name>
<surname><![CDATA[Gerhard]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Dose-response analysis using R.]]></article-title>
<source><![CDATA[PLoS ONE]]></source>
<year>2015</year>
<volume>10</volume>
<numero>12</numero>
<issue>12</issue>
</nlm-citation>
</ref>
<ref id="B16">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ritz]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Jensen]]></surname>
<given-names><![CDATA[S. M.]]></given-names>
</name>
<name>
<surname><![CDATA[Gerhard]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[Streibig]]></surname>
<given-names><![CDATA[J. C.]]></given-names>
</name>
</person-group>
<source><![CDATA[Dose-response analysis using R]]></source>
<year>2019</year>
<edition>1st</edition>
<publisher-name><![CDATA[Chapman and Hall/CRC]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B17">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ryan]]></surname>
<given-names><![CDATA[T. P.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Planning, construction, and statistical analysis of comparative experiments.]]></article-title>
<source><![CDATA[Journal of Quality Technology]]></source>
<year>2004</year>
<volume>36</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>454-7</page-range></nlm-citation>
</ref>
<ref id="B18">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Schabenberger]]></surname>
<given-names><![CDATA[O.]]></given-names>
</name>
<name>
<surname><![CDATA[Tharp]]></surname>
<given-names><![CDATA[B. E.]]></given-names>
</name>
<name>
<surname><![CDATA[Kells]]></surname>
<given-names><![CDATA[J. J.]]></given-names>
</name>
<name>
<surname><![CDATA[Penner]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Statistical tests for hormesis and effective dosages in herbicide dose response.]]></article-title>
<source><![CDATA[Agronomy Journal]]></source>
<year>1999</year>
<volume>91</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>713-21</page-range></nlm-citation>
</ref>
<ref id="B19">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Seefeldt]]></surname>
<given-names><![CDATA[S. S.]]></given-names>
</name>
<name>
<surname><![CDATA[Jensen]]></surname>
<given-names><![CDATA[J. E.]]></given-names>
</name>
<name>
<surname><![CDATA[Fuerst]]></surname>
<given-names><![CDATA[E. P.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Log-logistic analysis of herbicide dose-response relationships]]></article-title>
<source><![CDATA[Weed Technology]]></source>
<year>1995</year>
<volume>9</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>218-27</page-range></nlm-citation>
</ref>
<ref id="B20">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Streibig]]></surname>
<given-names><![CDATA[J. C.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Models for curve-fitting herbicide dose response data]]></article-title>
<source><![CDATA[Acta Agriculturae Scandinavica]]></source>
<year>1980</year>
<volume>30</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>59-64</page-range></nlm-citation>
</ref>
<ref id="B21">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Szöcs]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[Schäfer]]></surname>
<given-names><![CDATA[R. B.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Ecotoxicology is not normal: A comparison of statistical approaches for analysis of count and proportion data in ecotoxicology]]></article-title>
<source><![CDATA[Environmental Science and Pollution Research]]></source>
<year>2015</year>
<volume>22</volume>
<page-range>13990-9</page-range></nlm-citation>
</ref>
<ref id="B22">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wickham]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
</person-group>
<source><![CDATA[ggplot2: Elegant graphics for data analysis]]></source>
<year>2016</year>
<edition>2nd</edition>
<publisher-name><![CDATA[Springer International Publishing]]></publisher-name>
</nlm-citation>
</ref>
</ref-list>
</back>
</article>
