<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2215-3470</journal-id>
<journal-title><![CDATA[Uniciencia]]></journal-title>
<abbrev-journal-title><![CDATA[Uniciencia]]></abbrev-journal-title>
<issn>2215-3470</issn>
<publisher>
<publisher-name><![CDATA[Universidad Nacional, Costa Rica]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2215-34702018000100032</article-id>
<article-id pub-id-type="doi">10.15359/ru.32-1.3</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Caracterización estructural de vesículas modificadas con quitosano]]></article-title>
<article-title xml:lang="en"><![CDATA[Structural Characterization of Chitosan Modified Vesicles]]></article-title>
<article-title xml:lang="pt"><![CDATA[Caracterização estrutural de vesículas modificadas com quitosana]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Soto-Cruz]]></surname>
<given-names><![CDATA[Jackeline]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Alvarado-Aguilar]]></surname>
<given-names><![CDATA[Patricia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vega-Baudrit]]></surname>
<given-names><![CDATA[Jose Roberto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Redondo-Gómez]]></surname>
<given-names><![CDATA[Carlos]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Soto-Tellini]]></surname>
<given-names><![CDATA[Victor]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Madrigal-Carballo]]></surname>
<given-names><![CDATA[Sergio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rojas-Carrillo]]></surname>
<given-names><![CDATA[Oscar]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional  ]]></institution>
<addr-line><![CDATA[Heredia ]]></addr-line>
<country>Costa Rica</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Nacional  ]]></institution>
<addr-line><![CDATA[Heredia ]]></addr-line>
<country>Costa Rica</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Laboratorio Nacional de Nanotecnología LANOTEC  ]]></institution>
<addr-line><![CDATA[San José ]]></addr-line>
<country>Costa Rica</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Laboratorio Nacional de Nanotecnología LANOTEC  ]]></institution>
<addr-line><![CDATA[San José ]]></addr-line>
<country>Costa Rica</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Universidad de Costa Rica  ]]></institution>
<addr-line><![CDATA[San José ]]></addr-line>
<country>Costa Rica</country>
</aff>
<aff id="Af6">
<institution><![CDATA[,Universidad Nacional  ]]></institution>
<addr-line><![CDATA[Heredia ]]></addr-line>
<country>Costa Rica</country>
</aff>
<aff id="Af7">
<institution><![CDATA[,Universidad Nacional  ]]></institution>
<addr-line><![CDATA[Heredia ]]></addr-line>
<country>Costa Rica</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2018</year>
</pub-date>
<volume>32</volume>
<numero>1</numero>
<fpage>32</fpage>
<lpage>45</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_arttext&amp;pid=S2215-34702018000100032&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_abstract&amp;pid=S2215-34702018000100032&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_pdf&amp;pid=S2215-34702018000100032&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen Vesículas a base de L-&#945;-fosfatidilcolina (PC) y mezclas de PC/fosfogliceroles fueron caracterizadas por medio de dispersión de luz dinámica (DLS), microscopía electrónica de barrido-criogénico (Cryo-SEM) y calorimetría de titulación isotérmica (ITC). La incorporación de fosfogliceroles en la formulación de vesículas a base PC disminuyó el tamaño y la polidispersidad de las partículas, debido a un mayor empaquetamiento de las cadenas alifáticas por medio de interacciones de van der Waals. Además, resultó en una disminución significativa de la carga superficial de -75 mV comparada con el potencial Z (&#958;) de las vesículas a base de PC. Ambos sistemas fueron modificados usando un polielectrolito catiónico (quitosano) de un peso molecular de 865 kDa y con un grado de desacetilación de 77 %. La naturaleza aniónica de la vesícula fosfolipídica resultó en una efectiva interacción con el polielectrolito catiónico mediante fuerzas del tipo electrostática, la cual fue determinada por medio de ITC. Los resultados fueron complementados mediante la determinación de potencial Z de los sistemas modificados, lo cual demostró que no es necesaria una inversión completa de la carga inicial de la superficie de la vesícula para asegurar el recubrimiento de esta. La adición de concentraciones de quitosano mayores a 0,1 mg/mL condujo a la agregación de las vesículas, lo cual fue demostrado mediante Cryo-SEM y DLS. Este efecto fue más significativo para el sistema basado en dimiristoilfosfoglicerol sal de sodio y quitosano, debido a la fuerte atracción electrostática.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract L-&#945;-phosphatidylcholine (PC) and PC/phosphoglycerol based-vesicles were characterized by Dynamic Light Scattering (DLS), Cryo-Scanning Electron Microscopy (Cryo-SEM), and Isotermal Titration calorimetry (ITC). The incorporation of phosphoglycerol into the PC vesicles decreased the size and the polydispersity of the particles, due to an increase of the packing of the aliphatic chains in the layer. This phenomenon has been interpreted in terms of strong van der Waals interactions. The addition of phosphoglycerols resulted in a reduction in zeta potential (&#958;) to values of -75 mV, compared to PC based-vesicles. Both systems were modified by using a high molecular weight chitosan (865 kDa) with a degree of deacetylation of 77%. Strong electrostatic interactions between the cationic polyelectrolyte and the vesicles were determined by ITC experiments. The results were reinforced by means of Z potential analysis. It has been demonstrated that a complete inverse of the vesicle surface charge is not required to perform a complete coating of the phospholipid particles. The addition of concentration of chitosan above 0,1 mg/mL induced vesicles aggregation. Aggregated vesicle-polymer structures were visualized by Cryo-SEM and measured by DLS. This behavior was more significant for the PC/DMPG-Na-/chitosan system.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo Vesículas a base de L-&#945;-fosfatidilcolina (PC) e mesclas de PC/fosfogliceróis foram caracterizadas por meio de dispersão de luz dinâmica (DLS), microscopia eletrônica de varredura-criogênico (Cryo-SEM) e calorimetria de titulação isotérmica (ITC). A incorporação de fosfogliceróis na formulação de vesículas a base de PC diminuiu o tamanho e a polidispersão das partículas, devido a um maior empacotamento das cadeias alifáticas por meio de interações de van der Waals. Além disso, resultou em uma diminuição significativa da carga superficial de -75 mV comparada com o potencial Z (&#958;) das vesículas a base de PC. Ambos os sistemas foram modificados usando um polieletrólito catiônico (quitosana) de um peso molecular de 865 kDa e com um grau de desacetilação de 77 %. A natureza aniônica da vesícula fosfolipídica resultou em uma interação efetiva com o polieletrólito catiônico através de forças do tipo eletrostática, que foi determinada por meio de ITC. Os resultados foram complementados por meio da determinação de potencial Z dos sistemas modificados, o qual demostrou não ser necessária uma inversão completa da carga inicial da superfície da vesícula para assegurar o recobrimento desta. A adição de concentrações de quitosana maiores a 0,1 mg/mL conduziu à agregação das vesículas, o qual foi demostrado mediante Cryo-SEM e DLS. Este efeito foi mais significativo para o sistema baseado em dimiristoil fosfoglicerol sal de sódio e quitosana, devido à forte atração eletrostática.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Vesículas]]></kwd>
<kwd lng="es"><![CDATA[quitosomas]]></kwd>
<kwd lng="es"><![CDATA[fosfolípidos]]></kwd>
<kwd lng="es"><![CDATA[polielectrolitos]]></kwd>
<kwd lng="es"><![CDATA[modificación de superficies]]></kwd>
<kwd lng="en"><![CDATA[vesicles]]></kwd>
<kwd lng="en"><![CDATA[chitosomes]]></kwd>
<kwd lng="en"><![CDATA[phospholipids]]></kwd>
<kwd lng="en"><![CDATA[polyelectrolytes]]></kwd>
<kwd lng="en"><![CDATA[surface modification]]></kwd>
<kwd lng="pt"><![CDATA[Vesículas]]></kwd>
<kwd lng="pt"><![CDATA[quitosomas]]></kwd>
<kwd lng="pt"><![CDATA[fosfolipídios]]></kwd>
<kwd lng="pt"><![CDATA[polieletrólitos]]></kwd>
<kwd lng="pt"><![CDATA[modificação de superfícies]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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