<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2215-3411</journal-id>
<journal-title><![CDATA[Odovtos International Journal of Dental Sciences]]></journal-title>
<abbrev-journal-title><![CDATA[Odovtos]]></abbrev-journal-title>
<issn>2215-3411</issn>
<publisher>
<publisher-name><![CDATA[Facultad de Odontología. Universidad de Costa Rica]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2215-34112025000300071</article-id>
<article-id pub-id-type="doi">10.15517/ijds.2025.65145</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Effectiveness and safety profile of short-term NSAIDs protocols in dental implantology. A systematic review of clinical evidence]]></article-title>
<article-title xml:lang="es"><![CDATA[Efectividad y perfil de seguridad del uso a corto plazo de protocolos con AINEs en implantología. Revisión sistemática de la evidencia clínica]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bueso-Ruiz]]></surname>
<given-names><![CDATA[Mario]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Montero-Aguilar]]></surname>
<given-names><![CDATA[Mauricio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Esparza-Villalpando]]></surname>
<given-names><![CDATA[Vicente]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pozos-Guillén]]></surname>
<given-names><![CDATA[Amaury]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Chavarría-Bolaños]]></surname>
<given-names><![CDATA[Daniel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Costa Rica Postgraduate Program in Dentistry ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Costa Rica</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Autónoma de Aguascalientes  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad Autónoma de San Luis Potosí Faculty of Dentistry ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2025</year>
</pub-date>
<volume>27</volume>
<numero>3</numero>
<fpage>71</fpage>
<lpage>85</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_arttext&amp;pid=S2215-34112025000300071&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_abstract&amp;pid=S2215-34112025000300071&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_pdf&amp;pid=S2215-34112025000300071&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract This systematic review aimed to assess the clinical effectiveness and biological safety of short-term non-steroidal anti-inflammatory drugs (NSAIDs) in managing postoperative pain following dental implant surgery. A comprehensive literature search was conducted across eight databases through March 2023, following PRISMA guidelines. Only randomized controlled trials (RCTs) evaluating short- term (&#8804;7 days) NSAID use in patients undergoing dental implant placement were included. Outcomes assessed included postoperative pain, swelling, need for rescue medication, patient satisfaction, adverse events, and effects on osseointegration. Risk of bias was assessed using GRADE and OCEMB tools. Ten RCTs met the inclusion criteria. NSAIDs studied included ibuprofen, naproxen, meloxicam, piroxicam, lornoxicam, dexketoprofen, and diclofenac. Most studies reported reduced postoperative pain and lower need for rescue medication with NSAIDs compared to placebo. Several trials also found higher patient satisfaction and reduced swelling. No significant adverse effects on marginal bone loss or osseointegration were observed in the short term. Risk of bias varied: three studies were low risk, four had some concerns, and three had high risk due to inadequate blinding or unclear randomization. The short-term use of NSAIDs appears to be effective in reducing postoperative pain and swelling after dental implant placement without negatively affecting osseointegration. However, heterogeneity in study design, protocols, and outcomes prevented meta-analysis. Further high-quality RCTs with standardized protocols are needed to establish clear clinical guidelines.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen Esta revisión sistemática tuvo como objetivo evaluar la efectividad clínica y el perfil de seguridad biológica del uso a corto plazo de medicamentos antiinflamatorios no esteroideos (AINEs) en el manejo del dolor postoperatorio tras la colocación de implantes dentales. Se realizó una búsqueda exhaustiva de literatura en ocho bases de datos hasta marzo de 2023, siguiendo las directrices PRISMA. Se incluyeron únicamente ensayos clínicos aleatorizados (ECA) que evaluaran el uso a corto plazo (&#8804;7 días) de AINEs en pacientes sometidos a cirugía de implantes dentales. Se analizaron variables como el dolor postoperatorio, inflamación, necesidad de medicación de rescate, satisfacción del paciente, eventos adversos y efectos sobre la oseointegración. El riesgo de sesgo se evaluó mediante las herramientas GRADE y OCEMB. Diez ECA cumplieron con los criterios de inclusión. Los AINEs evaluados incluyeron ibuprofeno, naproxeno, meloxicam, piroxicam, lornoxicam, dexketoprofeno y diclofenaco. La mayoría de los estudios reportaron una reducción del dolor postoperatorio y menor necesidad de medicación de rescate con AINEs en comparación con placebo. Varios ensayos también evidenciaron mayor satisfacción del paciente y menor inflamación. No se observaron efectos adversos significativos en la pérdida ósea marginal ni en la oseointegración en el corto plazo. El riesgo de sesgo fue variable: tres estudios presentaron bajo riesgo, cuatro mostraron algunas preocupaciones y tres presentaron alto riesgo debido a un cegamiento inadecuado o aleatorización poco clara. El uso a corto plazo de AINEs parece ser eficaz para reducir el dolor y la inflamación postoperatoria tras la colocación de implantes dentales, sin afectar negativamente la oseointegración. Sin embargo, la heterogeneidad en los diseños, protocolos y resultados de los estudios impidió realizar un metaanálisis. Se necesitan ECA de alta calidad con protocolos estandarizados para establecer recomendaciones clínicas claras.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Dental implants]]></kwd>
<kwd lng="en"><![CDATA[NSAIDs]]></kwd>
<kwd lng="en"><![CDATA[Postoperative pain]]></kwd>
<kwd lng="en"><![CDATA[Osseointegration]]></kwd>
<kwd lng="en"><![CDATA[Short-term analgesia]]></kwd>
<kwd lng="es"><![CDATA[Implantes dentales]]></kwd>
<kwd lng="es"><![CDATA[AINES]]></kwd>
<kwd lng="es"><![CDATA[Dolor postoperatorio]]></kwd>
<kwd lng="es"><![CDATA[Oseointegración]]></kwd>
<kwd lng="es"><![CDATA[Analgesia de corto plazo]]></kwd>
</kwd-group>
</article-meta>
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