<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2215-3411</journal-id>
<journal-title><![CDATA[Odovtos International Journal of Dental Sciences]]></journal-title>
<abbrev-journal-title><![CDATA[Odovtos]]></abbrev-journal-title>
<issn>2215-3411</issn>
<publisher>
<publisher-name><![CDATA[Facultad de Odontología. Universidad de Costa Rica]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2215-34112025000300059</article-id>
<article-id pub-id-type="doi">10.15517/ijds.2025.65076</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Neural network-based prediction of hub genes in the interactome of hereditary gingival fibromatosis: an AI-driven bioinformatics study]]></article-title>
<article-title xml:lang="es"><![CDATA[Predicción basada en redes neuronales de genes Hub en el interactoma de la fibromatosis gingival hereditaria: un estudio de bioinformática impulsado por IA]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Arumuganainar]]></surname>
<given-names><![CDATA[Deepavalli]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Yadalam]]></surname>
<given-names><![CDATA[Pradeep K.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ardila]]></surname>
<given-names><![CDATA[Carlos M.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Saveetha. University Saveetha Dental College, Saveetha Institute of Medical and technology sciences, SIMATS Department of Periodontics]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>India</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Antioquia U de A Faculty of Dentistry Department of Basic Sciences]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2025</year>
</pub-date>
<volume>27</volume>
<numero>3</numero>
<fpage>59</fpage>
<lpage>70</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_arttext&amp;pid=S2215-34112025000300059&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_abstract&amp;pid=S2215-34112025000300059&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_pdf&amp;pid=S2215-34112025000300059&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Hereditary gingival fibromatosis (HGF) is a rare genetic disorder characterized by excessive gum growth, often presenting in childhood or adolescence. Symptoms include difficulties in speech, eating, oral hygiene, and psychological distress. Understanding the molecular mechanisms behind HGF is crucial for identifying potential therapeutic targets. This study aimed to predict interactomic hub genes in HGF using neural networks. We analyzed the GEO dataset GSE4250 using the geor2 tool to identify differentially expressed genes. Cytoscape and the CytoHubba plugin were employed to construct the interactome, ranking hub genes based on centrality scores. A neural network model with an 80:20 train- test split was used to predict hub and non-hub genes, achieving an AUC of 0.853, classification accuracy of 0.720, F1 score of 0.720, precision of 0.720, and recall of 0.720. The resulting network consisted of 147 nodes and 1092 edges, demonstrating moderate heterogeneity and connectivity. Ten key hub genes were identified, offering insights into the molecular basis of HGF. While the neural network model shows promising predictive capacity, further validation in larger cohorts is required. Adding predictive features and functional validation experiments could deepen understanding of HGF's biological mechanisms.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La fibromatosis gingival hereditaria (FGH) es un trastorno genético raro caracterizado por un crecimiento excesivo de las encías, que suele manifestarse en la infancia o adolescencia. Los síntomas incluyen dificultades en el habla, la alimentación, la higiene oral y angustia psicológica. Comprender los mecanismos moleculares subyacentes a la FGH es crucial para identificar posibles dianas terapéuticas. Este estudio tuvo como objetivo predecir genes hub en el interactoma de la FGH utilizando redes neuronales. Analizamos el conjunto de datos GEO GSE4250 mediante la herramienta geor2 para identificar genes diferencialmente expresados. Se emplearon Cytoscape y el complemento CytoHubba para construir el interactoma, clasificando los genes hub según puntuaciones de centralidad. Se utilizó un modelo de red neuronal con una división 80:20 entrenamiento-prueba para predecir genes hub y no hub, logrando un AUC de 0.853, una precisión de clasificación de 0.720, un F1-score de 0.720, una precisión de 0.720 y una exhaustividad de 0.720. La red resultante constó de 147 nodos y 1092 aristas, mostrando una heterogeneidad y conectividad moderadas. Se identificaron diez genes hub clave, lo que aporta información sobre las bases moleculares de la FGH. Aunque el modelo de red neuronal muestra una capacidad predictiva prometedora, se requiere validación en cohortes más grandes. La incorporación de características predictivas adicionales y experimentos de validación funcional podría profundizar en la comprensión de los mecanismos biológicos de la FGH.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Hereditary gingival fibromatosis]]></kwd>
<kwd lng="en"><![CDATA[Neural networks]]></kwd>
<kwd lng="en"><![CDATA[Gene expression profiling]]></kwd>
<kwd lng="en"><![CDATA[Protein- protein interactions]]></kwd>
<kwd lng="en"><![CDATA[Hub genes]]></kwd>
<kwd lng="en"><![CDATA[Protein interaction maps]]></kwd>
<kwd lng="es"><![CDATA[Fibromatosis gingival hereditaria]]></kwd>
<kwd lng="es"><![CDATA[Redes neuronales]]></kwd>
<kwd lng="es"><![CDATA[Perfilación de expresión génica]]></kwd>
<kwd lng="es"><![CDATA[Interacciones proteína-proteína]]></kwd>
<kwd lng="es"><![CDATA[Genes hub]]></kwd>
<kwd lng="es"><![CDATA[Redes de interacción de proteínas]]></kwd>
</kwd-group>
</article-meta>
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