<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2215-3411</journal-id>
<journal-title><![CDATA[Odovtos International Journal of Dental Sciences]]></journal-title>
<abbrev-journal-title><![CDATA[Odovtos]]></abbrev-journal-title>
<issn>2215-3411</issn>
<publisher>
<publisher-name><![CDATA[Facultad de Odontología. Universidad de Costa Rica]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2215-34112023000200078</article-id>
<article-id pub-id-type="doi">10.15517/ijds.2023.53752</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Autophagic-Related anticancer effect of grapes extract and tomatoes extract: Ex-Vivo study]]></article-title>
<article-title xml:lang="es"><![CDATA[Efecto anticancerígeno relacionado con el autofago del extracto de uva y el extracto de tomate: estudio ex vivo]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Elshafei]]></surname>
<given-names><![CDATA[Marwa M.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Helmy]]></surname>
<given-names><![CDATA[Iman M.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sayed]]></surname>
<given-names><![CDATA[Marwa M.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Farag]]></surname>
<given-names><![CDATA[Doaa B.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Shebl]]></surname>
<given-names><![CDATA[Ismail M.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ghazy]]></surname>
<given-names><![CDATA[Shaimaa E.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Afifi]]></surname>
<given-names><![CDATA[Nermeen S.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Misr International University Faculty of Oral and Dental Medicine Department of Oral Histopathology]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Egypt</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Ain Shams University Faculty of Dentistry Department of Oral Pathology]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Egypt</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Ain Shams University Faculty of Medicine Department of Biochemistry]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Egypt</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Misr International University Faculty of Pharmacy Department of Pharmaceutical Chemistry]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Egypt</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Misr International University Faculty of Oral and Dental Medicine Department of Oral Histopathology]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Egypt</country>
</aff>
<aff id="Af6">
<institution><![CDATA[,Ain Shams University Faculty of Dentistry Department of Oral Pathology]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Egypt</country>
</aff>
<aff id="Af7">
<institution><![CDATA[,Ain Shams University Faculty of Dentistry Department of Oral Pathology]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Egypt</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2023</year>
</pub-date>
<volume>25</volume>
<numero>2</numero>
<fpage>78</fpage>
<lpage>92</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_arttext&amp;pid=S2215-34112023000200078&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_abstract&amp;pid=S2215-34112023000200078&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_pdf&amp;pid=S2215-34112023000200078&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract: Cells undergo autophagy to save themselves from injury, but progressive autophagy can cause cell death. This study characterized and compared the effect of grape (resveratrol) and tomato (lycopene) extracts and their combination on modulating autophagy-related miRNA and its target gene in squamous cell carcinoma cell line. Docking analysis for extracts and selected genes was performed. Methyl Thiazol Tetrazolium assays were used to assess the cytotoxicity of extracts and their combination toward HEp-2 cells. qRT-PCR was used to quantify changes in gene expression. Data were statistically analyzed. miRNA-20a was identified as a potential effector in laryngeal cancer, and sequestosome-1 (SQSTM1) was its target gene. Docking analysis showed that resveratrol interacted with miRNA-20a and showed less affinity toward SQSTM1. Hydrogen bonds and hydrophobic interactions were predicted. In contrast, lycopene showed less affinity toward miRNA-20a than resveratrol. Increasing doses of resveratrol, lycopene, and their combination induced a statistically significant reduction in mean percent viability and mean fold changes of miRNA-20a and SQSTM1 expression in treated HEp-2 cells. Pearson's correlation showed a statistically significant positive correlation between miRNA-20a and SQSTM1 (R=0.812, p&#8804;0.001). Grape and tomato extracts and their combination display promising cytotoxicity against HEp-2 cells in a dose- and time-dependent fashion. Both extracts reduce the expression of miRNA-20a and SQSTM1 with subsequent inhibition autophagy and promotion of apoptosis in HEp-2 cells.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: Las células se someten a autofagia para salvarse de lesiones, pero la autofagia progresiva puede provocar la muerte celular. Este estudio caracterizó y comparó el efecto de los extractos de uva (resveratrol) y tomate (licopeno) y su combinación en la modulación de miARN relacionado con la autofagia y su gen diana en la línea celular de carcinoma de células escamosas. Se realizó análisis de acoplamiento para extractos y genes seleccionados. Se utilizaron ensayos de metil tiazol tetrazolio para evaluar la citotoxicidad de los extractos y su combinación frente a las células HEp-2. qRT-PCR se utilizó para cuantificar los cambios en la expresión génica. Los datos fueron analizados estadísticamente. El miARN-20a se identificó como un efector potencial en el cáncer de laringe y el secuenciasoma-1 (SQSTM1) fue su gen diana. El análisis de acoplamiento mostró que el resveratrol interactuaba con miRNA-20a y mostraba menos afinidad hacia SQSTM1. Se predijeron enlaces de hidrógeno e interacciones hidrofóbicas. Por el contrario, el licopeno mostró menos afinidad hacia el miARN-20a que el resveratrol. El aumento de las dosis de resveratrol, licopeno y su combinación indujo una reducción estadísticamente significativa en el porcentaje medio de viabilidad y los cambios medios en la expresión de miRNA- 20a y SQSTM1 en las células HEp-2 tratadas. La correlación de Pearson mostró una correlación positiva estadísticamente significativa entre miRNA-20a y SQSTM1 (R=0,812, p&#8804;0,001). Los extractos de uva y tomate y su combinación muestran una citotoxicidad prometedora contra las células HEp-2 de forma dependiente de la dosis y el tiempo. Ambos extractos reducen la expresión de miRNA-20a y SQSTM1 con la posterior inhibición de la autofagia y promoción de la apoptosis en células HEp-2.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[HEp-2]]></kwd>
<kwd lng="en"><![CDATA[Resveratrol]]></kwd>
<kwd lng="en"><![CDATA[Lycopene]]></kwd>
<kwd lng="en"><![CDATA[miRNA-20a]]></kwd>
<kwd lng="en"><![CDATA[SQSTM1]]></kwd>
<kwd lng="es"><![CDATA[HEp-2]]></kwd>
<kwd lng="es"><![CDATA[Resveratrol]]></kwd>
<kwd lng="es"><![CDATA[Licopeno]]></kwd>
<kwd lng="es"><![CDATA[miRNA-20a]]></kwd>
<kwd lng="es"><![CDATA[SQSTM1]]></kwd>
</kwd-group>
</article-meta>
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