<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2215-3411</journal-id>
<journal-title><![CDATA[Odovtos International Journal of Dental Sciences]]></journal-title>
<abbrev-journal-title><![CDATA[Odovtos]]></abbrev-journal-title>
<issn>2215-3411</issn>
<publisher>
<publisher-name><![CDATA[Facultad de Odontología. Universidad de Costa Rica]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2215-34112017000100043</article-id>
<article-id pub-id-type="doi">10.15517/ijds.v0i0.28074</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Carcinoma oral de células escamosas diagnosticado precozmente: Reporte de caso y revisión de literatura]]></article-title>
<article-title xml:lang="en"><![CDATA[Oral Carcinoma of Squamous Cells with Early Diagnosis: Case Report and Literature Review]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Oreamuno]]></surname>
<given-names><![CDATA[Yadira V. Boza]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Costa Rica Facultad de Odontología ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>CR</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2017</year>
</pub-date>
<volume>19</volume>
<numero>1</numero>
<fpage>43</fpage>
<lpage>50</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_arttext&amp;pid=S2215-34112017000100043&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_abstract&amp;pid=S2215-34112017000100043&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_pdf&amp;pid=S2215-34112017000100043&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[ResumenEl carcinoma oral de células escamosas (COCE) es la neoplasia maligna más común de origen epitelial en la cavidad bucal, suele afectar en su mayoría a hombres mayores de 40 años de edad. Los sitios de localización más frecuentes son la lengua y el piso de la boca. La etiología es multifactorial siendo el tabaco y el alcohol los factores de riesgo más importantes. La presentación clínica es variable y aunque es precedido por cambios visibles en la mucosa oral el diagnóstico suele realizarse de forma tardía. Un diagnóstico precoz es de importancia crítica para mejorar la sobrevida y los resultados del tratamiento. El tamizaje del cáncer bucal es efectivo al reducir la mortalidad y morbilidad de cáncer bucal. El objetivo de este trabajo es presentar un caso de COCE y evidenciar la importancia de un diagnóstico precoz utilizando el tamizaje de cáncer bucal, así como la revisión de literatura en cuanto a esta patología.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[AbstractOral squamous cell carcinoma (OSCC) is the most common malignant neoplasm of epithelial origin in the oral cavity, usually affecting men over 40 years of age. The most frequent localization sites are the tongue and the floor of the mouth. The etiology is multifactorial being tobacco and alcohol the most important risk factors. The clinical presentation is variable and although it is preceded by visible changes in the oral mucosa, the diagnosis is usually made late. An early diagnosis is critically important to improve survival and treatment outcomes. Oral cancer screening is effective in reducing the mortality and morbidity of oral cancer. The purpose of this study was to present a case of OSCC and to highlight the importance of an early diagnosis using oral cancer screening, and the review of the relevant literature as for this pathology.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Cáncer]]></kwd>
<kwd lng="es"><![CDATA[Carcinoma oral de células escamosas]]></kwd>
<kwd lng="es"><![CDATA[Diagnóstico precoz]]></kwd>
<kwd lng="en"><![CDATA[Cancer]]></kwd>
<kwd lng="en"><![CDATA[Oral squamous cell carcinoma]]></kwd>
<kwd lng="en"><![CDATA[Early diagnosis]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Oral cancer: Clinical features]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bagan]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Sarrion]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
<name>
<surname><![CDATA[Jimenez]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
</person-group>
<source><![CDATA[Oral Oncol]]></source>
<year>2010</year>
<volume>46</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>414-7</page-range></nlm-citation>
</ref>
<ref id="B2">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Interaction between tobacco and alcohol use and the risk ofhead and neck cancer: pooledanalysis in the International Head and Neck Cancer Epidemiology Consortium]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hashibe]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Brennan]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[Chuang]]></surname>
<given-names><![CDATA[S. C.]]></given-names>
</name>
<name>
<surname><![CDATA[Boccia]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Castellsague]]></surname>
<given-names><![CDATA[X.]]></given-names>
</name>
<name>
<surname><![CDATA[Chen]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Curado]]></surname>
<given-names><![CDATA[M. P.]]></given-names>
</name>
<name>
<surname><![CDATA[Dal Maso]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[Daudt]]></surname>
<given-names><![CDATA[A. W.]]></given-names>
</name>
<name>
<surname><![CDATA[Fabianova]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[Fernandez]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[Wünsch-Filho]]></surname>
<given-names><![CDATA[V.]]></given-names>
</name>
<name>
<surname><![CDATA[Franceschi]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Hayes]]></surname>
<given-names><![CDATA[R. B]]></given-names>
</name>
<name>
<surname><![CDATA[Herrero]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Kelsey]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
<name>
<surname><![CDATA[Koifman]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[La Vecchia]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Lazarus]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[Levi]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
<name>
<surname><![CDATA[Lence]]></surname>
<given-names><![CDATA[J. J.]]></given-names>
</name>
<name>
<surname><![CDATA[Mates]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[Matos]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[Menezes]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[McClean]]></surname>
<given-names><![CDATA[M. D.]]></given-names>
</name>
<name>
<surname><![CDATA[Muscat]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Eluf-Neto]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Olshan]]></surname>
<given-names><![CDATA[A. F.]]></given-names>
</name>
<name>
<surname><![CDATA[Purdue]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Rudnai]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[Schwartz]]></surname>
<given-names><![CDATA[S. M.]]></given-names>
</name>
<name>
<surname><![CDATA[Smith]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[Sturgis]]></surname>
<given-names><![CDATA[E. M.]]></given-names>
</name>
<name>
<surname><![CDATA[Szeszenia-Dabrowska]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
<name>
<surname><![CDATA[Talamini]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Wei]]></surname>
<given-names><![CDATA[Q.]]></given-names>
</name>
<name>
<surname><![CDATA[Winn]]></surname>
<given-names><![CDATA[D. M.]]></given-names>
</name>
<name>
<surname><![CDATA[Shangina]]></surname>
<given-names><![CDATA[O.]]></given-names>
</name>
<name>
<surname><![CDATA[Pilarska]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[Z. F.]]></given-names>
</name>
<name>
<surname><![CDATA[Ferro]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
<name>
<surname><![CDATA[Berthiller]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Boffetta]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<source><![CDATA[Cancer Epidemiol Biomarkers Prev]]></source>
<year>2009</year>
<volume>18</volume>
<page-range>541-50</page-range></nlm-citation>
</ref>
<ref id="B3">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Population attributable risk of tobacco and alcohol for upper aerodigestive tract cancer]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Anantharaman]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[Marron]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Lagiou]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[Samoli]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[Ahrens]]></surname>
<given-names><![CDATA[W.]]></given-names>
</name>
<name>
<surname><![CDATA[Pohlabeln]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
<name>
<surname><![CDATA[Slamova]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Schejbalova]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Merletti]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
<name>
<surname><![CDATA[Richiardi]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[Kjaerheim]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
<name>
<surname><![CDATA[Castellsague]]></surname>
<given-names><![CDATA[X.]]></given-names>
</name>
<name>
<surname><![CDATA[Agudo]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Talamini]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Barzan]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[Macfarlane]]></surname>
<given-names><![CDATA[T. V.]]></given-names>
</name>
<name>
<surname><![CDATA[Tickle]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Simonato]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[Canova]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Conway]]></surname>
<given-names><![CDATA[D. I.]]></given-names>
</name>
<name>
<surname><![CDATA[McKinney]]></surname>
<given-names><![CDATA[P. A.]]></given-names>
</name>
<name>
<surname><![CDATA[Thomson]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[Znaor]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Healy]]></surname>
<given-names><![CDATA[C. M.]]></given-names>
</name>
<name>
<surname><![CDATA[McCartan]]></surname>
<given-names><![CDATA[B. E.]]></given-names>
</name>
<name>
<surname><![CDATA[Hashibe]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Brennan]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[Macfarlane]]></surname>
<given-names><![CDATA[G. J]]></given-names>
</name>
</person-group>
<source><![CDATA[Oral Oncol]]></source>
<year>2011</year>
<volume>47</volume>
<page-range>725-31</page-range></nlm-citation>
</ref>
<ref id="B4">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Barboza]]></surname>
<given-names><![CDATA[I.]]></given-names>
</name>
<name>
<surname><![CDATA[Camacho]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Gutiérrez]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
<name>
<surname><![CDATA[Tacsan]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<source><![CDATA[Epidemiología del cáncer bucal en Costa Rica en el período de 1981-1994]]></source>
<year>1997</year>
<publisher-loc><![CDATA[Costa Rica ]]></publisher-loc>
<publisher-name><![CDATA[Facultad de Odontología, Universidad de Costa Rica]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B5">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Cancer Statistics 2002]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jemal]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Thomas]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Murray]]></surname>
<given-names><![CDATA[T.]]></given-names>
</name>
</person-group>
<source><![CDATA[CA Cancer J Clin]]></source>
<year>2002</year>
<volume>52</volume>
<page-range>6-7</page-range></nlm-citation>
</ref>
<ref id="B6">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Trends in frequency and prevalence of oral cancer and oral squamous cell carcinoma in Mexicans. A 20 years retrospective study]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gaitán Cepeda]]></surname>
<given-names><![CDATA[L. A.]]></given-names>
</name>
<name>
<surname><![CDATA[Peniche Becerra]]></surname>
<given-names><![CDATA[A. G.]]></given-names>
</name>
<name>
<surname><![CDATA[Quezada Rivera]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<source><![CDATA[Med Oral Patol Oral Cir Bucal]]></source>
<year>2011</year>
<volume>16</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>1-5</page-range></nlm-citation>
</ref>
<ref id="B7">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Clinical features and evolution of oral cancer: A study of 274 cases in Buenos Aires, Argentina]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Brandizzi]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[Gandolfo]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Velazco]]></surname>
<given-names><![CDATA[M. L.]]></given-names>
</name>
<name>
<surname><![CDATA[Cabrini]]></surname>
<given-names><![CDATA[R. L.]]></given-names>
</name>
<name>
<surname><![CDATA[Lanfranchi]]></surname>
<given-names><![CDATA[H. E]]></given-names>
</name>
</person-group>
<source><![CDATA[Med Oral Patol Oral Cir Bucal]]></source>
<year>2008</year>
<volume>13</volume>
<page-range>544-8</page-range></nlm-citation>
</ref>
<ref id="B8">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Malignant transformation of oral epithelial dysplasia: a real-world evaluation of histopathologic grading]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Dost]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
<name>
<surname><![CDATA[Le Cao]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
<name>
<surname><![CDATA[Ford]]></surname>
<given-names><![CDATA[P. J.]]></given-names>
</name>
<name>
<surname><![CDATA[Ades]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Farah]]></surname>
<given-names><![CDATA[C. S]]></given-names>
</name>
</person-group>
<source><![CDATA[Oral Surg Oral Med Oral Pathol Oral Radiol]]></source>
<year>2014</year>
<volume>117</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>343-52</page-range></nlm-citation>
</ref>
<ref id="B9">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Oral epithelial dysplasia classification systems: predictive value, utility, weaknesses and scope for improvement]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Warnakulasuriya]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Reibel]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Bouquot]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Dabelsteen]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<source><![CDATA[J Oral Pathol Med]]></source>
<year>2008</year>
<volume>37</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>127-33</page-range></nlm-citation>
</ref>
<ref id="B10">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Nomenclature and classification of potentially malignant disorders of the oral mucosa]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Warnakulasuriya]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Johnson]]></surname>
<given-names><![CDATA[N.W.]]></given-names>
</name>
<name>
<surname><![CDATA[van der Waal]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
</person-group>
<source><![CDATA[J Oral Pathol Med]]></source>
<year>2007</year>
<volume>36</volume>
<page-range>575-80</page-range></nlm-citation>
</ref>
<ref id="B11">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Screening for and diagnosis of oral premalignant lesions and oropharyngeal squamous cell carcinoma. Role of primary care physicians]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Epstein]]></surname>
<given-names><![CDATA[Joel. B.]]></given-names>
</name>
<name>
<surname><![CDATA[Gorsky]]></surname>
<given-names><![CDATA[Meir.]]></given-names>
</name>
<name>
<surname><![CDATA[Cabay]]></surname>
<given-names><![CDATA[Robert J.]]></given-names>
</name>
<name>
<surname><![CDATA[Day]]></surname>
<given-names><![CDATA[Terry.]]></given-names>
</name>
<name>
<surname><![CDATA[Gonsalves]]></surname>
<given-names><![CDATA[Wanda]]></given-names>
</name>
</person-group>
<source><![CDATA[Can Fam Physician]]></source>
<year>2008</year>
<volume>54</volume>
<page-range>870-5</page-range></nlm-citation>
</ref>
<ref id="B12">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Natural history of potentially malignant oral lesions and conditions: an overview of the literature]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Napier]]></surname>
<given-names><![CDATA[S. S.]]></given-names>
</name>
<name>
<surname><![CDATA[Speight]]></surname>
<given-names><![CDATA[P. M]]></given-names>
</name>
</person-group>
<source><![CDATA[J Oral Pathol Med]]></source>
<year>2008</year>
<volume>37</volume>
<page-range>1-10</page-range></nlm-citation>
</ref>
<ref id="B13">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Malignant transformation of oral epithelial dysplasia: a real-world evaluation of histopathologic grading]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Dost]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
<name>
<surname><![CDATA[Le Cao]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
<name>
<surname><![CDATA[Ford]]></surname>
<given-names><![CDATA[P. J.]]></given-names>
</name>
<name>
<surname><![CDATA[Ades]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Farah]]></surname>
<given-names><![CDATA[C. S]]></given-names>
</name>
</person-group>
<source><![CDATA[Oral Surg Oral Med Oral Pathol Oral Radiol]]></source>
<year>2014</year>
<volume>117</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>343-52</page-range></nlm-citation>
</ref>
<ref id="B14">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Oral cancer and precancerous lesions]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Neville]]></surname>
<given-names><![CDATA[B. W.]]></given-names>
</name>
<name>
<surname><![CDATA[Day]]></surname>
<given-names><![CDATA[T. A]]></given-names>
</name>
</person-group>
<source><![CDATA[CA Cancer J Clin]]></source>
<year>2002</year>
<volume>52</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>195-215</page-range></nlm-citation>
</ref>
<ref id="B15">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Predictive value of dysplasia grading and DNA ploidy in malignant transformation of oral potentially malignant disorders]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sperandio]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Brown]]></surname>
<given-names><![CDATA[A. L.]]></given-names>
</name>
<name>
<surname><![CDATA[Lock]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Morgan]]></surname>
<given-names><![CDATA[P. R.]]></given-names>
</name>
<name>
<surname><![CDATA[Coupland]]></surname>
<given-names><![CDATA[V. H.]]></given-names>
</name>
<name>
<surname><![CDATA[Madden]]></surname>
<given-names><![CDATA[P. B.]]></given-names>
</name>
</person-group>
<source><![CDATA[Cancer Prev Res (Phila)]]></source>
<year>2001</year>
<volume>6</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>822-31</page-range></nlm-citation>
</ref>
<ref id="B16">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Assesing the patient at risk for oral squamous cell carcinoma]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Epstein]]></surname>
<given-names><![CDATA[J. B.]]></given-names>
</name>
<name>
<surname><![CDATA[Scully]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<source><![CDATA[Spec Care Dent]]></source>
<year>1997</year>
<volume>17</volume>
<page-range>120-8</page-range></nlm-citation>
</ref>
<ref id="B17">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Effect of screening on oral cancer mortality in Kerala, India: a clusterrandomised controlled trial]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sankaranarayanan]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Ramadas]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
<name>
<surname><![CDATA[Thomas]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
<name>
<surname><![CDATA[Muwonge]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Thara]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Mathew]]></surname>
<given-names><![CDATA[B.]]></given-names>
</name>
</person-group>
<source><![CDATA[The Lancet]]></source>
<year>2005</year>
<volume>365</volume>
<numero>9475</numero>
<issue>9475</issue>
<page-range>1927-33</page-range></nlm-citation>
</ref>
<ref id="B18">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Guideline for the early detection of oral cancer in British Columbia 2008]]></article-title>
<collab>British Columbia Oral Cancer Prevention Program</collab>
<collab>BC Cancer Agency</collab>
<collab>College of Dental Surgeons of British Columbia</collab>
<source><![CDATA[J Can Dent Assoc]]></source>
<year>2008</year>
<volume>74</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>245-53</page-range></nlm-citation>
</ref>
<ref id="B19">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Frecuencia de displasia epitelial y carcinoma escamoso en mucosa oral y orofaríngea en Chile, entre los años 1990 y 2009]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Martinez]]></surname>
<given-names><![CDATA[Carolina.]]></given-names>
</name>
<name>
<surname><![CDATA[Hernandez]]></surname>
<given-names><![CDATA[Marcela.]]></given-names>
</name>
<name>
<surname><![CDATA[Martinez]]></surname>
<given-names><![CDATA[Benjamín.]]></given-names>
</name>
<name>
<surname><![CDATA[Adorno]]></surname>
<given-names><![CDATA[Daniela]]></given-names>
</name>
</person-group>
<source><![CDATA[Rev. méd. Chile]]></source>
<year>2016</year>
<volume>144</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>169-74</page-range></nlm-citation>
</ref>
<ref id="B20">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Carcinoma oral de células escamosas: Reporte de caso y revisión de literatura]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Boza]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
</person-group>
<source><![CDATA[Odovtos- Int J Dent Sc]]></source>
<year>2016</year>
<volume>18</volume>
<numero>1.1</numero>
<issue>1.1</issue>
<page-range>61-7</page-range></nlm-citation>
</ref>
<ref id="B21">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Understanding the biology of oral cancer]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Das]]></surname>
<given-names><![CDATA[B. R.]]></given-names>
</name>
<name>
<surname><![CDATA[Nagpal]]></surname>
<given-names><![CDATA[J. K]]></given-names>
</name>
</person-group>
<source><![CDATA[Med Sci Monit]]></source>
<year>2002</year>
<volume>8</volume>
<page-range>258-67</page-range></nlm-citation>
</ref>
<ref id="B22">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Carcinoma of the oral cavity. An analysis of 478 cases]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hirata]]></surname>
<given-names><![CDATA[RM]]></given-names>
</name>
<name>
<surname><![CDATA[Jaques]]></surname>
<given-names><![CDATA[D. A.]]></given-names>
</name>
<name>
<surname><![CDATA[Chambers]]></surname>
<given-names><![CDATA[R. G.]]></given-names>
</name>
<name>
<surname><![CDATA[Tuttle]]></surname>
<given-names><![CDATA[J. R.]]></given-names>
</name>
<name>
<surname><![CDATA[Mahoney]]></surname>
<given-names><![CDATA[W. D]]></given-names>
</name>
</person-group>
<source><![CDATA[Ann Surg.]]></source>
<year>1975</year>
<volume>182</volume>
<page-range>98-103</page-range></nlm-citation>
</ref>
<ref id="B23">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Squamous cell carcinoma of the head and neck in never smokernever drinkers: a descriptive epidemiologic study]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Dahlstrom]]></surname>
<given-names><![CDATA[K. R.]]></given-names>
</name>
<name>
<surname><![CDATA[Little]]></surname>
<given-names><![CDATA[J. A.]]></given-names>
</name>
<name>
<surname><![CDATA[Zafereo]]></surname>
<given-names><![CDATA[M. E.]]></given-names>
</name>
<name>
<surname><![CDATA[Lung]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Wei]]></surname>
<given-names><![CDATA[Q.]]></given-names>
</name>
<name>
<surname><![CDATA[Sturgis]]></surname>
<given-names><![CDATA[E. M]]></given-names>
</name>
</person-group>
<source><![CDATA[Head Neck]]></source>
<year>2008</year>
<volume>30</volume>
<page-range>75-84</page-range></nlm-citation>
</ref>
<ref id="B24">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Epidemiological study of malignant tumors in the oral and maxillofacial region: survey of member institutions of the Japanese Society ofOral and Maxillofacial Surgeons, 2002]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ariyoshi]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
<name>
<surname><![CDATA[Shimahara]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Omura]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
<name>
<surname><![CDATA[Yamamoto]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[Mizuki]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
<name>
<surname><![CDATA[Chiba]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
</person-group>
<source><![CDATA[2002]]></source>
<year>2008</year>
<volume>13</volume>
<page-range>220-8</page-range></nlm-citation>
</ref>
<ref id="B25">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Meta-analysis on clinicopathologic risk factors of leukoplakias undergoing malignant transformation]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Narayan]]></surname>
<given-names><![CDATA[T. V.]]></given-names>
</name>
<name>
<surname><![CDATA[Shilpashree]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<source><![CDATA[Journal of Oral and Maxillofacial Pathology: JOMFP]]></source>
<year>2016</year>
<volume>20</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>354-61</page-range></nlm-citation>
</ref>
<ref id="B26">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Displasia epitelial: Concepto y significación]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Aguirre Echebarria]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[Aguirre Urizar]]></surname>
<given-names><![CDATA[J.M.]]></given-names>
</name>
</person-group>
<source><![CDATA[Av Odontoestomatol]]></source>
<year>2008</year>
<volume>24</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>81-8</page-range></nlm-citation>
</ref>
<ref id="B27">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Malignant transformation of oral potentially malignant disorders in males: a retrospective cohort study]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ho]]></surname>
<given-names><![CDATA[P-S.]]></given-names>
</name>
<name>
<surname><![CDATA[Chen]]></surname>
<given-names><![CDATA[P-L.]]></given-names>
</name>
<name>
<surname><![CDATA[Warnakulasuriya]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Shieh]]></surname>
<given-names><![CDATA[T-Y.]]></given-names>
</name>
<name>
<surname><![CDATA[Chen]]></surname>
<given-names><![CDATA[Y-K.]]></given-names>
</name>
<name>
<surname><![CDATA[Huang]]></surname>
<given-names><![CDATA[I-Y]]></given-names>
</name>
</person-group>
<source><![CDATA[BMC Cancer]]></source>
<year>2009</year>
<volume>9</volume>
<page-range>260</page-range></nlm-citation>
</ref>
<ref id="B28">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Malignant transformation of oral leukoplakia in a welldefined cohort of 144 patients]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Brouns]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[Baart]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Karagozoglu]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
<name>
<surname><![CDATA[Aartman]]></surname>
<given-names><![CDATA[I.]]></given-names>
</name>
<name>
<surname><![CDATA[Bloemena]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[van der Waal]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
</person-group>
<source><![CDATA[Oral Dis]]></source>
<year>2014</year>
<volume>20</volume>
<page-range>19-24</page-range></nlm-citation>
</ref>
<ref id="B29">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Oral potentially malignant disorders: is malignant transformation predictable and preventable?]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Van der Waal]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
</person-group>
<source><![CDATA[Med Oral Pathol Oral Cir Bucal]]></source>
<year>2014</year>
<volume>19</volume>
<page-range>386-90</page-range></nlm-citation>
</ref>
<ref id="B30">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Gradación histopatológica de la malignidad y pronóstico del cáncer de cabeza y cuello]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ortega]]></surname>
<given-names><![CDATA[F. E.]]></given-names>
</name>
<name>
<surname><![CDATA[González]]></surname>
<given-names><![CDATA[M. A.]]></given-names>
</name>
<name>
<surname><![CDATA[Ruiz]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
</person-group>
<source><![CDATA[Med Oral]]></source>
<year>1998</year>
<volume>3</volume>
<page-range>148-62</page-range></nlm-citation>
</ref>
<ref id="B31">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Fatores prognósticos de câncer bucal]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Carvalho]]></surname>
<given-names><![CDATA[F. C. R.]]></given-names>
</name>
<name>
<surname><![CDATA[Dias]]></surname>
<given-names><![CDATA[E. P.]]></given-names>
</name>
<name>
<surname><![CDATA[Cabral]]></surname>
<given-names><![CDATA[M. G]]></given-names>
</name>
</person-group>
<source><![CDATA[RBO]]></source>
<year>2003</year>
<volume>60</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>21-3</page-range></nlm-citation>
</ref>
<ref id="B32">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA["Oral cancer.]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kademani]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<source><![CDATA[Mayo Clin Proc]]></source>
<year>2007</year>
<volume>82</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>878-87</page-range></nlm-citation>
</ref>
<ref id="B33">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Evaluation of oral cancer screening]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Burzynski]]></surname>
<given-names><![CDATA[N. J.]]></given-names>
</name>
<name>
<surname><![CDATA[Firriolo]]></surname>
<given-names><![CDATA[F. J.]]></given-names>
</name>
<name>
<surname><![CDATA[Butters]]></surname>
<given-names><![CDATA[J. V.]]></given-names>
</name>
<name>
<surname><![CDATA[Sorrel]]></surname>
<given-names><![CDATA[C. L]]></given-names>
</name>
</person-group>
<source><![CDATA[J Cancer Educ]]></source>
<year>1997</year>
<volume>12</volume>
<page-range>95-7</page-range></nlm-citation>
</ref>
<ref id="B34">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Early findings from community-based, clusterrandomized, controlled oral cancer screening trial in Kerala, India]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sankaranarayanan]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Mathew]]></surname>
<given-names><![CDATA[B.]]></given-names>
</name>
<name>
<surname><![CDATA[Jacob]]></surname>
<given-names><![CDATA[B. J.]]></given-names>
</name>
</person-group>
<source><![CDATA[Cancer]]></source>
<year>2000</year>
<volume>88</volume>
<page-range>664-73</page-range></nlm-citation>
</ref>
<ref id="B35">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Cáncer bucal: conocimiento básico de la población en Costa Rica]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Howard]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Castillo]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<source><![CDATA[Odovtos]]></source>
<year>2004</year>
<volume>6</volume>
<page-range>94-102</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
