<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1659-0775</journal-id>
<journal-title><![CDATA[Odontología Vital]]></journal-title>
<abbrev-journal-title><![CDATA[Odontología Vital]]></abbrev-journal-title>
<issn>1659-0775</issn>
<publisher>
<publisher-name><![CDATA[Universidad Latina de Costa Rica, Facultad de Odontología]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1659-07752018000200019</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Osteonecrosis mandibular relacionada con medicamentos: conceptos teóricos y prácticos actuales para el odontólogo general]]></article-title>
<article-title xml:lang="en"><![CDATA[Medication-related osteonecrosis of the jaw: current theoretical and useful concepts for the general practitioner]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fernández M]]></surname>
<given-names><![CDATA[Enrique]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Padilla A]]></surname>
<given-names><![CDATA[Paula]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Reyes]]></surname>
<given-names><![CDATA[Christopher]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Lisboa]]></surname>
<given-names><![CDATA[David]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad San Sebastián  ]]></institution>
<addr-line><![CDATA[ Santiago de Chile]]></addr-line>
<country>Chile</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad San Sebastián  ]]></institution>
<addr-line><![CDATA[ Santiago de Chile]]></addr-line>
<country>Chile</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad San Sebastián  ]]></institution>
<addr-line><![CDATA[ Santiago de Chile]]></addr-line>
<country>Chile</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Hospital de Angol  ]]></institution>
<addr-line><![CDATA[ IX Región]]></addr-line>
<country>Chile</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2018</year>
</pub-date>
<numero>29</numero>
<fpage>19</fpage>
<lpage>32</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_arttext&amp;pid=S1659-07752018000200019&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_abstract&amp;pid=S1659-07752018000200019&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_pdf&amp;pid=S1659-07752018000200019&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La osteonecrosis mandibular relacionada con medicamentos (ONMRM), es un síndrome asociado al uso de fármacos antirresortivos (bifosfonatos), inhibidores de ligando RANK-L y de angiogénesis, administrados para el tratamiento de enfermedades como cáncer y osteoporosis. Objetivos: actualizar contenidos respecto a etiopatogenia y tratamientos de ONMRM, enfatizando el rol del factor &#8220;infección&#8221;, y en la perspectiva de que el tratamiento, pueda ser implementado por el odontólogo general. Materiales y métodos: se realiza un scoping review mediante acceso a las bases de datos MEDLINE (Pubmed) y Cochrane library, de artículos publicados desde el año 2010 en adelante, en inglés y castellano, empleando palabras claves incluidas en los medical subject headings (MeSH). Conclusiones: La evidencia recogida demuestra que, teniendo en cuenta los factores de riesgo individuales, no existen en general contraindicaciones para llevar a cabo exodoncias, bajo específicos protocolos quirúrgicos, en pacientes con terapias antiresortivas o antiangiogénicas, ya que al parecer, el origen de la ONMRM se asocia a contaminación por biofilm, más que al uso o efecto de estos fármacos. En el caso del tratamiento de una ONMRM ya instalada, las terapias quirúrgicas resultan ser más eficaces que las paliativas en la remisión del cuadro.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Medication-related osteonecrosis of the jaw (MRONJ) is a syndrome associated to the use of antiresorptive therapy (bisphosphonates), RANK-ligand inhibitors and angiogenesis inhibitors drugs, used for the treatment of cancer and osteoporosis among other diseases. Purpose: Update the knowledge on its etiopathogenesis emphasizing the role of infection, and in doing so, look for treatments that can be carried out by general practitioners. Materials and methods: A scoping review is performed through Medline (Pubmed) and Cochrane databases, of articles published from to 2010, in English and Spanish, including MeSH keywords such as &#8220;osteonecrosis of the jaw; &#8220;antiresorptive drug&#8221;; &#8220;bisphosphonates&#8221;; &#8220;Denosumab&#8221;; &#8220;surgical wound infection&#8221;; &#8220;dental extraction&#8221;. Conclusions: The current evidence demonstrate that, taking into account individual risk factors, teeth extractions can be harmless performed in patients under antiresorptive or antiangiogenic interetherapies because the origin of MRONJ appears to be more related to biofilm contamination than with the use or effects of any specific drug. Once MRONJ is installed, surgical therapies prove to be more effective in the treatment and remission of these lesions.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Osteonecrosis mandibular]]></kwd>
<kwd lng="es"><![CDATA[medicamentos antirresortivos, bifosfonatos]]></kwd>
<kwd lng="es"><![CDATA[denosumab]]></kwd>
<kwd lng="es"><![CDATA[infección herida quirúrgica]]></kwd>
<kwd lng="es"><![CDATA[extracción dental]]></kwd>
<kwd lng="en"><![CDATA[Osteonecrosis of the jaw]]></kwd>
<kwd lng="en"><![CDATA[antiresorptive drug]]></kwd>
<kwd lng="en"><![CDATA[bisphosphonates]]></kwd>
<kwd lng="en"><![CDATA[Denosumab]]></kwd>
<kwd lng="en"><![CDATA[surgical wound infection]]></kwd>
<kwd lng="en"><![CDATA[dental extraction]]></kwd>
</kwd-group>
</article-meta>
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