<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1659-0201</journal-id>
<journal-title><![CDATA[Población y Salud en Mesoamérica]]></journal-title>
<abbrev-journal-title><![CDATA[PSM]]></abbrev-journal-title>
<issn>1659-0201</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Costa Rica. Centro Centroamericano de Población]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1659-02012022000100465</article-id>
<article-id pub-id-type="doi">10.15517/psm.v0i19.48038</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[La depresión mayor en Costa Rica: aspectos epidemiológicos y psicobiológicos]]></article-title>
<article-title xml:lang="en"><![CDATA[Major depression disorder in Costa Rica: epidemiological and neurobiological aspects]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sequeira-Cordero]]></surname>
<given-names><![CDATA[Andrey]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Blanco-Vargas]]></surname>
<given-names><![CDATA[Marilyn]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Brenes]]></surname>
<given-names><![CDATA[Juan Carlos]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Costa Rica  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Costa Rica</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Costa Rica  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Costa Rica</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad de Costa Rica  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Costa Rica</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2022</year>
</pub-date>
<volume>19</volume>
<numero>2</numero>
<fpage>465</fpage>
<lpage>489</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_arttext&amp;pid=S1659-02012022000100465&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_abstract&amp;pid=S1659-02012022000100465&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_pdf&amp;pid=S1659-02012022000100465&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen Introducción: la depresión mayor es uno de los trastornos mentales más comunes y una de las principales causas de discapacidad en el mundo, con una prevalencia que ha aumentado en las últimas décadas. El objetivo de este ensayo es presentar datos epidemiológicos, así como revisar brevemente los mecanismos psicobiológicos de la depresión relacionados con el estrés crónico. Finalmente, discutiremos algunas estrategias para prevenirla y/o tratarla. Proposición: ciertos tratamientos alternativos complementarios a la medicación y psicoterapia podrían ser mucho más eficaces para evitar y mitigar los efectos del estrés crónico y el riesgo de padecer depresión. Argumentos para la discusión: el estrés crónico puede precipitar un episodio depresivo debido a la hiperactividad de la amígdala y del eje hipotalámico-hipofisario-suprarrenal (HHS), la falla en los mecanismos de retrocontrol negativo del HHS, la depleción de monoaminas, la disminución en los niveles de neurotrofinas, el aumento en la excitotoxicidad glutamatérgica, la reducción en la neurogénesis hipocampal, la disfunción de la corteza prefrontal y una respuesta inflamatoria excesiva. Conclusiones: la acumulación crónica de estresores psicosociales sobre los que se tiene poco control, más el sedentarismo, una mala alimentación y pocos espacios de esparcimiento le confieren a nuestro estilo de vida actual un alto potencial depresogénico. Actividades que incluyan ejercicio, interacciones sociales significativas, actividades recreativas, exposición a ambientes naturales, una dieta balanceada y rutinas saludables representarían una estrategia altamente eficaz para el manejo de la depresión y el mejoramiento de la salud integral.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Introduction: Major depression is one of the most common mental illnesses and one of the principal causes of disability worldwide, with an increasing prevalence in recent decades. The aim of this essay is to present epidemiological data, as well as to briefly review the psychobiological mechanisms of depression related to the exposure to chronic stress. Finally, we will also discuss some strategies for the prevention and/or treatment of the disease. Proposal: Alternative treatments complementing medication and psychotherapy could be much more effective in preventing and mitigating the effects of chronic stress and the risk of depression than these treatments alone. Arguments for discussion: Chronic stress can precipitate a depressive episode due to hyperactivity of the amygdala and hypothalamic-pituitary-adrenal (HPA) axis, failure of the HPA negative feedback, monoamine depletion, decreased levels of neurotrophins, increased glutamatergic excitotoxicity, reduced hippocampal neurogenesis, prefrontal cortex dysfunction, and excessive inflammatory response. Conclusions:The chronic accumulation of uncontrollable psychosocial stressors plus a sedentary lifestyle, a poor diet, and limited time or places for recreational activities underlie the high depresogenic potential of our current lifestyles. In contrast, activities that include exercise, meaningful social interactions, recreational activities, exposure to natural environments, a balanced diet, and healthy routines would represent a highly effective strategy for managing depression and improving overall health.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[depresión]]></kwd>
<kwd lng="es"><![CDATA[prevalencia]]></kwd>
<kwd lng="es"><![CDATA[factores psicobiológicos]]></kwd>
<kwd lng="es"><![CDATA[enriquecimiento ambiental]]></kwd>
<kwd lng="en"><![CDATA[Depression]]></kwd>
<kwd lng="en"><![CDATA[prevalence]]></kwd>
<kwd lng="en"><![CDATA[psychobiologic factors]]></kwd>
<kwd lng="en"><![CDATA[environmental enrichment]]></kwd>
</kwd-group>
</article-meta>
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