1409-4142 1409-4142 S1409-41422018000300004 Costa Rica Honduras Nicaragua 00 12 2018 00 12 2018 20 4 10 1 2015 17 1-2 1-2 2 Biomarkers Definitions Working Group 2011 69 89-95 3 2017 135 e1054-91 4 2017 70 6 6 776-803 5 2015 131 54-61 6 2012 380 1387-95 7 2017 19 D D D102-12 8 2013 62 e147-239 9 2015 443 29-38 10 2004 43 61-7 11 2004 147 331-8 12 2015 3 40-9 13 2011 17 181-7 14 2010 165 83-92 15 2012 380 756-66 16 2013 113 725-38 17 201 14 14 4 18 2017 10 19 2005 26 2269-76 20 2006 27 330-7 21 2018 14 27-39