<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1409-2433</journal-id>
<journal-title><![CDATA[Revista de Matemática Teoría y Aplicaciones]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Mat]]></abbrev-journal-title>
<issn>1409-2433</issn>
<publisher>
<publisher-name><![CDATA[Centro de Investigaciones en Matemática Pura y Aplicada (CIMPA) y Escuela de Matemática, San José, Costa Rica.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1409-24332014000200004</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Modelo matemático del transporte de una toxina en una red trófica marina]]></article-title>
<article-title xml:lang="en"><![CDATA[Mathematical model for toxin transport in a marine food chain]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Arbelaez A.]]></surname>
<given-names><![CDATA[Daniel]]></given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ruiz V.]]></surname>
<given-names><![CDATA[Jorge Mauricio]]></given-names>
</name>
</contrib>
</contrib-group>
<aff id="A01">
<institution><![CDATA[,Universidad Nacional de Colombia Departamento de Matemáticas ]]></institution>
<addr-line><![CDATA[ Bogotá D.C.]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="A02">
<institution><![CDATA[,Universidad Nacional de Colombia Departamento de Matemáticas ]]></institution>
<addr-line><![CDATA[ Bogotá D.C.]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2014</year>
</pub-date>
<volume>21</volume>
<numero>2</numero>
<fpage>227</fpage>
<lpage>247</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_arttext&amp;pid=S1409-24332014000200004&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_abstract&amp;pid=S1409-24332014000200004&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_pdf&amp;pid=S1409-24332014000200004&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Algunos casos de intoxicación por consumo de peces contaminados, como la intoxicación por ciguatera, ocurren inesperadamente y no son fáciles de detectar previamente, dado que los peces que portan la toxina no presentan aspecto y/o síntomas de enfermos. En este trabajo proponemos un modelo matemático para el transporte y acumulación de una toxina a través de una cadena alimentaria. El modelo se plantea mediante un sistema rígido de ecuaciones diferenciales que describen la dinámica. Se analiza la estabilidad local de la solución de equilibrio. Se discuten diferentes escenarios de aparición de brotes de una toxina a partir de simulaciones numéricas obtenidas mediante un esquema de discretización que combina un método de Runge-Kutta de tercer orden y la regla del trapecio, evitando la rigidez del sistema. Los resultados muestran que el tiempo que tarda en desaparecer la toxina en la red trófica depende del estado en que se encuentra la dinámica poblacional al momento del brote. Esta información puede emplearse para establecer un tiempo de veda en la pesca de tal manera que la toxina se reduzca a niveles inocuos para la salud humana.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Some cases of poisoning by consumption of contaminated fish, like the Ciguatera poisoning, occur unexpectedly and they are not easy to detect previously since the fish that carry the toxin do not have appearance and/or symptoms of illness. In this paper a mathematical model for transport and acumulation of a toxin through a food chain is proposed. The model is a stiff system of ordinary differential equations that describes the dynamic. We propose a numerical scheme that combines a third-order Runge-Kutta method and trapezoidal rule to avoid the stiffness of the system. Several scenarios of toxin outbreaks are simulated; the results show that the time it takes to the toxin disappear in the trophic chain, depends on the state of the dynamics population at the time of the outbreak. This information can be used to set a ban on fishing until the toxin be reduced to harmless levels for the human health.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[cadena trófica]]></kwd>
<kwd lng="es"><![CDATA[modelación matemática]]></kwd>
<kwd lng="es"><![CDATA[transporte de biotoxinas]]></kwd>
<kwd lng="es"><![CDATA[ecuaciones diferenciales rígidas]]></kwd>
<kwd lng="en"><![CDATA[food chain]]></kwd>
<kwd lng="en"><![CDATA[mathematical modeling]]></kwd>
<kwd lng="en"><![CDATA[biotoxin transport]]></kwd>
<kwd lng="en"><![CDATA[stiff differential equations]]></kwd>
</kwd-group>
</article-meta>
</front><body><![CDATA[ <div style="text-align: justify;">     <div style="text-align: center;"><font  style="font-family: verdana; font-weight: bold;" size="4">Modelo matem&aacute;tico del transporte de una toxina en una red tr&oacute;fica marina</font>    <br>     <br> <font style="font-family: verdana; font-weight: bold;" size="4">Mathematical model for toxin transport in a marine food chain</font>    <br> </div>     <br>     <div style="text-align: center;"><font style="font-family: verdana;"  size="2">Daniel Arbelaez A.<a href="#1">*</a><a name="3"></a>+ Jorge Mauricio Ruiz V. <a href="#2">&#8224;</a><a name="4"></a>*</font>    <br> </div> <font style="font-family: verdana;" size="2">    <br> </font> <hr style="width: 100%; height: 2px;">    <br> <font style="font-family: verdana; font-weight: bold;" size="3">Resumen</font>    ]]></body>
<body><![CDATA[<br>     <br> <font style="font-family: verdana;" size="2">Algunos casos de intoxicaci&oacute;n por consumo de peces contaminados, como la intoxicaci&oacute;n por ciguatera, ocurren inesperadamente y no son f&aacute;ciles de detectar previamente, dado que los peces que portan la toxina no presentan aspecto y/o s&iacute;ntomas de enfermos. En este trabajo proponemos un modelo matem&aacute;tico para el transporte y acumulaci&oacute;n de una toxina a trav&eacute;s de una cadena alimentaria. El modelo se plantea mediante un sistema r&iacute;gido de ecuaciones diferenciales que describen la din&aacute;mica. Se analiza la estabilidad local de la soluci&oacute;n de equilibrio. Se discuten diferentes escenarios de aparici&oacute;n de brotes de una toxina a partir de simulaciones num&eacute;ricas obtenidas mediante un esquema de discretizaci&oacute;n que combina un m&eacute;todo de Runge-Kutta de tercer orden y la regla del trapecio, evitando la rigidez del sistema. Los resultados muestran que el tiempo que tarda en desaparecer la toxina en la red tr&oacute;fica depende del estado en que se encuentra la din&aacute;mica poblacional al momento del brote. Esta informaci&oacute;n puede emplearse para establecer un tiempo de veda en la pesca de tal manera que la toxina se reduzca a niveles inocuos para la salud humana. </font>    <br>     <br> <font style="font-family: verdana;" size="2"><span  style="font-weight: bold;">Palabras clave:</span> cadena tr&oacute;fica; modelaci&oacute;n matem&aacute;tica; transporte de biotoxinas; ecuaciones diferenciales r&iacute;gidas.</font>    <br>     <br> <font style="font-family: verdana; font-weight: bold;" size="3">Abstract</font>    <br>     <br> <font style="font-family: verdana;" size="2">Some cases of poisoning by consumption of contaminated fish, like the Ciguatera poisoning, occur unexpectedly and they are not easy to detect previously since the fish that carry the toxin do not have appearance and/or symptoms of illness. In this paper a mathematical model for transport and acumulation of a toxin through a food chain is proposed. The model is a stiff system of ordinary differential equations that describes the dynamic. We propose a numerical scheme that combines a third-order Runge-Kutta method and trapezoidal rule to avoid the stiffness of the system. Several scenarios of toxin outbreaks are simulated; the results show that the time it takes to the toxin disappear in the trophic chain, depends on the state of the dynamics population at the time of the outbreak. This information can be used to set a ban on fishing until the toxin be reduced to harmless levels for the human health. </font>    <br>     <br> <font style="font-family: verdana;" size="2"><span  style="font-weight: bold;">Keywords:</span> food chain; mathematical modeling; biotoxin transport; stiff differential equations.</font>    ]]></body>
<body><![CDATA[<br>     <br> <font style="font-family: verdana;" size="2">Mathematics Subject Classification: 92D25, 93A30, 37N25, 65L04.    <br>     <br> </font> <hr style="width: 100%; height: 2px;">    <br> <font style="font-family: verdana;" size="2">Ver contenido disponible en pdf    <br>     <br> </font> <hr style="width: 100%; height: 2px;">    <br> <font style="font-family: verdana; font-weight: bold;" size="3">Referencias</font>    <br>     <br>     ]]></body>
<body><![CDATA[<!-- ref --><div style="text-align: left;"><font style="font-family: verdana;"  size="2">[1] Arencibia, G.; Mancera, J.E.; Delgado, G. (2010) <span style="font-style: italic;">La ciguatera, un riesgo potencial para la salud humana: preguntas frecuentes</span>, Universidad Nacional de Colombia, San Andr&eacute;s Isla, Colombia.    &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=1963592&pid=S1409-2433201400020000400001&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --></font>    <br>     <!-- ref --><br> <font style="font-family: verdana;" size="2">[2] Barton, E.D.; Tanner, P.; Turchen, S.G.; Manoguerra. A. (1995) &#8220;Ciguatera fish poisoning. A Southern California epidemic", <span  style="font-style: italic;">Western Journal of Medicine</span> <span style="font-weight: bold;">163</span>(1): 31&#8211;35.    &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=1963595&pid=S1409-2433201400020000400002&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --></font>    <br>     <!-- ref --><br> <font style="font-family: verdana;" size="2">[3] Chattopadhyay, J.; Arino, O. (1999) &#8220;A predator-prey model with disease in the prey", <span style="font-style: italic;">Nonlinear Analysis: Theory, Methods &amp; Applications</span> <span style="font-weight: bold;">36</span>: 747&#8211; 766.    &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=1963598&pid=S1409-2433201400020000400003&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --></font>    <br>     <!-- ref --><br> <font style="font-family: verdana;" size="2">[4] Chattopadhyay, J.; Sarkar, R.R. (2003) &#8220;Chaos to order: preliminary experiments with a population dynamics models of three trophic levels", <span style="font-style: italic;">Ecological</span></font><br  style="font-style: italic;"> <font style="font-family: verdana;" size="2"><span  style="font-style: italic;">Modelling</span> <span  style="font-weight: bold;">163</span>(1-2): 45&#8211;50.    &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=1963601&pid=S1409-2433201400020000400004&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --></font>    <br>     <!-- ref --><br> <font style="font-family: verdana;" size="2">[5] Chattopadhyay, J.; Sarkar, R.R.; Pal, S. (2004) &#8220;Mathematical modeling of harmful algal blooms supported by experimental findings", <span style="font-style: italic;">Ecological</span></font><br  style="font-style: italic;"> <font style="font-family: verdana;" size="2"><span  style="font-style: italic;">Complexity</span> <span  style="font-weight: bold;">1</span>(3): 225&#8211;235.    &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=1963604&pid=S1409-2433201400020000400005&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --></font>    <br>     <!-- ref --><br> <font style="font-family: verdana;" size="2">6 De Sylva, D.P. (1994) &#8220; Distribution and ecology of ciguatera fish poisoning in Florida, with emphasis on the Florida Keys", <span  style="font-style: italic;">Bulletin of Marine Science</span></font><font style="font-family: verdana;" size="2"><span  style="font-weight: bold;"> 54</span>(3): 944&#8211;954.    &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=1963607&pid=S1409-2433201400020000400006&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --></font>    <br>     <!-- ref --><br> <font style="font-family: verdana;" size="2">[7] de Fouw, J.C.; van Egmond, H.P.; Speijers, G.J.A. (2001) &#8220;Ciguatera fish poisoning: a review", RIVM report 388802021, Rijksinstituut voor Volksgezondheid en Milieu (National Institute of Public Health and Enviroment, The Netherlands), Bilthoven</font>    &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=1963610&pid=S1409-2433201400020000400007&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --><br>     ]]></body>
<body><![CDATA[<!-- ref --><br> <font style="font-family: verdana;" size="2">8 Egmond, H.P. van; Apeldoorn, M.E. van; Speijers, G.J.A. (2005) <span style="font-style: italic;">Biotoxinas Marinas</span>. Estudio FAO: Alimentaci&oacute;n y Nutrici&oacute;n, Organizaci&oacute;n de las</font><font  style="font-family: verdana;" size="2"> Naciones Unidas para la Agricultura y la Alimentaci&oacute;n (FAO), Roma.    &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=1963612&pid=S1409-2433201400020000400008&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --></font>    <br>     <!-- ref --><br> <font style="font-family: verdana;" size="2">9 Holling, C.S. (1965) &#8220;The functional response of predator to prey density and its role in mimicry and population regulation", <span  style="font-style: italic;">Mem. Entoml</span>. Soc. Can</font><font style="font-family: verdana;"  size="2"><span style="font-weight: bold;"> 97</span>(S45): 5-60.    &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=1963615&pid=S1409-2433201400020000400009&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --></font>    <br>     <!-- ref --><br> <font style="font-family: verdana;" size="2">[10] Lech, J.J.; Vodicnik, M.J.; Elcombe, C.R. (1982) &#8220;Induction of monooxygenase activity in fish"; <span style="font-style: italic;">Aquatic Toxicology</span> <span style="font-weight: bold;">1</span>(107): 415&#8211;418.    &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=1963618&pid=S1409-2433201400020000400010&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --></font>    <br>     <!-- ref --><br> <font style="font-family: verdana;" size="2">11 Kooi, B.W.; Bontje, D.; Voorn, G.A.K. van; Kooijman, S.A.L.M. (2008) &#8220;Sublethal toxic efects in a simple aquatic food chain", <span style="font-style: italic;">Ecological Modelling</span></font><font  style="font-family: verdana;" size="2"><span style="font-weight: bold;"> 212</span>(3-4): 304&#8211;318.    &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=1963621&pid=S1409-2433201400020000400011&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --></font>    <br>     <!-- ref --><br> <font style="font-family: verdana;" size="2">[12] Kubanek, J.; Hicks, M.K.; Naar, J.; Villareal, T.A. (2005) &#8220;Does the red tide dinoflagellate Karenia brevis use allelopathy to outcompete other phytoplankton?", <span style="font-style: italic;">Limnology and Oceanography</span> <span style="font-weight: bold;">50</span>(3): 883&#8211;895.    &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=1963624&pid=S1409-2433201400020000400012&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --></font>    <br>     <!-- ref --><br> <font style="font-family: verdana;" size="2">[13] Lehane, L.; Lewis, R.J. (2000) &#8220;Ciguatera: recent advances but the risk remains", <span style="font-style: italic;">International Journal of Food Microbiology</span> <span style="font-weight: bold;">61</span>(2-3): 91&#8211;125.    &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=1963627&pid=S1409-2433201400020000400013&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --></font>    <br>     <!-- ref --><br> <font style="font-family: verdana;" size="2">[14] Lewis, R.J.; Holmes, M.J. (1993) &#8220;Origin and transfer of toxins involved in ciguatera", <span style="font-style: italic;">Comp. Biochem. Physiol. C: Pharmacology, Toxicology and Endocrinology</span> <span style="font-weight: bold;">106</span>(3): 615&#8211;628.    &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=1963630&pid=S1409-2433201400020000400014&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --></font>    ]]></body>
<body><![CDATA[<br>     <!-- ref --><br> <font style="font-family: verdana;" size="2">[15] Lewis, R.J. (2001) &#8220;The changing face of ciguatera", <span style="font-style: italic;">Toxicon</span> <span style="font-weight: bold;">39</span>(1): 97-106.    &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=1963633&pid=S1409-2433201400020000400015&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --></font>    <br>     <!-- ref --><br> <font style="font-family: verdana;" size="2">[16] Masayuki, I.; Keisuke,M.; Hisatoshi,U.;Megumi M.; Masahiro, H. (2004) &#8220;First- and second-generation total synthesis of ciguatoxin CTX3C", <span style="font-style: italic;">Proceedings of the National Academy of Sciences of the United States of America</span> <span style="font-weight: bold;">101</span>(33): 12013&#8211;12018.    &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=1963636&pid=S1409-2433201400020000400016&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --></font>    <br>     <!-- ref --><br> <font style="font-family: verdana;" size="2">17 Parson, M.L.; Settlemier, C.J.; Bienfang, P.K. (2010) &#8220;A simple model capable of simulating the population dynamics of Gambierdiscus, the benthic</font><font style="font-family: verdana;" size="2"> dinoagellate responsible for ciguatera fish poisoning", <span style="font-style: italic;">Harmful Algae</span> <span style="font-weight: bold;">10</span>(1): 71&#8211;80.    &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=1963639&pid=S1409-2433201400020000400017&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --></font>    <br>     ]]></body>
<body><![CDATA[<!-- ref --><br> <font style="font-family: verdana;" size="2">[18] Pielou, E.C. (1969) <span style="font-style: italic;">An Introduction to Mathematical Ecology</span>. Wiley- Interscience, New York.    &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=1963642&pid=S1409-2433201400020000400018&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --></font>    <br>     <!-- ref --><br> <font style="font-family: verdana;" size="2">19 Ruff, T.A.; Lewis, R.J. (1994) &#8220;Clinical aspects of ciguatera: an overview", Memoirs of the Queensland Museum - <span  style="font-style: italic;">Nature</span>34(3): 609&#8211;619.    &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=1963645&pid=S1409-2433201400020000400019&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --></font>    <br>     <!-- ref --><br> <font style="font-family: verdana;" size="2">[20] Sakamoto, B.; Nagai, H.; Hokama, Y. (1996). &#8220;Stimulators of Gambierdiscus toxicus (Dinophycease) growth: the possible role of gambieric acid-A as an endogenous growth enhancer", <span  style="font-style: italic;">Phycologia</span> <span  style="font-weight: bold;">35</span>(4): 350&#8211;353.    &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=1963648&pid=S1409-2433201400020000400020&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --></font>    <br>     <!-- ref --><br> <font style="font-family: verdana;" size="2">[21] Sarkar, R.R.; Pal, S.; Chattopadhyay, J. (2005) &#8220;Role of two toxinproducing plankton and their efect on phytoplankton system&#8211; Amathematical study supported by experimental findings", <span  style="font-style: italic;">BioSystems</span> <span style="font-weight: bold;">80</span>(1): 11&#8211;23.    &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=1963651&pid=S1409-2433201400020000400021&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --></font>    <br> </div> <font style="font-family: verdana;" size="2">    <br> </font><font style="font-family: verdana;" size="2"><a name="1"></a><a  href="#3">*</a> Departamento de Matem&aacute;ticas, Universidad Nacional de Colombia, Bogot&aacute; D.C., Colombia. E-Mail: darbelaeza@unal.edu.co</font>    <br>     <br> <font style="font-family: verdana;" size="2"><a name="2"></a><a  href="#4">&#8224; </a>Departamento de Matem&aacute;ticas, Universidad Nacional de Colombia, Bogot&aacute; D.C., Colombia. E-Mail: jmruizv@unal.edu.co</font><font  style="font-family: verdana;" size="2">    <br> </font> <hr style="width: 100%; height: 2px;">     <div style="text-align: center;"><font style="font-family: verdana;"  size="2"><span style="font-weight: bold;">Received: 9/Sep/2013; Revised: 4/Jun/2014; Accepted: 12/Jun/2014</span></font></div> </div>      ]]></body><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Arencibia]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
<name>
<surname><![CDATA[Mancera]]></surname>
<given-names><![CDATA[J.E.]]></given-names>
</name>
<name>
<surname><![CDATA[Delgado]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
</person-group>
<source><![CDATA[La ciguatera, un riesgo potencial para la salud humana: preguntas frecuentes]]></source>
<year>2010</year>
<publisher-loc><![CDATA[San Andrés Isla ]]></publisher-loc>
<publisher-name><![CDATA[Universidad Nacional de Colombia]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Barton]]></surname>
<given-names><![CDATA[E.D.]]></given-names>
</name>
<name>
<surname><![CDATA[Tanner]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[Turchen]]></surname>
<given-names><![CDATA[S.G.]]></given-names>
</name>
<name>
<surname><![CDATA[Manoguerra.]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
</person-group>
<article-title xml:lang="en"><![CDATA[Ciguatera fish poisoning. A Southern California epidemic]]></article-title>
<source><![CDATA[Western Journal of Medicine]]></source>
<year>1995</year>
<volume>163</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>31-35</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chattopadhyay]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Arino]]></surname>
<given-names><![CDATA[O.]]></given-names>
</name>
</person-group>
<article-title xml:lang="en"><![CDATA[A predator-prey model with disease in the prey]]></article-title>
<source><![CDATA[Nonlinear Analysis: Theory, Methods & Applications]]></source>
<year>1999</year>
<volume>36</volume>
<page-range>747- 766</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chattopadhyay]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Sarkar]]></surname>
<given-names><![CDATA[R.R.]]></given-names>
</name>
</person-group>
<article-title xml:lang="en"><![CDATA[Chaos to order: preliminary experiments with a population dynamics models of three trophic levels]]></article-title>
<source><![CDATA[Ecological Modelling]]></source>
<year>2003</year>
<volume>163</volume>
<numero>1-2</numero>
<issue>1-2</issue>
<page-range>45-50</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chattopadhyay]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Sarkar]]></surname>
<given-names><![CDATA[R.R.]]></given-names>
</name>
<name>
<surname><![CDATA[Pal]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
</person-group>
<article-title xml:lang="en"><![CDATA[Mathematical modeling of harmful algal blooms supported by experimental findings]]></article-title>
<source><![CDATA[Ecological Complexity]]></source>
<year>2004</year>
<volume>1</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>225-235</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[De Sylva,]]></surname>
<given-names><![CDATA[D.P]]></given-names>
</name>
</person-group>
<article-title xml:lang="en"><![CDATA[Distribution and ecology of ciguatera fish poisoning in Florida, with emphasis on the Florida Keys]]></article-title>
<source><![CDATA[Bulletin of Marine Science]]></source>
<year>1994</year>
<volume>54</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>944–954</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[de Fouw]]></surname>
<given-names><![CDATA[J.C.]]></given-names>
</name>
<name>
<surname><![CDATA[van Egmond]]></surname>
<given-names><![CDATA[H.P.]]></given-names>
</name>
<name>
<surname><![CDATA[Speijers]]></surname>
<given-names><![CDATA[G.J.A.]]></given-names>
</name>
</person-group>
<source><![CDATA[Ciguatera fish poisoning: a review: RIVM report 388802021]]></source>
<year>2001</year>
<publisher-loc><![CDATA[Bilthoven ]]></publisher-loc>
<publisher-name><![CDATA[Rijksinstituut voor Volksgezondheid en MilieuNational Institute of Public Health and Enviroment, The Netherlands]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Egmond]]></surname>
<given-names><![CDATA[H.P]]></given-names>
</name>
<name>
<surname><![CDATA[Apeldoorn]]></surname>
<given-names><![CDATA[M.E]]></given-names>
</name>
<name>
<surname><![CDATA[Speijers]]></surname>
<given-names><![CDATA[G.J.A]]></given-names>
</name>
</person-group>
<source><![CDATA[Biotoxinas Marinas]]></source>
<year>2005</year>
<publisher-loc><![CDATA[Roma ]]></publisher-loc>
<publisher-name><![CDATA[Estudio FAO: Alimentación y Nutrición, Organización de las Naciones Unidas para la Agricultura y la Alimentación (FAO)]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Holling]]></surname>
<given-names><![CDATA[C.S]]></given-names>
</name>
</person-group>
<article-title xml:lang="en"><![CDATA[The functional response of predator to prey density and its role in mimicry and population regulation]]></article-title>
<source><![CDATA[Mem. Entoml. Soc. Can]]></source>
<year>1965</year>
<volume>97</volume>
<numero>45</numero>
<issue>45</issue>
<page-range>-60</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lech]]></surname>
<given-names><![CDATA[J.J.]]></given-names>
</name>
<name>
<surname><![CDATA[Vodicnik]]></surname>
<given-names><![CDATA[M.J.]]></given-names>
</name>
<name>
<surname><![CDATA[Elcombe]]></surname>
<given-names><![CDATA[C.R.]]></given-names>
</name>
</person-group>
<article-title xml:lang="en"><![CDATA[Induction of monooxygenase activity in fish]]></article-title>
<source><![CDATA[Aquatic Toxicology]]></source>
<year>1982</year>
<volume>1</volume>
<page-range>107</page-range><page-range>415-418</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kooi]]></surname>
<given-names><![CDATA[B.W]]></given-names>
</name>
<name>
<surname><![CDATA[Bontje]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Voorn]]></surname>
<given-names><![CDATA[G.A.K]]></given-names>
</name>
<name>
<surname><![CDATA[Kooijman]]></surname>
<given-names><![CDATA[S.A.L.M]]></given-names>
</name>
</person-group>
<article-title xml:lang="en"><![CDATA[Sublethal toxic efects in a simple aquatic food chain]]></article-title>
<source><![CDATA[Ecological Modelling]]></source>
<year>2008</year>
<volume>212</volume>
<page-range>3-4</page-range><page-range>304–318</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kubanek]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Hicks]]></surname>
<given-names><![CDATA[M.K.]]></given-names>
</name>
<name>
<surname><![CDATA[Naar]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Villareal]]></surname>
<given-names><![CDATA[T.A.]]></given-names>
</name>
</person-group>
<article-title xml:lang="en"><![CDATA[Does the red tide dinoflagellate Karenia brevis use allelopathy to outcompete other phytoplankton?]]></article-title>
<source><![CDATA[Limnology and Oceanography]]></source>
<year>2005</year>
<volume>50</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>883-895</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lehane]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[Lewis]]></surname>
<given-names><![CDATA[R.J.]]></given-names>
</name>
</person-group>
<article-title xml:lang="en"><![CDATA[Ciguatera: recent advances but the risk remains]]></article-title>
<source><![CDATA[International Journal of Food Microbiology]]></source>
<year>2000</year>
<volume>61</volume>
<numero>2-3</numero>
<issue>2-3</issue>
<page-range>91-125</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lewis]]></surname>
<given-names><![CDATA[R.J.]]></given-names>
</name>
<name>
<surname><![CDATA[Holmes]]></surname>
<given-names><![CDATA[M.J.]]></given-names>
</name>
</person-group>
<article-title xml:lang="en"><![CDATA[Origin and transfer of toxins involved in ciguatera]]></article-title>
<source><![CDATA[Comp. Biochem. Physiol. C: Pharmacology, Toxicology and Endocrinology]]></source>
<year>1993</year>
<volume>106</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>615-628</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lewis]]></surname>
<given-names><![CDATA[R.J.]]></given-names>
</name>
</person-group>
<article-title xml:lang="en"><![CDATA[The changing face of ciguatera]]></article-title>
<source><![CDATA[Toxicon]]></source>
<year>2001</year>
<volume>39</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>97-106</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Masayuki]]></surname>
<given-names><![CDATA[I.]]></given-names>
</name>
<name>
<surname><![CDATA[Keisuke]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Hisatoshi]]></surname>
<given-names><![CDATA[U.]]></given-names>
</name>
<name>
<surname><![CDATA[Megumi]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Masahiro]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
</person-group>
<article-title xml:lang="en"><![CDATA[First- and second-generation total synthesis of ciguatoxin CTX3C]]></article-title>
<source><![CDATA[Proceedings of the National Academy of Sciences of the United States of America]]></source>
<year>2004</year>
<volume>101</volume>
<numero>33</numero>
<issue>33</issue>
<page-range>12013-12018</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Parson]]></surname>
<given-names><![CDATA[M.L]]></given-names>
</name>
<name>
<surname><![CDATA[Settlemier]]></surname>
<given-names><![CDATA[C.J]]></given-names>
</name>
<name>
<surname><![CDATA[Bienfang]]></surname>
<given-names><![CDATA[P.K]]></given-names>
</name>
</person-group>
<article-title xml:lang="en"><![CDATA[A simple model capable of simulating the population dynamics of Gambierdiscus, the benthic dinoagellate responsible for ciguatera fish poisoning]]></article-title>
<source><![CDATA[Harmful Algae]]></source>
<year>2010</year>
<volume>10</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>71–80</page-range></nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pielou]]></surname>
<given-names><![CDATA[E.C.]]></given-names>
</name>
</person-group>
<source><![CDATA[An Introduction to Mathematical Ecology]]></source>
<year>1969</year>
<publisher-loc><![CDATA[^eNew York New York]]></publisher-loc>
<publisher-name><![CDATA[Wiley- Interscience]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B19">
<label>19</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ruff]]></surname>
<given-names><![CDATA[T.A]]></given-names>
</name>
<name>
<surname><![CDATA[Lewis]]></surname>
<given-names><![CDATA[R.J]]></given-names>
</name>
</person-group>
<article-title xml:lang="en"><![CDATA[Clinical aspects of ciguatera: an overview", Memoirs of the Queensland Museum]]></article-title>
<source><![CDATA[Nature]]></source>
<year>1994</year>
<volume>34</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>609–619</page-range></nlm-citation>
</ref>
<ref id="B20">
<label>20</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sakamoto]]></surname>
<given-names><![CDATA[B.]]></given-names>
</name>
<name>
<surname><![CDATA[Nagai]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
<name>
<surname><![CDATA[Hokama]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
</person-group>
<article-title xml:lang="en"><![CDATA[Stimulators of Gambierdiscus toxicus (Dinophycease) growth: the possible role of gambieric acid-A as an endogenous growth enhancer]]></article-title>
<source><![CDATA[Phycologia]]></source>
<year>1996</year>
<volume>35</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>350-353</page-range></nlm-citation>
</ref>
<ref id="B21">
<label>21</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sarkar]]></surname>
<given-names><![CDATA[R.R.]]></given-names>
</name>
<name>
<surname><![CDATA[Pal]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Chattopadhyay]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
</person-group>
<article-title xml:lang="en"><![CDATA[Role of two toxinproducing plankton and their efect on phytoplankton system- Amathematical study supported by experimental findings]]></article-title>
<source><![CDATA[BioSystems]]></source>
<year>2005</year>
<volume>80</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>11-23</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
