<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1409-1429</journal-id>
<journal-title><![CDATA[Revista Costarricense de Salud Pública]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. costarric. salud pública]]></abbrev-journal-title>
<issn>1409-1429</issn>
<publisher>
<publisher-name><![CDATA[Asociación Costarricense de Salud Pública]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1409-14292019000100096</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Mecanismo carcinogénico asociado a la exposición al Bisfenol A]]></article-title>
<article-title xml:lang="en"><![CDATA[Carcinogenic mechanism associated of Bisphenol A exposure]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Flores Sandí]]></surname>
<given-names><![CDATA[Grettchen]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Costa Rica Escuela de Medicina Legal Departamento Clínico de Medicina Legal]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Costa Rica</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2019</year>
</pub-date>
<volume>28</volume>
<numero>1</numero>
<fpage>96</fpage>
<lpage>104</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_arttext&amp;pid=S1409-14292019000100096&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_abstract&amp;pid=S1409-14292019000100096&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_pdf&amp;pid=S1409-14292019000100096&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción:  El Bisfenol A (BPA) es un producto químico al que los seres humanos están expuestos ampliamente por la vía oral, inhalación y transdérmica.  Justificación:  Dada la importancia de la patología oncológica que puede estar asociada a exposición a este químico, resulta imprescindible comprender mejor sus posibles mecanismos de acción asociados a carcinogénesis.  Objetivo General:  Investigar el mecanismo carcinogénico asociado a la exposición a BPA.  Resultados:  Aunque la mayoría de las investigaciones se han orientado hacia el efecto disruptor endocrino, con la limitante que los estudios in vivo son realizados en animales, existen estudios recientes que muestran su posible efecto carcinogénico en tejidos humanos. Sin embargo, se requiere más investigación sobre el papel del BPA de dosis baja (como ocurre en condiciones ambientales normales) y su efecto en la regulación de los cambios globales de expresión génica y las alteraciones epigenéticas en las células, que permitan establecer vínculos con carcinogénesis; esta revisión demuestra que los estudios realizados hasta la fecha señalan varios factores que pueden estar involucrados, como efectos mutagénicos que incluyen cambios en la transcripción génica y enzimáticos que promueven la proliferación celular limitando la apoptosis y favorecen la angiogénesis y migración de células tumorales.  Conclusión:  Si bien en la actualidad se reconoce que la célula cancerígena adquiere características patológicas que le ayudan a sobrevivir en el organismo, estas características obedecen a mecanismos moleculares genéticos y epigéneticos, muchos de los cuales han sido descritos para el caso de la exposición humana al BPA.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction:  Bisphenol A (BPA) is a chemical to which humans are extensively exposed orally, inhaled and transdermally.  Justification:  Given the importance of the oncological pathology that may be associated with exposure to this chemical, it is essential to better understand its possible mechanisms of action associated with carcinogenesis.  Objective:  To investigate the carcinogenic mechanism associated with BPA exposure.  Results:  Although the majority of investigations have been oriented towards the endocrine disrupting effect, with the limitation that in vivo studies are carried out in animals, recent studies have shown that they can be carcinogenic in human tissues. However, more research is required on the role of low-dose BPA (as occurs under normal environmental conditions) and its effect on the regulation of global changes in gene expression and epigenetic alterations in cells, which allow establishing links with carcinogenesis; this review shows that the studies carried out to date point to several factors that may be involved, such as mutagenic effects that include changes in gene transcription and enzymes that promote cell proliferation, limiting apoptosis and promoting angiogenesis and migration of tumor cells.  Conclusion:  Although it is currently recognized that the cancer cell acquires pathological characteristics that help it to survive in the organism, these characteristics are due to genetic and epigenetic molecular mechanisms, many of which have been described for the case of human exposure to BPA.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Bisfenol A]]></kwd>
<kwd lng="es"><![CDATA[Carcinogénesis]]></kwd>
<kwd lng="es"><![CDATA[Mecanismo]]></kwd>
<kwd lng="es"><![CDATA[Genética]]></kwd>
<kwd lng="es"><![CDATA[Epigénetica]]></kwd>
<kwd lng="en"><![CDATA[Bisphenol A, Carcinogenesis]]></kwd>
<kwd lng="en"><![CDATA[Molecular mechanism]]></kwd>
<kwd lng="en"><![CDATA[Genetics, Epigenetic]]></kwd>
</kwd-group>
</article-meta>
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