<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1409-0015</journal-id>
<journal-title><![CDATA[Medicina Legal de Costa Rica]]></journal-title>
<abbrev-journal-title><![CDATA[Med. leg. Costa Rica]]></abbrev-journal-title>
<issn>1409-0015</issn>
<publisher>
<publisher-name><![CDATA[Asociación Costarricense de Medicina Forense]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1409-00152019000100006</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Carcinoma ductal in situ de la mama con características apocrinas: reporte de un caso]]></article-title>
<article-title xml:lang="en"><![CDATA[Ductal carcinoma in situ of the breast with apocrine characteristics: case report]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González Ramírez]]></surname>
<given-names><![CDATA[Daniel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Madriz de Haan]]></surname>
<given-names><![CDATA[Pedro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Viloria González]]></surname>
<given-names><![CDATA[Tibisay]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Calderón Guardia Servicio de Patología ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Calderón Guardia Servicio de Patología ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<aff id="Af3">
<institution><![CDATA[,Hospital Calderón Guardia Servicio de Patología ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2019</year>
</pub-date>
<volume>36</volume>
<numero>1</numero>
<fpage>6</fpage>
<lpage>13</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_arttext&amp;pid=S1409-00152019000100006&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_abstract&amp;pid=S1409-00152019000100006&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_pdf&amp;pid=S1409-00152019000100006&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen Se presenta el caso de una femenina de 69 años con un carcinoma ductal in situ de la mama, el cual presentaba diferenciación apocrina y alto grado nuclear. La forma de presentación clínica se hizo patente en forma de microcalcificaciones detectadas en la mamografía, y corroboradas histológicamente como comedonecrosis. La diferenciación apocrina se comprobó por medio de tinciones de inmunohistoquímica. El diagnóstico se realizó en una biopsia excisional, pero dado a que uno de los márgenes se encontraba comprometido, la paciente se sometió posteriormente a una mastectomía.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract We present the case of a 69 year old female diagnosed with a ductal in situ carcinoma of the breast. The tumor had apocrine differentiation and a high nuclear grade. The clinical presentation corresponded to microcalcifications detected on mammography, which were histologically patent in the form of comedo type necrosis. The aforementioned apocrine differentiation was reassured using the aid of immunohistochemistry. The biopsy was an excisional biopsy, but due to positive quirurgical margins, the patient was later reintervened for total mastectomy.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Carcinoma ductal in situ]]></kwd>
<kwd lng="es"><![CDATA[apocrino]]></kwd>
<kwd lng="es"><![CDATA[escala de van Nuys]]></kwd>
<kwd lng="es"><![CDATA[receptores estrogénicos]]></kwd>
<kwd lng="es"><![CDATA[receptores de progesterona]]></kwd>
<kwd lng="es"><![CDATA[receptores de andrógenos]]></kwd>
<kwd lng="es"><![CDATA[GCDFP15]]></kwd>
<kwd lng="en"><![CDATA[In situ ductal carcinoma]]></kwd>
<kwd lng="en"><![CDATA[apocrine carcinoma]]></kwd>
<kwd lng="en"><![CDATA[van Nuys scale]]></kwd>
<kwd lng="en"><![CDATA[estrogen receptors]]></kwd>
<kwd lng="en"><![CDATA[progesterone receptors]]></kwd>
<kwd lng="en"><![CDATA[androgen receptors]]></kwd>
<kwd lng="en"><![CDATA[GCDFP15]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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