<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1409-0015</journal-id>
<journal-title><![CDATA[Medicina Legal de Costa Rica]]></journal-title>
<abbrev-journal-title><![CDATA[Med. leg. Costa Rica]]></abbrev-journal-title>
<issn>1409-0015</issn>
<publisher>
<publisher-name><![CDATA[Asociación Costarricense de Medicina Forense]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1409-00152016000100103</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Intoxicación por acetaminofén en adultos]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vargas Castro]]></surname>
<given-names><![CDATA[María Paula]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,marivargas29@gmail.com  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2016</year>
</pub-date>
<volume>33</volume>
<numero>1</numero>
<fpage>103</fpage>
<lpage>109</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_arttext&amp;pid=S1409-00152016000100103&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_abstract&amp;pid=S1409-00152016000100103&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_pdf&amp;pid=S1409-00152016000100103&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: El acetaminofén se ha convertido en el analgésico más ampliamente disponible alrededor del mundo. Aunque se considera muy seguro a dosis terapéuticas, la sobredosis puede conducir a necrosis hepática y es una de las causas principales de insuficiencia hepática aguda. La hepatitis inducida por acetaminofén es de inicio agudo, rápidamente progresiva y se caracteriza por una marcada elevación de las transaminasas. Las manifestaciones iniciales pueden ser leves e inespecíficas, por lo tanto, la medición de la concentración sérica del fármaco es crítica cuando existe sospecha de sobredosis. El nivel debe ser evaluado de acuerdo según el nomograma modificado de Rumack-Matthew para determinar el uso de la N-acetilcisteína (NAC), un antídoto eficaz si se utiliza con prontitud. Este artículo proporciona una visión general de la fisiopatología, la presentación, el diagnóstico y presenta las opciones terapéuticas actuales disponibles para tratar esta condición.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract: Acetaminophen has become the most widely available analgesic around the world. Although it&#8217;s considered remarkably safe at therapeutic doses, its overdose can lead to hepatic necrosis and its one of the principal causes of acute liver failure. Acetaminophen-induced hepatitis is acute in onset, progresses rapidly and is characterized by a marked elevation in aminotransferases. Initial manifestations may be mild and nonspecific, thus, measurement of serum acetaminophen concentration is critical when an overdose is suspected. The level should be evaluated according to the modified Rumack-Matthew nomogram to determine the use of N-acetylcystein (NAC), an effective antidote if used promptly. This article provides an overview of the pathophysiology, presentation, diagnosis of acetaminophen poisoning and presents the actual therapeutic options available to treat this condition.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Intoxicación con acetaminofén]]></kwd>
<kwd lng="es"><![CDATA[N-acetilcisteína]]></kwd>
<kwd lng="es"><![CDATA[nomograma de Rumack Matthew]]></kwd>
<kwd lng="es"><![CDATA[hepatotoxicidad]]></kwd>
<kwd lng="es"><![CDATA[Acetaminophen overdose]]></kwd>
<kwd lng="es"><![CDATA[N-acetylcysteine]]></kwd>
<kwd lng="es"><![CDATA[Rumack-Matthew nomogram]]></kwd>
<kwd lng="es"><![CDATA[Hepatotoxicity]]></kwd>
</kwd-group>
</article-meta>
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