<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0379-3982</journal-id>
<journal-title><![CDATA[Revista Tecnología en Marcha]]></journal-title>
<abbrev-journal-title><![CDATA[Tecnología en Marcha]]></abbrev-journal-title>
<issn>0379-3982</issn>
<publisher>
<publisher-name><![CDATA[Instituto Tecnológico de Costa Rica]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0379-39822024000400152</article-id>
<article-id pub-id-type="doi">10.18845/tm.v37i4.6943</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Alergia al ácido acetilsalicílico (AAS) en el contexto de AINEs: navegando desde una perspectiva inmunitaria]]></article-title>
<article-title xml:lang=""><![CDATA[Acetylsalicylic Acid (ASA) allergy in the context of NSAIDs: navigating from an immune perspective]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Barrantes-Alvarado]]></surname>
<given-names><![CDATA[Reychell]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Coronado-Salazar]]></surname>
<given-names><![CDATA[Julyana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Díaz-Méndez]]></surname>
<given-names><![CDATA[Donalld]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Monge-Brenes]]></surname>
<given-names><![CDATA[Andrés]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Salas-Campos]]></surname>
<given-names><![CDATA[Alison]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Tecnológico de Costa Rica  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Costa Rica</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto Tecnológico de Costa Rica.  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Costa Rica</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Instituto Tecnológico de Costa Rica  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Costa Rica</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Instituto Tecnológico de Costa Rica  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Costa Rica</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Instituto Tecnológico de Costa Rica  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Costa Rica</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2024</year>
</pub-date>
<volume>37</volume>
<numero>4</numero>
<fpage>152</fpage>
<lpage>161</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_arttext&amp;pid=S0379-39822024000400152&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_abstract&amp;pid=S0379-39822024000400152&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_pdf&amp;pid=S0379-39822024000400152&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen Los antiinflamatorios no esteroideos (AINEs) se utilizan en todo el mundo para tratar el dolor y la inflamación; sin embargo, pueden desencadenar varios tipos de reacciones de hipersensibilidad a fármacos en todos los grupos de edad. Un número significativo de reacciones de hipersensibilidad a los AINEs se deben a mecanismos inmunológicos. Con el fin de proporcionar una base que permita una mejor comprensión y gestión médica a la alergia al ácido acetilsalicílico (AAS) en el contexto de antiinflamatorio no esteroide (AINEs), este articulo tiene el propósito de revisar los principales aspectos relativos a las causas, mecanismo inmunológico, síntomas, diagnóstico y opciones de tratamiento relacionados con esta alergia. Los AINEs se clasifican según su estructura química y su selectividad para inhibir las enzimas COX. Se resaltan las ventajas de los AINEs selectivos de COX-2 al minimizar los efectos secundarios gastrointestinales, y se destaca el AAS como un fármaco comúnmente recetado debido a su actividad multifuncional, incluida la prevención del accidente cerebrovascular y el infarto de miocardio.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Nonsteroidal anti-inflammatory drugs (NSAIDs) are used worldwide to treat pain and inflammation; however, they can trigger various types of drug hypersensitivity reactions in all age groups. A significant number of hypersensitivity reactions to NSAIDs are due to immunological mechanisms. In order to provide a basis for better understanding and medical management of acetylsalicylic acid (ASA) allergy in the context of nonsteroidal anti-inflammatory drugs (NSAIDs), this article aims to review the main aspects regarding the causes, immunologic mechanism, symptoms, diagnosis, and treatment options related to this allergy. NSAIDs are classified according to their chemical structure and their selectivity to inhibit COX enzymes. The advantages of COX-2 selective NSAIDs in minimizing gastrointestinal side effects are highlighted, and ASA is highlighted as a commonly prescribed drug because of its multifunctional activity, including prevention of stroke and myocardial infarction.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Intolerancia a la aspirina]]></kwd>
<kwd lng="es"><![CDATA[inflamatorio]]></kwd>
<kwd lng="es"><![CDATA[ciclooxigenasa (COX)]]></kwd>
<kwd lng="es"><![CDATA[tromboxanos]]></kwd>
<kwd lng="es"><![CDATA[prostaglandinas]]></kwd>
<kwd lng="es"><![CDATA[prostaciclina]]></kwd>
<kwd lng="es"><![CDATA[antinocicepción]]></kwd>
<kwd lng="en"><![CDATA[Aspirin intolerance]]></kwd>
<kwd lng="en"><![CDATA[inflammatory]]></kwd>
<kwd lng="en"><![CDATA[cyclooxygenase (COX)]]></kwd>
<kwd lng="en"><![CDATA[thromboxanes]]></kwd>
<kwd lng="en"><![CDATA[prostaglandins]]></kwd>
<kwd lng="en"><![CDATA[prostacyclin]]></kwd>
<kwd lng="en"><![CDATA[antinociception]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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