<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0379-3982</journal-id>
<journal-title><![CDATA[Revista Tecnología en Marcha]]></journal-title>
<abbrev-journal-title><![CDATA[Tecnología en Marcha]]></abbrev-journal-title>
<issn>0379-3982</issn>
<publisher>
<publisher-name><![CDATA[Instituto Tecnológico de Costa Rica]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0379-39822022000300141</article-id>
<article-id pub-id-type="doi">10.18845/tm.v35i2.5653</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Diseño de un biorreactor tipo tanque agitado para el crecimiento de Rhodococcus opacus]]></article-title>
<article-title xml:lang="en"><![CDATA[Design of a stirred tank type bioreactor for the growth of Rhodococcus opacus]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bogantes-Portuguez]]></surname>
<given-names><![CDATA[Pablo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Tecnológico de Costa Rica  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Costa Rica</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2022</year>
</pub-date>
<volume>35</volume>
<numero>3</numero>
<fpage>141</fpage>
<lpage>157</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_arttext&amp;pid=S0379-39822022000300141&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_abstract&amp;pid=S0379-39822022000300141&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_pdf&amp;pid=S0379-39822022000300141&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen En este artículo se presenta el diseño de un biorreactor de tipo tanque agitado asistido por microcontrolador utilizando conceptos de simplicidad de uso, modularidad, estética y ergonomía, según las necesidades de la empresa Cibus 3.0. El tanque cuenta con tres partes principales tapa, dispone sus elementos según su uso; caja de sensores, dispositivo que utiliza sensores de pH, temperatura y turbidez del medio; y tanque, con una capacidad volumétrica de 21.5 L. Se acopló un vaporizador de mano genérico como método de esterilización in situ. Para evaluar la eficiencia de esterilización se realizaron muestreos superficiales en las zonas más críticas de formación de biofilms (tapa, tubos, pared, impulsor y flecha), tras fermentaciones de E. coli y R. opacus. Se demostró que la máquina de vapor no cumple con el objetivo de eliminar la contaminación, logrando una esterilización del 92%. Sin embargo, el uso de autoclave permitió el rendimiento esperado de esterilización, esto se comprobó al realizar simulaciones de fermentación con medio estéril y no presentar contaminación al finalizar el ensayo. Se determinó la posibilidad de utilizar sensores de pH, sólidos suspendidos y temperatura tomando parte del medio para cada repetición sin afectar la inocuidad del sistema. De esta manera se introduce un dispositivo capaz de tomar las mediciones por medio de microcontrolador. Con el fin de corroborar la funcionalidad del equipo diseñado, se realizaron tres fermentaciones con la bacteria R. opacus, donde se obtuvieron curvas de crecimiento validando el funcionamiento del diseño alrededor del usuario y del proceso.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract This article presents the design of a microcontroller-assisted stirred tank bioreactor using concepts of simplicity of use, modularity, aesthetics, and ergonomics, according to the needs of the Cibus 3.0 company. The tank has three main parts: lid (it has its elements according to its use); sensor box (device that uses pH sensors, temperature, and turbidity of the medium); and tank (with a volumetric capacity of 21.5 L). A generic handheld vaporizer was attached as a method of in situ sterilization. To evaluate the efficiency of sterilization, surface samplings were carried out in the most critical areas of biofilm formation (lid, tubes, wall, impeller, and arrow), after fermentations of E. coli and R. opacus. The steam engine shown not to meet the goal of eliminating contamination, achieving 92% sterilization. However, the use of an autoclave allowed the expected sterilization performance, this was verified when simulating fermentation with sterile medium and not presenting contamination at the end of the test. The possibility of using pH, suspended solids and temperature sensors was determined, taking part of the medium for each repetition without contaminating of the system. In this way, a device capable of taking measurements by means of a microcontroller is introduced. To corroborate the functionality of the designed equipment, three fermentations were carried out with the R. opacus bacteria, where growth curves were obtained validating the operation of the design around the user and the process.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Biorreactor]]></kwd>
<kwd lng="es"><![CDATA[configuración modular]]></kwd>
<kwd lng="es"><![CDATA[Rhodococcus opacus]]></kwd>
<kwd lng="es"><![CDATA[esterilización]]></kwd>
<kwd lng="en"><![CDATA[Bioreactor]]></kwd>
<kwd lng="en"><![CDATA[modular configuration]]></kwd>
<kwd lng="en"><![CDATA[Rhodococcus opacus]]></kwd>
<kwd lng="en"><![CDATA[sterilization]]></kwd>
</kwd-group>
</article-meta>
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