<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0379-3982</journal-id>
<journal-title><![CDATA[Revista Tecnología en Marcha]]></journal-title>
<abbrev-journal-title><![CDATA[Tecnología en Marcha]]></abbrev-journal-title>
<issn>0379-3982</issn>
<publisher>
<publisher-name><![CDATA[Instituto Tecnológico de Costa Rica]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0379-39822021000200037</article-id>
<article-id pub-id-type="doi">10.18845/tm.v34i2.5016</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Aplicación del valor de tono de color directo para el control cromático del proceso de recubrimiento de tabletas farmacéuticas]]></article-title>
<article-title xml:lang="en"><![CDATA[Application of the spot color tone value at pharmaceutical tablet coating process control]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Murillo-Fernández]]></surname>
<given-names><![CDATA[Mac Arturo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Montero-Zeledón]]></surname>
<given-names><![CDATA[Ernesto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gutiérrez-Fallas]]></surname>
<given-names><![CDATA[Dionisio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Melgosa-Latorre]]></surname>
<given-names><![CDATA[Manuel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pacheco-Molina]]></surname>
<given-names><![CDATA[Jorge]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Tecnológico de Costa Rica Escuela de Física ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Costa Rica</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto Tecnológico de Costa Rica Escuela de Física ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Costa Rica</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Instituto Tecnológico de Costa Rica Escuela de Física ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Costa Rica</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidad de Granada Departamento de Óptica ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Spain</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Universidad de Costa Rica Facultad de Farmacia ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Costa Rica</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2021</year>
</pub-date>
<volume>34</volume>
<numero>2</numero>
<fpage>37</fpage>
<lpage>47</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_arttext&amp;pid=S0379-39822021000200037&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_abstract&amp;pid=S0379-39822021000200037&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_pdf&amp;pid=S0379-39822021000200037&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen Se propone una aplicación novedosa de la fórmula SCTV (Spot Color Tone Value) proveniente de la industria de reproducción gráfica, para el control de la calidad del proceso de recubrimiento de tabletas farmacéuticas. Se analizan dos procedimientos: uno mediante la obtención de los espectros de reflectancia, de los cuales se pueden derivar los atributos cromáticos, y otro a partir de la obtención de las coordenadas de color de una imagen fotográfica calibrada. Nuestro objetivo es reducir la necesidad de intervención, extracción y destrucción de tabletas durante el control de calidad, además de facilitar el control y evaluación del proceso de forma remota, generando respuestas en tiempo real para la toma de decisiones.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract A novel application of the SCTV (Spot Color Tone Value) formula from the graphic reproduction industry is proposed for the quality control of the pharmaceutical tablet coating process. Two procedures are analyzed: one by obtaining reflectance spectra, from which the chromatic attributes can be derived, and the other from obtaining the color coordinates of a calibrated photographic image. Our goal is to reduce the intervention, extraction and destruction of tablets during quality control, as well as simplify the control and evaluation of the process remotely, generating real-time responses for taking decisions.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Valor de Tono de Color Directo]]></kwd>
<kwd lng="es"><![CDATA[Murray-Davies]]></kwd>
<kwd lng="es"><![CDATA[Yule-Nielsen]]></kwd>
<kwd lng="es"><![CDATA[CIEDE2000]]></kwd>
<kwd lng="es"><![CDATA[Poder de Dispersión]]></kwd>
<kwd lng="es"><![CDATA[Kubelka Munk]]></kwd>
<kwd lng="en"><![CDATA[Spot Color Tone Value]]></kwd>
<kwd lng="en"><![CDATA[Murray-Davies]]></kwd>
<kwd lng="en"><![CDATA[Yule-Nielsen]]></kwd>
<kwd lng="en"><![CDATA[CIEDE2000]]></kwd>
<kwd lng="en"><![CDATA[Scattering Capability]]></kwd>
<kwd lng="en"><![CDATA[Kubelka Munk]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Murray]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Monochrome Reproduction in Photoengraving]]></article-title>
<source><![CDATA[Journal of the Franklin Institute]]></source>
<year>1936</year>
<volume>221</volume>
<page-range>721-44</page-range></nlm-citation>
</ref>
<ref id="B2">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Yule]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Nielsen]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The Penetration of Light into Paper and its Effect on Halftone Reproductions,]]></article-title>
<source><![CDATA[TAGA Proceedings]]></source>
<year>1951</year>
<volume>3</volume>
<page-range>. 65-76</page-range></nlm-citation>
</ref>
<ref id="B3">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Neugebauer]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Die theoretischen grundlagen des mehrfarbendrucks]]></article-title>
<source><![CDATA[Zeitscrift fur wissenschaftliche Photographie]]></source>
<year>1937</year>
<volume>36</volume>
<page-range>73-89</page-range></nlm-citation>
</ref>
<ref id="B4">
<nlm-citation citation-type="journal">
<collab>H. D.C</collab>
<article-title xml:lang=""><![CDATA[Process analytical technologies in the pharmaceutical industry: the FDA&#8217;s PAT initiative]]></article-title>
<source><![CDATA[Anal Bioanal Chem]]></source>
<year>2006</year>
<volume>384</volume>
<page-range>1036-42</page-range></nlm-citation>
</ref>
<ref id="B5">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Reitter]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[FDA Draft Guidance Document Comments on Use of Inks, Pigments, Flavors and Taggants to Guard Against Counterfeiting]]></article-title>
<source><![CDATA[ColorCon Inc]]></source>
<year>2009</year>
</nlm-citation>
</ref>
<ref id="B6">
<nlm-citation citation-type="">
<collab>ISO</collab>
<source><![CDATA[Verner, Geneva: ISO copyrigth office]]></source>
<year>2018</year>
</nlm-citation>
</ref>
<ref id="B7">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Deshpande]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Green]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A simplified method of predicting the colorimetry of spot color overprints]]></article-title>
<source><![CDATA[de 18th Color Imaging Conference Final Program and Proceedings, London, UK]]></source>
<year>2010</year>
</nlm-citation>
</ref>
<ref id="B8">
<nlm-citation citation-type="journal">
<collab>C. 15</collab>
<article-title xml:lang=""><![CDATA[Technical Report Colorimetry,]]></article-title>
<source><![CDATA[Commission Internationale de léclairage, CIE, Vienna, Austria]]></source>
<year>2018</year>
</nlm-citation>
</ref>
<ref id="B9">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kubelka]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Munk]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[An Article on Optics of Paint Layers]]></article-title>
<source><![CDATA[Zeit. Für Tekn. Physik]]></source>
<year>1931</year>
<page-range>593</page-range></nlm-citation>
</ref>
<ref id="B10">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Becerir]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Color Concept in Textiles: A Review]]></article-title>
<source><![CDATA[Journal of Textile Engineering &amp; Fashion Technology]]></source>
<year>2017</year>
<volume>1</volume>
<page-range>1-5</page-range></nlm-citation>
</ref>
<ref id="B11">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Schabbach]]></surname>
<given-names><![CDATA[B. F.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Colouring of opaque ceramic glaze with zircon pigments: Formulation with simplified Kubelka-Munk model]]></article-title>
<source><![CDATA[Journal of the European Ceramic Society]]></source>
<year>2011</year>
<page-range>659-64</page-range></nlm-citation>
</ref>
<ref id="B12">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Barron]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Predicción del color en mezclas de arcillas con óxidos de hierro: aplicación del analisis de Kubelka - Munk]]></article-title>
<source><![CDATA[Bol. Soc. Esp. Ceram. Vidrio]]></source>
<year>1987</year>
<page-range>299-304</page-range></nlm-citation>
</ref>
<ref id="B13">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Murillo]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Rodríguez]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
<name>
<surname><![CDATA[Heredia]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Melgosa]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Pacheco]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Montero]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Gutiérrez]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Color evolution during a coating process of pharmaceutical tablet cores by random spraying,]]></article-title>
<source><![CDATA[CR&amp;A]]></source>
<year>2019</year>
<page-range>160-7</page-range></nlm-citation>
</ref>
<ref id="B14">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Berns]]></surname>
<given-names><![CDATA[R. S.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Billmeyer and Saltzman&#8217;s Principles of Color Technology]]></article-title>
<source><![CDATA[Rochester, NY: Wiley]]></source>
<year>2000</year>
</nlm-citation>
</ref>
<ref id="B15">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Artigas]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Teoría de Kubelka-Munk]]></article-title>
<source><![CDATA[de Tecnología del Color, Zaragoza, Valencia, Universitat de Valencia]]></source>
<year>2002</year>
<page-range>291-4</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
