<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0379-3982</journal-id>
<journal-title><![CDATA[Revista Tecnología en Marcha]]></journal-title>
<abbrev-journal-title><![CDATA[Tecnología en Marcha]]></abbrev-journal-title>
<issn>0379-3982</issn>
<publisher>
<publisher-name><![CDATA[Instituto Tecnológico de Costa Rica]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0379-39822019000400133</article-id>
<article-id pub-id-type="doi">10.18845/tm.v32i4.4798</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Producción de proteínas recombinantes a partir de animales transgénicos: Sistemas y aplicaciones]]></article-title>
<article-title xml:lang="en"><![CDATA[Recombinant protein production from transgenic animals: Systems and applications]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Alvarado-Madrigal]]></surname>
<given-names><![CDATA[María Fernanda]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Chavarría-Quirós]]></surname>
<given-names><![CDATA[Tannia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Leiva-Montero]]></surname>
<given-names><![CDATA[Brayan]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mora-Román]]></surname>
<given-names><![CDATA[Juan José]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Uni versidad de Costa Rica Facultad de Farmacia ]]></institution>
<addr-line><![CDATA[San José ]]></addr-line>
<country>Costa Rica</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Costa Rica Estudiante de Licenciatura en Farmacia Facultad de Farmacia]]></institution>
<addr-line><![CDATA[San José ]]></addr-line>
<country>Costa Rica</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad de Costa Rica Estudiante de Licenciatura en Farmacia Facultad de Farmacia]]></institution>
<addr-line><![CDATA[San José ]]></addr-line>
<country>Costa Rica</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidad de Costa Rica Departamento de Farmacia Industrial Facultad de Far macia]]></institution>
<addr-line><![CDATA[San José ]]></addr-line>
<country>Costa Rica</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2019</year>
</pub-date>
<volume>32</volume>
<numero>4</numero>
<fpage>133</fpage>
<lpage>144</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_arttext&amp;pid=S0379-39822019000400133&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_abstract&amp;pid=S0379-39822019000400133&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_pdf&amp;pid=S0379-39822019000400133&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen El uso de animales transgénicos para la producción de proteínas recombinantes con fines terapéuticos ha sido una alternativa utilizada para la producción de medicamentos. La habilidad de realizar complejas modificaciones post traduccionales de una manera eficiente es una ventaja que este tipo de tecnología posee sobre el uso de otros organismos transgénicos. Por esta razón, a lo largo de los años se han desarrollado diferentes animales transgénicos (rumiantes, conejos, cerdos, aves e insectos) y se han estudiado distintos sistemas (leche, huevo, sangre, orina y fluido seminal) para la obtención de proteínas recombinantes. Cada animal y cada sistema cuenta con ventajas y desventajas, las cuales deben ser consideradas antes de comenzar el proceso productivo de la proteína de interés. Medicamentos como el ATryn®, el Ruconest® y el Kanuma® ya han sido aprobados por la FDA para la administración en humanos. El futuro de este tipo de preparados debe ser tomado en consideración, pues existen varias proteínas terapéuticas que se hallan en fase de investigación o a la espera de ser aprobadas y comercializadas.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract The use of transgenic animals for the production of recombinant proteins for therapeutic purposes has been an alternative used for the production of drugs. The ability to make complex post-translational modifications in an efficient manner is an advantage that this type of technology has over the use of other transgenic organisms. For this reason, different transgenic animals (ruminants, rabbits, pigs, birds and insects) have been developed over the years and different systems (milk, egg, blood, urine and seminal fluid) have been studied to obtain recombinant proteins. Each animal and each system has advantages and disadvantages, which should be considered before starting the productive process of the protein of interest. Drugs such as ATryn®, Ruconest® and Kanuma® have already been approved by the FDA for human administration. The future of this type of preparations must be considered, given that there are several therapeutic proteins that are in the research phase or waiting to be approved and commercialized.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Biotecnología]]></kwd>
<kwd lng="es"><![CDATA[Ingeniería Genética]]></kwd>
<kwd lng="es"><![CDATA[animales transgénicos]]></kwd>
<kwd lng="es"><![CDATA[proteínas recombinantes]]></kwd>
<kwd lng="en"><![CDATA[Biotechnology]]></kwd>
<kwd lng="en"><![CDATA[Genetic Engineering]]></kwd>
<kwd lng="en"><![CDATA[transgenic animals]]></kwd>
<kwd lng="en"><![CDATA[recombinant proteins]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>(1)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Almeida]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[H. Amaral]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Lobão]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Drugs obtained by biotechnology processing]]></article-title>
<source><![CDATA[Brazilian Journal of Pharmaceutical Sciences]]></source>
<year>2011</year>
<volume>47</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>199-207</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>(2)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Buchholz]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Collins]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The roots-a short history of industrial microbiology and biotechnology]]></article-title>
<source><![CDATA[Applied Microbiology and Biotechnology]]></source>
<year>2013</year>
<volume>97</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>3747-62</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>(3)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Schmidt]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Belated approval of first recombinant protein from animal]]></article-title>
<source><![CDATA[Nature Biotechnology]]></source>
<year>2006</year>
<volume>24</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>877</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>(4)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Evens]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Kaitin]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The evolution of biotecnology and its impact on health care]]></article-title>
<source><![CDATA[Health Affairs]]></source>
<year>2015</year>
<volume>34</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>210-9</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>(5)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[K. Ganguly]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Croft]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Singh]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Sinha]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Balganesh]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Biomedicine and Biotechnology: Public Health Impact]]></article-title>
<source><![CDATA[BioMed Research International]]></source>
<year>2014</year>
<page-range>1-2</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>(6)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[V. Shepelev]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[V. Kalinichenko]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[V. Deykin]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[V. Korobko]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Production of Recombinant Proteins in the Milk of Transgenic Animals: Current State and Prospects]]></article-title>
<source><![CDATA[Acta Naturae]]></source>
<year>2018</year>
<volume>10</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>40-7</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>(7)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[P. Zhang]]></surname>
<given-names><![CDATA[Y. H]]></given-names>
</name>
<name>
<surname><![CDATA[Sun]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Ma]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Biomanufacturing: history and perspective]]></article-title>
<source><![CDATA[Journal of Industrial Microbiology &amp; Biotechnology]]></source>
<year>2017</year>
<volume>44</volume>
<numero>4-5</numero>
<issue>4-5</issue>
<page-range>773-84</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>(8)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Berg]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[E. Mertz]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Personal Reflections on the Origins and Emergence of Recombinant DNA Technology]]></article-title>
<source><![CDATA[Genetics]]></source>
<year>2010</year>
<volume>184</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>9-17</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>(9)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sandow]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Landgraf]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Becker]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Seipke]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Equivalent Recombinant Human Insulin Preparations and their Place in Therapy]]></article-title>
<source><![CDATA[European Endrocrinology]]></source>
<year>2015</year>
<volume>11</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>10-6</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>(10)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wirt]]></surname>
<given-names><![CDATA[S. E.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Development of nuclease-mediated site-specific genome modification]]></article-title>
<source><![CDATA[Current Opinion in Immunology]]></source>
<year>2012</year>
<volume>24</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>609-16</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>(11)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[R. Little]]></surname>
<given-names><![CDATA[P. F]]></given-names>
</name>
<name>
<surname><![CDATA[H. Cross]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A cosmid vector that facilitates restriction enzyme mapping]]></article-title>
<source><![CDATA[Proceedings of the National Academy of Sciences of the United States of America]]></source>
<year>1985</year>
<volume>82</volume>
<numero>10</numero>
<issue>10</issue>
<page-range>3159-63</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>(12)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jajesniak]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[S. Wong]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[QuickStep-Cloning: a sequence-independent ligation-free method for rapid construction of recombinant plasmids]]></article-title>
<source><![CDATA[Journal of Biological Engineering]]></source>
<year>2015</year>
<volume>9</volume>
<numero>15</numero>
<issue>15</issue>
</nlm-citation>
</ref>
<ref id="B13">
<label>(13)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mairhofer]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Cserjan-Puschmann]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Striedner]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Nöbauer]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Razzazi-Fazeli]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Grabherr]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Marker-free plasmids for gene therapeutic applications-Lack of antibiotic resistance gene substantially improves the manufacturing process]]></article-title>
<source><![CDATA[Journal of Biotechnology]]></source>
<year>2010</year>
<volume>146</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>130-7</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>(14)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[A. Gossen]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[C. Molijn]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[R. Douglas]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Vijg]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Application of galactose-sensitive E. coli strains as selective hosts for LacZ- plasmids]]></article-title>
<source><![CDATA[Nucleic Acids Research]]></source>
<year>1992</year>
<volume>20</volume>
<numero>12</numero>
<issue>12</issue>
<page-range>3254</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>(15)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Skóra]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Bar&#263;]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Dawiskiba]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Baczy&#324;ska]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Mastalerz-Migas]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Angiogenesis after plasmid VEGF165 gene transfer in an animal model]]></article-title>
<source><![CDATA[Central European Journal of Immunology]]></source>
<year>2013</year>
<volume>38</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>305-9</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>(16)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wegman]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[E. Geuze]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[van der Helm]]></surname>
<given-names><![CDATA[Y. J]]></given-names>
</name>
<name>
<surname><![CDATA[Cumhur Öner]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[A. Dhert]]></surname>
<given-names><![CDATA[W. J]]></given-names>
</name>
<name>
<surname><![CDATA[Alblas]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Gene delivery of bone morphogenetic protein-2 plasmid DNA promotes bone formation in a large animal model]]></article-title>
<source><![CDATA[Journal of Tissue Engineering and Regenerative Medicine]]></source>
<year>2014</year>
<volume>8</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>763-70</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>(17)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Catalano]]></surname>
<given-names><![CDATA[C. E.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Bacteriophage lambda: The path from biology to theranostic agent]]></article-title>
<source><![CDATA[Wiley Interdisciplinary Reviews Nanomedicine and Nabiotechnology]]></source>
<year>2018</year>
<volume>10</volume>
<numero>5</numero>
<issue>5</issue>
</nlm-citation>
</ref>
<ref id="B18">
<label>(18)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ryan]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[M.Gorman]]></surname>
<given-names><![CDATA[S. P.]]></given-names>
</name>
<name>
<surname><![CDATA[Donnelly]]></surname>
<given-names><![CDATA[R. F.]]></given-names>
</name>
<name>
<surname><![CDATA[Gilmore]]></surname>
<given-names><![CDATA[B.F.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Recent advances in bacteriophage therapy: how delivery routes, formulation, concentration and timing influence the success of phage therapy]]></article-title>
<source><![CDATA[Journal of Pharmacy and Pharmacology]]></source>
<year>2011</year>
<volume>63</volume>
<numero>10</numero>
<issue>10</issue>
<page-range>1253-64</page-range></nlm-citation>
</ref>
<ref id="B19">
<label>(19)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fan]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Zeng]]></surname>
<given-names><![CDATA[Z]]></given-names>
</name>
<name>
<surname><![CDATA[Mai]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Yang]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Feng]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Bai]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Preliminary treatment of bovine mastitis caused by Staphylococcus aureus, with trx-SA1, recombinant endolysin of S. aureus bacteriophage IME-SA1]]></article-title>
<source><![CDATA[Veterinary Microbiology]]></source>
<year>2016</year>
<volume>191</volume>
<page-range>65-71</page-range></nlm-citation>
</ref>
<ref id="B20">
<label>(20)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kishor]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Mishra]]></surname>
<given-names><![CDATA[R. R.]]></given-names>
</name>
<name>
<surname><![CDATA[Saraf]]></surname>
<given-names><![CDATA[S. K.]]></given-names>
</name>
<name>
<surname><![CDATA[Kumar]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[K. Srivastav]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Nath]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Phage therapy of staphylococcal chronic osteomyelitis in experimental animal model]]></article-title>
<source><![CDATA[Indian Journal of Medical Research]]></source>
<year>2016</year>
<volume>143</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>87-94</page-range></nlm-citation>
</ref>
<ref id="B21">
<label>(21)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Knorre]]></surname>
<given-names><![CDATA[D. G.]]></given-names>
</name>
<name>
<surname><![CDATA[Kudryashova]]></surname>
<given-names><![CDATA[N. V.]]></given-names>
</name>
<name>
<surname><![CDATA[Godovikova]]></surname>
<given-names><![CDATA[T. S.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Chemical and Functional Aspects of Posttranslational Modification of Proteins]]></article-title>
<source><![CDATA[Acta Naturae]]></source>
<year>2009</year>
<volume>1</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>29-51</page-range></nlm-citation>
</ref>
<ref id="B22">
<label>(22)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Maksimenko]]></surname>
<given-names><![CDATA[O. G.]]></given-names>
</name>
<name>
<surname><![CDATA[Deykin]]></surname>
<given-names><![CDATA[A. V.]]></given-names>
</name>
<name>
<surname><![CDATA[Khodarovich]]></surname>
<given-names><![CDATA[Y. M.]]></given-names>
</name>
<name>
<surname><![CDATA[Georgiev]]></surname>
<given-names><![CDATA[P. G.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Use of Transgenic Animals in Biotechnology: Prospects and Problems]]></article-title>
<source><![CDATA[Acta Naturae]]></source>
<year>2013</year>
<volume>5</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>33-46</page-range></nlm-citation>
</ref>
<ref id="B23">
<label>(23)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Durocher]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
<name>
<surname><![CDATA[Butler]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Expression systems for therapeutic glycoprotein production]]></article-title>
<source><![CDATA[Current Opinion in Biotechnology]]></source>
<year>2009</year>
<volume>20</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>700-7</page-range></nlm-citation>
</ref>
<ref id="B24">
<label>(24)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[L. Demain]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Vaishnav]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Production of recombinant proteins by microbes and higher organisms]]></article-title>
<source><![CDATA[Biotechnology Advances]]></source>
<year>2009</year>
<volume>27</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>297-306</page-range></nlm-citation>
</ref>
<ref id="B25">
<label>(25)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Dove]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Uncorking the biomanufacturing bottleneck]]></article-title>
<source><![CDATA[Nature Biotechnology]]></source>
<year>2002</year>
<volume>20</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>777-9</page-range></nlm-citation>
</ref>
<ref id="B26">
<label>(26)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Houdebine]]></surname>
<given-names><![CDATA[L. M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Production of pharmaceutical proteins by transgenic animals]]></article-title>
<source><![CDATA[Comparative Immunology, Microbiology &amp; Infectious Diseases]]></source>
<year>2009</year>
<volume>32</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>107-21</page-range></nlm-citation>
</ref>
<ref id="B27">
<label>(27)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Dyck]]></surname>
<given-names><![CDATA[M. K]]></given-names>
</name>
<name>
<surname><![CDATA[Lacroix]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Pothier]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Sirard]]></surname>
<given-names><![CDATA[M. -A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Making recombinant proteins in animals - different sys tems, different applications]]></article-title>
<source><![CDATA[Trends in Biotechnology]]></source>
<year>2003</year>
<volume>21</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>394-9</page-range></nlm-citation>
</ref>
<ref id="B28">
<label>(28)</label><nlm-citation citation-type="">
<collab>Organización de las Naciones Unidas para la Alimentación y la Agricultura</collab>
<source><![CDATA[Producción y productos: Animales lecheros]]></source>
<year>2018</year>
</nlm-citation>
</ref>
<ref id="B29">
<label>(29)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Echelard]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Ziomek]]></surname>
<given-names><![CDATA[C. A.]]></given-names>
</name>
<name>
<surname><![CDATA[Meade]]></surname>
<given-names><![CDATA[H. M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Production of recombinant therapeutic proteins in the milk of transgenic animals]]></article-title>
<source><![CDATA[Biopharm International]]></source>
<year>2006</year>
<volume>19</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>36-46</page-range></nlm-citation>
</ref>
<ref id="B30">
<label>30</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Eyestone]]></surname>
<given-names><![CDATA[W. H.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Production and breeding of transgenic cattle using in vitro embryo production technology]]></article-title>
<source><![CDATA[Theriogenology]]></source>
<year>1999</year>
<volume>51</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>509-17</page-range></nlm-citation>
</ref>
<ref id="B31">
<label>(31)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Massoud]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Attal]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Thépot]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Pointu]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[G. Stinnakre]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[C. Théron]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The deleterious effects of human erythropoietin gene driven by the rabbit when acidic protein gene promoter in transgenic rabbits]]></article-title>
<source><![CDATA[Reproduction Nutrition Development]]></source>
<year>1996</year>
<volume>36</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>555-63</page-range></nlm-citation>
</ref>
<ref id="B32">
<label>(32)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Houdebine]]></surname>
<given-names><![CDATA[L. M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The production of pharmaceutical proteins from the milk of transgenic animals]]></article-title>
<source><![CDATA[Reproduction Nutrition Development]]></source>
<year>1995</year>
<volume>35</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>609-17</page-range></nlm-citation>
</ref>
<ref id="B33">
<label>(33)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Poto&#269;nik]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
<name>
<surname><![CDATA[Gantner]]></surname>
<given-names><![CDATA[V.]]></given-names>
</name>
<name>
<surname><![CDATA[Kuterovac]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
<name>
<surname><![CDATA[Cividini]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Mare´s milk: composition and protein fraction in com parison with different milk species]]></article-title>
<source><![CDATA[Mljekarstvo]]></source>
<year>2011</year>
<volume>61</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>107-13</page-range></nlm-citation>
</ref>
<ref id="B34">
<label>(34)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wall]]></surname>
<given-names><![CDATA[R. J.]]></given-names>
</name>
<name>
<surname><![CDATA[Kerr]]></surname>
<given-names><![CDATA[D. E.]]></given-names>
</name>
<name>
<surname><![CDATA[Bondioli]]></surname>
<given-names><![CDATA[K. R.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Transgenic Dairy Cattle: Genetic Engineering on a Large Scale]]></article-title>
<source><![CDATA[Journal of Dairy Science]]></source>
<year>1997</year>
<volume>80</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>2213-24</page-range></nlm-citation>
</ref>
<ref id="B35">
<label>(35)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wilkins]]></surname>
<given-names><![CDATA[T. D.]]></given-names>
</name>
<name>
<surname><![CDATA[Velander]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Isolation of recombinant proteins from milk]]></article-title>
<source><![CDATA[Journal of Cellular Biochemistry]]></source>
<year>1992</year>
<volume>49</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>333-8</page-range></nlm-citation>
</ref>
<ref id="B36">
<label>(36)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Nikolov]]></surname>
<given-names><![CDATA[Z. L.]]></given-names>
</name>
<name>
<surname><![CDATA[Woodward]]></surname>
<given-names><![CDATA[S. L.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Downstream processing of recombinant proteins from transgenic feeds tock]]></article-title>
<source><![CDATA[Current Opinion in Biotechnology]]></source>
<year>2004</year>
<volume>15</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>479-86</page-range></nlm-citation>
</ref>
<ref id="B37">
<label>(37)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Morçöl]]></surname>
<given-names><![CDATA[T.]]></given-names>
</name>
<name>
<surname><![CDATA[He]]></surname>
<given-names><![CDATA[Q.]]></given-names>
</name>
<name>
<surname><![CDATA[D. Bell]]></surname>
<given-names><![CDATA[S. J.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Model Process for Removal of Caseins from Milk of Transgenic Animals]]></article-title>
<source><![CDATA[Biotechnology Progress]]></source>
<year>2001</year>
<volume>17</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>577-82</page-range></nlm-citation>
</ref>
<ref id="B38">
<label>(38)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Harvey]]></surname>
<given-names><![CDATA[A .J.]]></given-names>
</name>
<name>
<surname><![CDATA[Speksnijder]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Baugh]]></surname>
<given-names><![CDATA[L. R.]]></given-names>
</name>
<name>
<surname><![CDATA[Morris]]></surname>
<given-names><![CDATA[J. A.]]></given-names>
</name>
<name>
<surname><![CDATA[Ivarie]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Expression of exogenous protein in the egg white of transgenic chickens]]></article-title>
<source><![CDATA[Nature Biotechnology]]></source>
<year>2002</year>
<volume>20</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>396-9</page-range></nlm-citation>
</ref>
<ref id="B39">
<label>(39)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Park]]></surname>
<given-names><![CDATA[T. S.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Deposition of bioactive human epider mal growth factor in the egg white of transgenic hens using an oviduct-specific minisynthetic promoter]]></article-title>
<source><![CDATA[The FASEB Journal]]></source>
<year>2015</year>
<volume>29</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>2386-96</page-range></nlm-citation>
</ref>
<ref id="B40">
<label>(40)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
<name>
<surname><![CDATA[Zhao]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Bai]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[Fan]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Liu]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Expression Systems and Species Used for Transgenic Animal Bioreactors]]></article-title>
<source><![CDATA[BioMed Research International]]></source>
<year>2013</year>
</nlm-citation>
</ref>
<ref id="B41">
<label>(41)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rehbinder]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[Engelhard]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Hagen]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
<name>
<surname><![CDATA[Jørgensen]]></surname>
<given-names><![CDATA[R. B.]]></given-names>
</name>
<name>
<surname><![CDATA[Pardo-Avellaneda]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Schnieke]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Promises and risks of biopharmaceuticals derived from genetically modified plants and animals]]></article-title>
<source><![CDATA[Berlin: Springer-Verlag Berlin Heidelberg]]></source>
<year>2009</year>
<page-range>26</page-range></nlm-citation>
</ref>
<ref id="B42">
<label>(42)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Swanson]]></surname>
<given-names><![CDATA[M. E.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Production of functional human hemoglobin in transgenic swine]]></article-title>
<source><![CDATA[Biotechnology]]></source>
<year>1992</year>
<volume>10</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>557-9</page-range></nlm-citation>
</ref>
<ref id="B43">
<label>(43)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pursel]]></surname>
<given-names><![CDATA[V. G.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Expression and perfor mance in transgenic pigs]]></article-title>
<source><![CDATA[Journal of Reproduction and Fertility]]></source>
<year>1990</year>
<volume>40</volume>
<page-range>235-45</page-range></nlm-citation>
</ref>
<ref id="B44">
<label>(44)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kerr]]></surname>
<given-names><![CDATA[D. E.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The bladder as a biorreactor: Urothelium production and secretion of growth hormone into urine]]></article-title>
<source><![CDATA[Nature Biotechnology]]></source>
<year>1998</year>
<volume>16</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>75-9</page-range></nlm-citation>
</ref>
<ref id="B45">
<label>(45)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zbikowska]]></surname>
<given-names><![CDATA[H. M.]]></given-names>
</name>
<name>
<surname><![CDATA[Soukhareva]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Behnam]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Chang]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Drews]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Lubon]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The use of the uromodulin promoter to target production of recombinant proteins into urine of transgenic animals]]></article-title>
<source><![CDATA[Transgenic Research]]></source>
<year>2002</year>
<volume>11</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>425-35</page-range></nlm-citation>
</ref>
<ref id="B46">
<label>(46)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zbikowska]]></surname>
<given-names><![CDATA[H. M.]]></given-names>
</name>
<name>
<surname><![CDATA[Soukhareva]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Behnam]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Lubon]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Hammond]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Soukharev]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Uromodulin pro moter directs high-level expression of biologically active human &#945;1-antitrypsin into mouse urine]]></article-title>
<source><![CDATA[Biochemical Journal]]></source>
<year>2002</year>
<volume>365</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>7-11</page-range></nlm-citation>
</ref>
<ref id="B47">
<label>(47)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ryoo]]></surname>
<given-names><![CDATA[Z. Y.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Expression of recombinant human granulocyte macrophage-colony stimulating factor (hGM-CSF) in mouse urine]]></article-title>
<source><![CDATA[Transgenic Research]]></source>
<year>2001</year>
<volume>10</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>193-200</page-range></nlm-citation>
</ref>
<ref id="B48">
<label>(48)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chrenek]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[Makarevich]]></surname>
<given-names><![CDATA[A. V.]]></given-names>
</name>
<name>
<surname><![CDATA[Pivko]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Bulla]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Transgenic Farm Animal Production and Application]]></article-title>
<source><![CDATA[Slovak Journal of Animal Science]]></source>
<year>2010</year>
<volume>43</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>45-9</page-range></nlm-citation>
</ref>
<ref id="B49">
<label>(49)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bertolini]]></surname>
<given-names><![CDATA[L .R.]]></given-names>
</name>
<name>
<surname><![CDATA[Meade]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Lazzarotto]]></surname>
<given-names><![CDATA[C. R.]]></given-names>
</name>
<name>
<surname><![CDATA[T. Martins]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[C. Tavares]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
<name>
<surname><![CDATA[Bertolini]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The transgenic animal platform for biopharmaceutical production]]></article-title>
<source><![CDATA[Transgenic Research]]></source>
<year>2016</year>
<volume>25</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>329-43</page-range></nlm-citation>
</ref>
<ref id="B50">
<label>(50)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wright]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Carver]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Cottom]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Reeves]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Scott]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Simons]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[High Level Expression of Active Human Alpha-1-Antitrypsin in the Milk of Transgenic Sheep]]></article-title>
<source><![CDATA[Biotechnology]]></source>
<year>1991</year>
<volume>9</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>830-4</page-range></nlm-citation>
</ref>
<ref id="B51">
<label>(51)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rudolph]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Technologies and economics for protein production in transgenic animal milk]]></article-title>
<source><![CDATA[Genetic Engineering News]]></source>
<year>1997</year>
<volume>17</volume>
<numero>16</numero>
<issue>16</issue>
<page-range>36-7</page-range></nlm-citation>
</ref>
<ref id="B52">
<label>(52)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lubo&#324;]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
<name>
<surname><![CDATA[Paleyanda]]></surname>
<given-names><![CDATA[R. K.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Vitamin K-dependent protein production in transgenic animals]]></article-title>
<source><![CDATA[Thrombosis and Haemostasis]]></source>
<year></year>
<volume>78</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>532-6</page-range></nlm-citation>
</ref>
<ref id="B53">
<label>(53)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Tomita]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Munetsuna]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
<name>
<surname><![CDATA[Sato]]></surname>
<given-names><![CDATA[T.]]></given-names>
</name>
<name>
<surname><![CDATA[Adachi]]></surname>
<given-names><![CDATA[T.]]></given-names>
</name>
<name>
<surname><![CDATA[Hino]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Hayashi]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Transgenic silkworms produce recom binant human type III procollagen in cocoons]]></article-title>
<source><![CDATA[Nature Biotechnology]]></source>
<year>2003</year>
<volume>21</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>52-6</page-range></nlm-citation>
</ref>
<ref id="B54">
<label>(54)</label><nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Maeda]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Kawai]]></surname>
<given-names><![CDATA[T.]]></given-names>
</name>
<name>
<surname><![CDATA[Obinata]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Fujiwara]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
<name>
<surname><![CDATA[Horuchi]]></surname>
<given-names><![CDATA[T.]]></given-names>
</name>
<name>
<surname><![CDATA[Saeki]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
</person-group>
<source><![CDATA[Nature]]></source>
<year></year>
<volume>315</volume>
<numero>6020</numero>
<issue>6020</issue>
<page-range>592-4</page-range></nlm-citation>
</ref>
<ref id="B55">
<label>(55)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Markaki]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Drabek]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[Livadaras]]></surname>
<given-names><![CDATA[I.]]></given-names>
</name>
<name>
<surname><![CDATA[Craig]]></surname>
<given-names><![CDATA[R. K.]]></given-names>
</name>
<name>
<surname><![CDATA[Grosveld]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
<name>
<surname><![CDATA[Savakis]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Stable expression of human growth hormone over 50 generations in transgenic insect larvae]]></article-title>
<source><![CDATA[Transgenic Research]]></source>
<year>2007</year>
<volume>16</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>99-107</page-range></nlm-citation>
</ref>
<ref id="B56">
<label>(56)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gavin]]></surname>
<given-names><![CDATA[W.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[ATryn®: 1st GE (genetically engineered) animal success story for production of a human recombi nant pharmaceutical]]></article-title>
<source><![CDATA[BMC Proceedings]]></source>
<year>2014</year>
<volume>8</volume>
<numero>^s4</numero>
<issue>^s4</issue>
<supplement>4</supplement>
</nlm-citation>
</ref>
<ref id="B57">
<label>(57)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sánchez]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Gadea]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Animales transgénicos para la producción de proteínas humanas]]></article-title>
<source><![CDATA[Anales de Veterinaria de Murcia]]></source>
<year>2014</year>
<volume>30</volume>
<page-range>7-18</page-range></nlm-citation>
</ref>
<ref id="B58">
<label>(58)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cruz]]></surname>
<given-names><![CDATA[M. P.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Conestat Alfa (Ruconest): First Recombinant C1 Esterase Inhibitor for the Treatment of Acute Attacks in Patients With Hereditary Angioedema]]></article-title>
<source><![CDATA[Pharmacy and Therapeutics]]></source>
<year>2015</year>
<volume>40</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>109-14</page-range></nlm-citation>
</ref>
<ref id="B59">
<label>(59)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lipozen&#269;i&#263;]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Wolf]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Life-threatening severe allergic reactions: urticaria, angioedema, and anaphylaxis]]></article-title>
<source><![CDATA[Clinics in Dermatology]]></source>
<year>2005</year>
<volume>23</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>193-205</page-range></nlm-citation>
</ref>
<ref id="B60">
<label>(60)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Shirley]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Sebelipase Alfa: First Global Approval]]></article-title>
<source><![CDATA[Drugs]]></source>
<year>2015</year>
<volume>75</volume>
<numero>16</numero>
<issue>16</issue>
<page-range>1935-40</page-range></nlm-citation>
</ref>
<ref id="B61">
<label>(61)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bornhorst]]></surname>
<given-names><![CDATA[J. A.]]></given-names>
</name>
<name>
<surname><![CDATA[Calderon]]></surname>
<given-names><![CDATA[F. R. O.]]></given-names>
</name>
<name>
<surname><![CDATA[Procter]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Tang]]></surname>
<given-names><![CDATA[W.]]></given-names>
</name>
<name>
<surname><![CDATA[Ashwood]]></surname>
<given-names><![CDATA[E. R.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Genotypes and serum concentrations of human alpha-1-antitrypsin &#8220;P&#8221; protein variants in a clinical population]]></article-title>
<source><![CDATA[Journal of Clinical Pathology]]></source>
<year>2007</year>
<volume>60</volume>
<numero>10</numero>
<issue>10</issue>
<page-range>1124-8</page-range></nlm-citation>
</ref>
<ref id="B62">
<label>(62)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Vinay]]></surname>
<given-names><![CDATA[D. S.]]></given-names>
</name>
<name>
<surname><![CDATA[Kwon]]></surname>
<given-names><![CDATA[B. S.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[4-1BB (CD137), an inducible costimulatory receptor, as a specific target for can cer therapy]]></article-title>
<source><![CDATA[BMB Reports]]></source>
<year>2014</year>
<volume>47</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>122-9</page-range></nlm-citation>
</ref>
<ref id="B63">
<label>(63)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pak]]></surname>
<given-names><![CDATA[V. N.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The use of alpha-fetoprotein for the treatment of autoinmune diseases and cancer]]></article-title>
<source><![CDATA[Therapeutic Delivery]]></source>
<year>2018</year>
<volume>9</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>37-46</page-range></nlm-citation>
</ref>
<ref id="B64">
<label>(64)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Raben]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
<name>
<surname><![CDATA[Plotz]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[Byrne]]></surname>
<given-names><![CDATA[B.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[&#8220;Acid a-Glucosidase Deficiency (Glycogenosis Type II, Pompe Disease)]]></article-title>
<source><![CDATA[Current Molecular Medicine]]></source>
<year>2002</year>
<volume>2</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>145-66</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
