<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0379-3982</journal-id>
<journal-title><![CDATA[Revista Tecnología en Marcha]]></journal-title>
<abbrev-journal-title><![CDATA[Tecnología en Marcha]]></abbrev-journal-title>
<issn>0379-3982</issn>
<publisher>
<publisher-name><![CDATA[Instituto Tecnológico de Costa Rica]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0379-39822019000400081</article-id>
<article-id pub-id-type="doi">10.18845/tm.v32i4.4794</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Control de calidad de fitofármacos con la utilización de Resonancia Magnética Nuclear (RMN) y la aplicación del análisis de componentes principales (PCA)]]></article-title>
<article-title xml:lang="en"><![CDATA[Quality control of phytopharmaceuticals with the use of Nuclear Magnetic Resonance (NMR) and the application of principal component analysis (PCA)]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Quesada-Espinoza]]></surname>
<given-names><![CDATA[Javier]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Murillo-Masís]]></surname>
<given-names><![CDATA[Renato]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Costa Rica Escuela de Química y CIPRONA ]]></institution>
<addr-line><![CDATA[San José ]]></addr-line>
<country>Costa Rica</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Costa Rica Escuela de Química y CIPRONA ]]></institution>
<addr-line><![CDATA[San José ]]></addr-line>
<country>Costa Rica</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2019</year>
</pub-date>
<volume>32</volume>
<numero>4</numero>
<fpage>81</fpage>
<lpage>94</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_arttext&amp;pid=S0379-39822019000400081&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_abstract&amp;pid=S0379-39822019000400081&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_pdf&amp;pid=S0379-39822019000400081&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen Los fitofármacos, aunque generalmente están compuestos de productos naturales, deben ser estrictamente controlados en cuando a su contenido de principios activos. Existen varios métodos de control de calidad entre los que se destacan la cromatografía líquida y la espectrometría de masas; en nuestra investigación llevamos a cabo un control de calidad con la utilización de Resonancia Magnética Nuclear, método el cual es de fácil utilización e interpretación, y altamente versátil, además de ser una técnica no destructiva, y consecuentemente un estudio de componentes principales para obtener una mejor visualización de los resultados. Lo que se logró demostrar es que en Costa Rica existe una gran cantidad de productos comercializados que aparentemente no contienen los principios activos que deberían tener de acuerdo al etiquetado, como pudo demostrarse en el caso de los productos de Gingko biloba, Hypericum perforatum y Silybum marianum. Para el caso de Equinacea spp, el problema de la comparación es que los diferentes productos contienen varias especies del mismo género y esto dificulta un análisis detallado. Además, el análisis de los componentes principales hizo posible demostrar que es difícil utilizar esta técnica sin un conocimiento previo de las técnicas de análisis utilizadas y qué debe interpretarse. Los resultados también indican que las regulaciones en Costa Rica no son lo suficientemente rigurosas para este tipo de productos, y estas deben ser revisadas por la Agencia Nacional Reguladora.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract The phytopharmaceuticals, although they are generally composed of natural products, must be strictly controlled regarding their content of active ingredients. There are several methods of quality control among which stand out liquid chromatography and mass spectrometry; in our research, we carried out a quality control with the use of Nuclear Magnetic Resonance, which is easy to use and interpret, and highly versatile, as well as non-destructive technique, and with this information a study of principal components was carried out in order to obtain a better visualization of the results. In this work we demonstrated that in Costa Rica there is a large number of products marketed that apparently do not contain the active ingredients that should have according to the labeling, as could be demonstrated in the case of the products of Gingko biloba, Hypericum perforatum and Silybum marianum. In the case of Equinacea spp, the problem of the comparison was that the different products contain several species of the same genus and this makes a detailed analysis difficult. In addition, the analysis of main components made it possible to demonstrate that it is difficult to use this technique without prior knowledge of the analysis techniques used, and what must to be interpreted. The results also indicate that regulations in Costa Rica are not rigorous enough for this type of products, and these should be reviewed by the National Regulatory Agency.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Fitofármacos]]></kwd>
<kwd lng="es"><![CDATA[Gingko biloba]]></kwd>
<kwd lng="es"><![CDATA[Hypericum perforatum]]></kwd>
<kwd lng="es"><![CDATA[Silybum marianum]]></kwd>
<kwd lng="es"><![CDATA[Equinacea]]></kwd>
<kwd lng="es"><![CDATA[Resonancia Magnética Nuclear]]></kwd>
<kwd lng="es"><![CDATA[Componentes Principales]]></kwd>
<kwd lng="es"><![CDATA[Control de calidad]]></kwd>
<kwd lng="en"><![CDATA[Phytopharmaceuticals]]></kwd>
<kwd lng="en"><![CDATA[Gingko biloba]]></kwd>
<kwd lng="en"><![CDATA[Hypericum perforatum]]></kwd>
<kwd lng="en"><![CDATA[Silybum marianum]]></kwd>
<kwd lng="en"><![CDATA[Echinacea]]></kwd>
<kwd lng="en"><![CDATA[Nuclear Magnetic Resonance]]></kwd>
<kwd lng="en"><![CDATA[Principal Components]]></kwd>
<kwd lng="en"><![CDATA[Quality control]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>(1)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Andlauer]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Fürst]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Nutraceuticals: a piece of history, present status and outlook]]></article-title>
<source><![CDATA[Food Res. Int]]></source>
<year>2002</year>
<volume>35</volume>
<page-range>171-6</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>(2)</label><nlm-citation citation-type="">
<collab>M. Intelligence</collab>
<source><![CDATA[&#8220;NUTRACEUTICALS MARKET - GROWTH, TRENDS, AND FORECAST (2019 - 2024)]]></source>
<year></year>
</nlm-citation>
</ref>
<ref id="B3">
<label>(3)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[S. Bishop]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Kao]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Xu]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Glucina]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Paterson]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Ferguson]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[From 2,000 years of Ganoderma luci dum to recent developments in]]></article-title>
<source><![CDATA[Phytochemistry]]></source>
<year>2015</year>
<volume>114</volume>
<page-range>56-65</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>(4)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Shahidi]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Nutraceuticals and functional foods: whole versus processed foods]]></article-title>
<source><![CDATA[Trends Food Sci]]></source>
<year>2009</year>
<volume>20</volume>
<page-range>376-87</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>(5)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Schilcher]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Kammerer]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Wegener]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Grundlegendes zur rationalen Phytotherapie]]></article-title>
<source><![CDATA[Leitfaden Phytotherapie]]></source>
<year>2007</year>
<page-range>1-30</page-range><publisher-loc><![CDATA[Jena, Elsevier, Urban &amp; Fischer ]]></publisher-loc>
</nlm-citation>
</ref>
<ref id="B6">
<label>(6)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Smith]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Jogalekar]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Gibson]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Regulation of natural health products in Canada]]></article-title>
<source><![CDATA[Regulation of natural health products in]]></source>
<year>2014</year>
<page-range>507-10</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>(7)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Coppens]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[da Silva]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Pettman]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[European regulations on nutraceuticals, dietary supplements, and functional foods: a framework based on safety]]></article-title>
<source><![CDATA[Toxicology 221]]></source>
<year>2006</year>
<page-range>59-74</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>(8)</label><nlm-citation citation-type="">
<collab>S. C. d. I. Jurídica</collab>
<source><![CDATA[]]></source>
<year></year>
</nlm-citation>
</ref>
<ref id="B9">
<label>(9)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Shen]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Du]]></surname>
<given-names><![CDATA[Q]]></given-names>
</name>
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Rapid separation and characterization of active flavonolignans of Silybum marianum by ultra-performance liquid chromatography coupled with electrospray tandem mass spectrometry]]></article-title>
<source><![CDATA[Journal of Pharmaceutical and Biomedical Analysis 53]]></source>
<year>2010</year>
<page-range>1053-7</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>(10)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[P. Minoja]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Napoli]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[NMR screening in the quality control of food and nutraceuticals]]></article-title>
<source><![CDATA[Food Research International]]></source>
<year>2014</year>
<volume>63</volume>
<page-range>126-31</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>(11)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[López-Gutiérrez]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Romero-González]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Martínez Vidal]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Garrido Frenich]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Quality control evalua tion of nutraceutical products from Ginkgo biloba sing liquid chromatography coupled to high resolution mass spectrometry]]></article-title>
<source><![CDATA[Journal of Pharmaceutical and Biomedical Analysis]]></source>
<year>2016</year>
<volume>121</volume>
<page-range>151-60</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>(12)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mai Le]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Milande]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Martineau]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Giraudeau]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Farjon]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Quantification of natural products in herbal supplements: A combined NMR approach applied on goldenseal]]></article-title>
<source><![CDATA[Journal of Pharmaceutical and Biomedical Analysis]]></source>
<year>2019</year>
<volume>165</volume>
<page-range>155-61</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>(13)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[H.-Y.]]></given-names>
</name>
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[Y.-Q.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The main active constituents and detoxification process of Ginkgo biloba seeds and their potential use in functional health foods]]></article-title>
<source><![CDATA[Journal of Food Composition and Analysis]]></source>
<year>2019</year>
<volume>83</volume>
</nlm-citation>
</ref>
<ref id="B14">
<label>(14)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Braquet]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Hosford]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Ethnopharmacology and the development of natural PAF antagonists as therapeu tic agents]]></article-title>
<source><![CDATA[J Ethnopharmacol]]></source>
<year>1994</year>
<volume>32</volume>
<page-range>122-3</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>(15)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Xiaoyan]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Chen]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Liu]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Ke]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Gong]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[Q]]></given-names>
</name>
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Fan]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Chemical analysis, pharmacologi cal activity and process optimization of the proportion of bilobalide and ginkgolides in Ginkgo biloba extract]]></article-title>
<source><![CDATA[Journal of Pharmaceutical and Biomedical Analysis]]></source>
<year>2018</year>
<volume>160</volume>
<page-range>46-54</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>(16)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[A. Pendry]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Kemp]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Hughes]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Freeman]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Nuhu]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Sanchez-Medina]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Corcoran]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Galante]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Silymarin content in Silybum marianum extracts as a biomarker for the quality of commercial tinctures]]></article-title>
<source><![CDATA[Journal of Herbal Medicine]]></source>
<year>2017</year>
<volume>10</volume>
<page-range>31-6</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>(17)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gazák]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Walterová]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Kren]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Silybin and silymarin-new and emerging applications in medicine]]></article-title>
<source><![CDATA[Curr Med Chem]]></source>
<year>2007</year>
<volume>14</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>315-38</page-range></nlm-citation>
</ref>
<ref id="B18">
<label>(18)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bruni]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Brighenti]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[K. Caesar]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Bertelli]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[B. Cech]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Pellati]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Analytical methods for the study of bioactive compounds from medicinally used Echinacea species]]></article-title>
<source><![CDATA[Journal of Pharmaceutical and Biomedical Analysis]]></source>
<year>2018</year>
<volume>160</volume>
<page-range>443-77</page-range></nlm-citation>
</ref>
<ref id="B19">
<label>(19)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Barnes]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Anderson]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Phillipson]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[St John&#8217;s wort (Hypericum perforatum L.): a review of its chemistry, pharmacology and clinical properties]]></article-title>
<source><![CDATA[J Pharm Pharmac]]></source>
<year>2001</year>
<page-range>53</page-range></nlm-citation>
</ref>
<ref id="B20">
<label>(20)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Todd]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Gulledge]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Britton]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Oberhofer]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Leyte-Lugo]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Moody]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Shymanovich]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Grubbs]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Juzumaite]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Graf]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Oberlies]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Faeth]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Laster]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Cech]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Ethanolic Echinacea purpurea Extracts Contain a Mixture of Cytokine-Suppressive and Cytokine-Inducing Compounds, Including Some That Originate from Endophytic Bacteria]]></article-title>
<source><![CDATA[PLoS ONE]]></source>
<year>2015</year>
<volume>10</volume>
<numero>5</numero>
<issue>5</issue>
</nlm-citation>
</ref>
<ref id="B21">
<label>(21)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[A. McKeown]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A review of the taxonomy of the genus Echinacea]]></article-title>
<source><![CDATA[Perspectives on new crops and new uses]]></source>
<year>1999</year>
<page-range>482-9</page-range><publisher-loc><![CDATA[Alexandria, VA, ASHS Press ]]></publisher-loc>
</nlm-citation>
</ref>
<ref id="B22">
<label>(22)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Tatsis]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Exarchou]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Troganis]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Gerothanassis]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[1H NMR determination of hypericin and pseudohy pericin in complex natural mixtures by the use of strongly deshielded OH groups]]></article-title>
<source><![CDATA[analytica chimica acta 607]]></source>
<year>2008</year>
<page-range>219-26</page-range></nlm-citation>
</ref>
<ref id="B23">
<label>(23)</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Napolitano]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Go&#776;decke]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Rodríguez-Brasco]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Jaki]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Chen]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Lankin]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Pauli]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The Tandem of Full Spin Analysis and qHNMR for the Quality Control of Botanicals Exemplified with Ginkgo biloba]]></article-title>
<source><![CDATA[J. Nat. Prod]]></source>
<year>2012</year>
<volume>75</volume>
<page-range>238&#8722;248</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
