<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0379-3982</journal-id>
<journal-title><![CDATA[Revista Tecnología en Marcha]]></journal-title>
<abbrev-journal-title><![CDATA[Tecnología en Marcha]]></abbrev-journal-title>
<issn>0379-3982</issn>
<publisher>
<publisher-name><![CDATA[Instituto Tecnológico de Costa Rica]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0379-39822016000400067</article-id>
<article-id pub-id-type="doi">10.18845/tm.v29i4.3038</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Identificación de secuencias génicas relacionadas con la ruta metabólica de síntesis de glicósidos en Stevia rebaudiana]]></article-title>
<article-title xml:lang="en"><![CDATA[Stevia rebaudiana genetic-sequences identification related with the glycosides synthesis pathway]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Jiménez-Quesada]]></surname>
<given-names><![CDATA[Karol]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Álvarez-Figueroa]]></surname>
<given-names><![CDATA[Adriana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Garro-Monge]]></surname>
<given-names><![CDATA[Giovanni]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Tecnológico de Cota Rica Centro de Investigación en Biotecnología (CIB) ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Costa Rica</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto Tecnológico de Cota Rica Centro de Investigación en Computación (CIC) ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Costa Rica</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Instituto Tecnológico de Cota Rica Centro de Investigación en Biotecnología (CIB) ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Costa Rica</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2016</year>
</pub-date>
<volume>29</volume>
<numero>4</numero>
<fpage>67</fpage>
<lpage>77</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_arttext&amp;pid=S0379-39822016000400067&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_abstract&amp;pid=S0379-39822016000400067&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_pdf&amp;pid=S0379-39822016000400067&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen Las plantas medicinales forman parte de la cultura de los pueblos desde tiempos inmemorables, pero los estudios sobre los procesos de síntesis de sus metabolitos secundarios son insuficientes. Por tanto, las tecnologías de transcriptómica y metabolómica han ganado credibilidad como opciones biológicamente más certeras para la caracterización del material vegetal, incluyendo estudios muy específicos en términos de expresión génica. Esta investigación tuvo por objetivo la búsqueda de genes de ruta de síntesis de glicósidos en Stevia rebaudiana, así como el análisis de regiones promotoras, para establecer relaciones entre sitios de interacción en el ADN y proteínas de anclaje reguladoras de la transcripción de Arabidopsis thaliana. Se secuenció una muestra de ARN mensajero a partir de tejidos de hoja de S. rebaudiana y se alineó contra las secuencias génicas reportadas. Algunos de los genes seleccionados se encontraron menos representados en el transcriptoma, lo que podría ser un indicador de la producción controlada de glicósidos regulada por ciertos genes; esto concuerda con los estudios correlativos, que han puesto de manifiesto la importancia de los genes SrCPPS, SrKS y SrKO en la regulación del contenido de glicósidos. El aprovechamiento de estos resultados involucra el estudio de los estímulos a los factores de transcripción que regulan la expresión génica dentro de la ruta metabólica de interés, como la respuesta al estrés hídrico y altos niveles de salinidad.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Medicinal plants are part of world culture since immemorial times, but studies about the processes of secondary-metabolites synthesis, are insufficient. Therefore, transcriptomics and metabolomics technologies have gained credibility as more accurate biologically options for characterization of plant material, including very specific studies in terms of gene expression. This research aimed to search in databases, glycosides synthesis pathway related genes in Stevia rebaudiana, and the analysis of promoter regions, to establish relationships between DNA interaction sites and transcription regulation proteins in Arabidopsis thaliana. A sample of mRNA was sequenced from S. rebaudiana leaf and was aligned against gene sequences reported. Some of the selected genes were found underrepresented in the transcriptome, which would signal the controlled production of glycosides regulated by certain genes; this is consistent with the correlative studies that have shown the importance of SrCPPS, SRKs, SrKO genes in regulating the content of glycosides. The use of these results involves the study of the stimuli to transcription factors that regulate gene expression in the metabolic pathway of interest, as the response to water stress and high levels of salinity.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Factor de transcripción]]></kwd>
<kwd lng="es"><![CDATA[glicósidos]]></kwd>
<kwd lng="es"><![CDATA[región promotora]]></kwd>
<kwd lng="es"><![CDATA[sitio de unión al ADN]]></kwd>
<kwd lng="es"><![CDATA[transcriptómica]]></kwd>
<kwd lng="en"><![CDATA[DNA binding site]]></kwd>
<kwd lng="en"><![CDATA[glycosides]]></kwd>
<kwd lng="en"><![CDATA[promoter region]]></kwd>
<kwd lng="en"><![CDATA[transcription factor]]></kwd>
<kwd lng="en"><![CDATA[transcriptomic]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Audesirk]]></surname>
<given-names><![CDATA[T.]]></given-names>
</name>
<name>
<surname><![CDATA[Audesirk]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
<name>
<surname><![CDATA[Byers]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Flores]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<source><![CDATA[Biología: la vida en la Tierra]]></source>
<year>2008</year>
<edition>8 ed</edition>
<publisher-loc><![CDATA[México D.F. ]]></publisher-loc>
<publisher-name><![CDATA[Prentice-Hall, Interamericana]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B2">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Carlberg]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Molnár]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<source><![CDATA[Mechanisms of Gene Regulation]]></source>
<year>2014</year>
<publisher-loc><![CDATA[Londres ]]></publisher-loc>
<publisher-name><![CDATA[Springer Science]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B3">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ceunen]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Geuns]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Spatio-temporal variation of the diterpene steviol in Stevia rebaudiana grown under different photoperiods]]></article-title>
<source><![CDATA[Phytochemistry]]></source>
<year>2013</year>
<volume>89</volume>
<page-range>32-8</page-range></nlm-citation>
</ref>
<ref id="B4">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Crispin]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Wurtele]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Use of Metabolomic and Transcriptomics to Gain Insights into the Regulation and Biosynthesis of Medicinal Compounds: Hypericum as a Model]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Chandra]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<source><![CDATA[Biotechnology for Medicinal Plants: Micropropagation and Improvement]]></source>
<year>2013</year>
<publisher-loc><![CDATA[Berlín ]]></publisher-loc>
<publisher-name><![CDATA[Springer]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B5">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Grabherr]]></surname>
<given-names><![CDATA[M.G.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Full-length transcriptome assembly from RNA-Seq data without a reference genome]]></article-title>
<source><![CDATA[Nature Biotechnology]]></source>
<year>2011</year>
<volume>29</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>644-53</page-range></nlm-citation>
</ref>
<ref id="B6">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Guleria]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[Kumar]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Identification of miR414 and Expression Analysis of Conserved miRNAs from Stevia rebaudiana]]></article-title>
<source><![CDATA[Genomics Proteomics Bioinformatics]]></source>
<year>2011</year>
<volume>9</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>211-7</page-range></nlm-citation>
</ref>
<ref id="B7">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Higo]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
<name>
<surname><![CDATA[Ugawa]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
<name>
<surname><![CDATA[Iwamoto]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Korenaga]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Plant cis-acting regulatory DNA elements (PLACE) database]]></article-title>
<source><![CDATA[Nucleic Acids Res]]></source>
<year>1999</year>
<volume>27</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>297-300</page-range></nlm-citation>
</ref>
<ref id="B8">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hornett]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[Wheat]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Quantitative RNA-Seq analysis in non-model species: assessing transcriptome assemblies as a scaffold and the utility of evolutionary divergent genomic reference species]]></article-title>
<source><![CDATA[BMC Genomics]]></source>
<year>2012</year>
<volume>13</volume>
<page-range>361-77</page-range></nlm-citation>
</ref>
<ref id="B9">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Karaköse]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
<name>
<surname><![CDATA[Rakesh]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Kuhnert]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Characterization and Quantification of Hydroxycinnamate Derivatives in Stevia rebaudiana Leaves by LC-MSn&#8224;.]]></article-title>
<source><![CDATA[Journal of Agricultural and Food Chemistry]]></source>
<year>2011</year>
<volume>59</volume>
<page-range>10143-50</page-range></nlm-citation>
</ref>
<ref id="B10">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kumar]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
<name>
<surname><![CDATA[Kaul]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
<name>
<surname><![CDATA[Bajpai-Gupta]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Kumar]]></surname>
<given-names><![CDATA[V.]]></given-names>
</name>
<name>
<surname><![CDATA[Kumar]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A comprehensive analysis of fifteen genes of steviol glycosides biosynthesis pathway in Stevia rebaudiana (Bertoni)]]></article-title>
<source><![CDATA[Gene]]></source>
<year>2012</year>
<volume>492</volume>
<page-range>276-84</page-range></nlm-citation>
</ref>
<ref id="B11">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kumar]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Guleria]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Steviol Glycosides from Stevia: Biosynthesis Pathway Review and their Application in Foods and Medicine]]></article-title>
<source><![CDATA[Critical Reviews in Food Science and Nutrition]]></source>
<year>2012</year>
<volume>52</volume>
<page-range>988-98</page-range></nlm-citation>
</ref>
<ref id="B12">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Latchman]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<source><![CDATA[Eucaryotic Transcripcion Factors]]></source>
<year>2003</year>
<edition>4</edition>
<publisher-loc><![CDATA[San Diego ]]></publisher-loc>
<publisher-name><![CDATA[Academic Press]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B13">
<nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lin]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<source><![CDATA[NGS Impacts and Key Concepts]]></source>
<year>2012</year>
</nlm-citation>
</ref>
<ref id="B14">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lohse]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Nunes-Nesi]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Krueger]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[Nagel]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Hannemann]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Giorgi]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
<name>
<surname><![CDATA[Childs]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[Osorio]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Walther]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[Selbig]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Sreenivasulu]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
<name>
<surname><![CDATA[Stitt]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Fernie]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Usadel]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Robin: An intuitive wizard application for R-based expression microarray quality assessment and analysis]]></article-title>
<source><![CDATA[Plant Physiology]]></source>
<year>2010</year>
<volume>153</volume>
<page-range>642-51</page-range></nlm-citation>
</ref>
<ref id="B15">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Muir]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Collins]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Robinson]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Hughes]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Bovy]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Ric De Vos]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Tunen]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Verhoeyen]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Overexpression of petunia chalcone isomerase in tomato results in fruit containing increased levels of flavonols]]></article-title>
<source><![CDATA[Natural Biotecnology]]></source>
<year>2001</year>
<volume>19</volume>
<page-range>470-4</page-range></nlm-citation>
</ref>
<ref id="B16">
<nlm-citation citation-type="">
<collab>Database of Plant Cis-acting Regulatory DNA Elements (PLACE)</collab>
<source><![CDATA[]]></source>
<year>2014</year>
</nlm-citation>
</ref>
<ref id="B17">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Puri]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Sharma]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[Tiwari]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Downstream processing of stevioside and its potential applications]]></article-title>
<source><![CDATA[Biotechnology Advances]]></source>
<year>2011</year>
<volume>29</volume>
<page-range>781-91</page-range></nlm-citation>
</ref>
<ref id="B18">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Schwechheimer]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Zourelidou]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Bevan]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Plant Transcription Factor Studies]]></article-title>
<source><![CDATA[Annu. Rev. Plant Physiol. Plant Mol. Biol]]></source>
<year>1998</year>
<volume>49</volume>
<page-range>127-50</page-range></nlm-citation>
</ref>
<ref id="B19">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sitakanta]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[Claire]]></surname>
<given-names><![CDATA[X.]]></given-names>
</name>
<name>
<surname><![CDATA[Kong]]></surname>
<given-names><![CDATA[Q.]]></given-names>
</name>
<name>
<surname><![CDATA[Shen]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
<name>
<surname><![CDATA[Yuan]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Directed evolution of plant basic helix-loop-helix transcription factors for the improvement of transactivational properties]]></article-title>
<source><![CDATA[Biochimica et Biophysica]]></source>
<year>2006</year>
<numero>1759</numero>
<issue>1759</issue>
<page-range>308-18</page-range></nlm-citation>
</ref>
<ref id="B20">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Trapnell]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Williams]]></surname>
<given-names><![CDATA[B.]]></given-names>
</name>
<name>
<surname><![CDATA[Pertea]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
<name>
<surname><![CDATA[Mortazavi]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Kwan G.]]></surname>
<given-names><![CDATA[van Baren]]></given-names>
</name>
<name>
<surname><![CDATA[M.]]></surname>
<given-names><![CDATA[Salzberg S.]]></given-names>
</name>
<name>
<surname><![CDATA[Wold]]></surname>
<given-names><![CDATA[B.]]></given-names>
</name>
<name>
<surname><![CDATA[Pachter]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Transcript assembly and quantication by RNA-Seq reveals unannotated transcripts and isoforms switching during cell differentiation]]></article-title>
<source><![CDATA[Nat Biotechnol]]></source>
<year>2010</year>
<volume>28</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>511-5</page-range></nlm-citation>
</ref>
<ref id="B21">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Urban]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Carakostas]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Brusick]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Steviol glycoside safety: Is the genotoxicity data base sufficient?]]></article-title>
<source><![CDATA[Food and Chemical Toxicology]]></source>
<year>2013</year>
<volume>51</volume>
<page-range>386-90</page-range></nlm-citation>
</ref>
<ref id="B22">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wölwer]]></surname>
<given-names><![CDATA[U]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The Leaves of Stevia rebaudiana (Bertoni). Their Constituents and the Analyses Thereof: A Review]]></article-title>
<source><![CDATA[J. Agric. Food Chem]]></source>
<year>2012</year>
<volume>60</volume>
<page-range>886-95</page-range></nlm-citation>
</ref>
<ref id="B23">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Overexpression analysis of plant transcription factors]]></article-title>
<source><![CDATA[Current Opinion in Plant Biology]]></source>
<year>2003</year>
<volume>6</volume>
<page-range>430-40</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
