<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0034-7744</journal-id>
<journal-title><![CDATA[Revista de Biología Tropical]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. biol. trop]]></abbrev-journal-title>
<issn>0034-7744</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Costa Rica]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0034-77442020000401241</article-id>
<article-id pub-id-type="doi">10.15517/rbt.v68i4.42094</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Berberina, curcumina y quercetina como potenciales agentes con capacidad antiparasitaria]]></article-title>
<article-title xml:lang="en"><![CDATA[Berberine, curcumin and quercetin as potential antiparasitic agents]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Elizondo-Luévano]]></surname>
<given-names><![CDATA[Joel-H.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hernández-García]]></surname>
<given-names><![CDATA[Magda-E.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pérez-Narváez]]></surname>
<given-names><![CDATA[Oscar-A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Castro-Ríos]]></surname>
<given-names><![CDATA[Rocío]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Chávez-Montes]]></surname>
<given-names><![CDATA[Abelardo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Autónoma de Nuevo León  ]]></institution>
<addr-line><![CDATA[ Nuevo León]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Autónoma de Nuevo León  ]]></institution>
<addr-line><![CDATA[ Nuevo León]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2020</year>
</pub-date>
<volume>68</volume>
<numero>4</numero>
<fpage>1241</fpage>
<lpage>1249</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_arttext&amp;pid=S0034-77442020000401241&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_abstract&amp;pid=S0034-77442020000401241&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_pdf&amp;pid=S0034-77442020000401241&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción: El uso indiscriminado de agentes antiparasitarios ha resultado en el establecimiento de resistencia a ellos. Por lo cual es necesario el desarrollo de nuevas alternativas de tratamiento. Los productos naturales poseen diversas cualidades como posibles coadyuvantes en terapias contra distintos agentes etiológicos, entre los que destaca sus efectos antiparasitarios.  Objetivo:  Evaluar la actividad antiparasitaria, antioxidante, citotóxica y citoprotectora de Berberina (Ber), Curcumina (Cur) y Quercetina (Qr).  Metodología:  Se prepararon soluciones de Ber, Cur y Qr grado analítico y se realizaron alícuotas a diferentes concentraciones para su evaluación en contra de: Entamoeba histolytica, Trichomonas vaginalis y Strongyloides venezuelensis, paraello, se determinó la concentración inhibitoria media (IC50), además se determinó la capacidad antioxidante (CE50) mediante la prueba de DPPH, ambos por la prueba de Probit. Mediante la técnica de hemólisis se determinó la actividad citotóxica y citoprotectora, se aplicó Anova y la prueba de Tukey para determinar la diferencia de las medias en los tratamientos evaluados.  Resultados:  Ber, Cur y Qr, presentaron actividad en contra de E. histolytica, T. vaginalis y S. venezuelensis in-vitro. Ber presentó IC50 de 1.7, 1.2 y 1.9 &#956;M respectivamente siendo más efectivo en comparación de Cur con IC50 de 55.3, 40.6 y 13.7 &#956;M o Qr con IC50 de 147.2, 93.2 y 110.9 &#956;M, sin embargo, la mejor actividad antioxidante (EC50 = 1.1 &#956;g/ml), citoprotectora y menos hemolítica, fue presentada por Qr (P &lt; 0.001) en comparación con el control evaluado.  Conclusiones: Los metabolitos de origen natural berberina, curcumina y quercetina, poseen actividad en contra de trofozoítos de E. histolytica, T. vaginalisy larvas de S. venezuelensis en dosis bajas comparables con los fármacos de referencia para el caso de Ber. Además, estos productos de origen natural, no sintético podrían ser objeto de futuras investigaciones para coadyuvar al tratamiento de parasitosis, ya que, en dosis bajas, mostraron actividad antioxidante sin mostrar hemólisis considerable en eritrocitos humanos.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction: The indiscriminate use of antiparasitic agents has resulted in the establishment of resistance to them. Therefore, the development of new treatment alternatives is necessary. Natural products have various qualities as possible adjuvants in therapies against different etiological agents, among which its antiparasitic effects stand out.  Objective:  To evaluate the antiparasitic, antioxidant, cytotoxic, and cytoprotective activity of Berberine (Ber), Curcumin (Cur), and Quercetin (Qr).  Methods: Analytical grade Ber, Cur, and Qr solutions were prepared, and aliquots were made at different concentrations for their evaluation against Entamoeba histolytica, Trichomonas vaginalis, and Strongyloides venezuelensis. To do this, the mean inhibitory concentration (IC50) was determined, and the antioxidant capacity (EC50) was also determined by the DPPH assay, both using the Probit statistical test. The cytotoxic and cytoprotective activity was determined by the hemolysis technique, Anova and Tukey&#8217;s test were applied to determine the difference in the means in the treatments evaluated.  Results: Ber, Cur, and Qr, showed activity against E. histolytica, T. vaginalis, and S. venezuelensisin-vitro. Ber presented IC50 of 1.7, 1.2, and 1.9 &#956;M respectively, being more effective compared to Cur with IC50 of 55.3, 40.6, and 13.7 &#956;M, or Qr with IC50 of 147.2, 93.2, and 110.9 &#956;M, however, the best antioxidant activity (EC50 = 1.1 &#956;g/ml), cytoprotective and less hemolytic, was presented by Qr (P &lt; 0.001) compared to the evaluated control.  Conclusions: The metabolites of natural origin berberine, curcumin, and quercetin, have activity against trophozoites of E. histolytica, T. vaginalis and larvae of S. venezuelensis in low doses comparable to the reference drugs in the case of Ber. Furthermore, these non-synthetic products of natural origin could be the subject of future research to help treat parasitosis, since in low doses, they showed antioxidant activity without showing considerable cytotoxicity in human erythrocytes.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[antiparasitic activity]]></kwd>
<kwd lng="en"><![CDATA[antiparasitics]]></kwd>
<kwd lng="en"><![CDATA[berberine]]></kwd>
<kwd lng="en"><![CDATA[curcumin]]></kwd>
<kwd lng="en"><![CDATA[quercetin]]></kwd>
<kwd lng="es"><![CDATA[actividad antiparasitaria]]></kwd>
<kwd lng="es"><![CDATA[antiparasitarios]]></kwd>
<kwd lng="es"><![CDATA[berberina]]></kwd>
<kwd lng="es"><![CDATA[curcumina]]></kwd>
<kwd lng="es"><![CDATA[quercetina]]></kwd>
</kwd-group>
</article-meta>
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