<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0001-6002</journal-id>
<journal-title><![CDATA[Acta Médica Costarricense]]></journal-title>
<abbrev-journal-title><![CDATA[Acta méd. costarric]]></abbrev-journal-title>
<issn>0001-6002</issn>
<publisher>
<publisher-name><![CDATA[Colegio de Médicos y Cirujanos de Costa Rica]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0001-60022022000100058</article-id>
<article-id pub-id-type="doi">10.51481/amc.v64i1.1221</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Ciencia básica y sus aplicaciones: tres hitos en el siglo XXCon especial referencia a la Hidratación Oral]]></article-title>
<article-title xml:lang="en"><![CDATA[Basic science and its applications: three milestones in the 20th century with special reference to Oral Rehydration]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[De Céspedes-Montealegre]]></surname>
<given-names><![CDATA[Carlos]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Colegio de Médicos y Cirujanos de Costa Rica Academia Nacional de Medicina de Costa Rica ]]></institution>
<addr-line><![CDATA[San José ]]></addr-line>
<country>Costa Rica</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2022</year>
</pub-date>
<volume>64</volume>
<numero>1</numero>
<fpage>58</fpage>
<lpage>63</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_arttext&amp;pid=S0001-60022022000100058&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_abstract&amp;pid=S0001-60022022000100058&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_pdf&amp;pid=S0001-60022022000100058&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen Tras el descubrimiento de que el transporte del sodio y el transporte de la glucosa están acoplados en el intestino delgado, de manera que la glucosa acelera la absorción de soluto y agua, destacó la hidratación oral junto con otros hitos del siglo XX como el desarrollo de la penicilina y los cultivos virales que anteceden la vacuna contra la poliomielitis; este artículo de opinión se refiere a la participación de Costa Rica en el exitoso desarrollo de un estudio de investigación aplicada sobre un problema prioritario de Salud: la hidratación oral en las diarreas provocadas por virus.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Following the discovery that sodium transport and glucose transport are coupled in the small intestine, such that glucose accelerates solute and water absorption, highlighted oral hydration), along with other 20th-century milestones like the development of penicillin and viral cultures that preceded the polio vaccine; this opinion article refers to the participation of Costa Rica in the successful development of an applied research study on a priority health problem: oral rehydration in diarrhea caused by viruses.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[diarrea]]></kwd>
<kwd lng="es"><![CDATA[rehidratación oral]]></kwd>
<kwd lng="es"><![CDATA[rotavirus]]></kwd>
<kwd lng="es"><![CDATA[absorción intestinal]]></kwd>
<kwd lng="en"><![CDATA[diarrhea]]></kwd>
<kwd lng="en"><![CDATA[oral rehydration]]></kwd>
<kwd lng="en"><![CDATA[rotavirus]]></kwd>
<kwd lng="en"><![CDATA[intestinal absorption]]></kwd>
</kwd-group>
</article-meta>
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