<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0001-6002</journal-id>
<journal-title><![CDATA[Acta Médica Costarricense]]></journal-title>
<abbrev-journal-title><![CDATA[Acta méd. costarric]]></abbrev-journal-title>
<issn>0001-6002</issn>
<publisher>
<publisher-name><![CDATA[Colegio de Médicos y Cirujanos de Costa Rica]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0001-60022022000100020</article-id>
<article-id pub-id-type="doi">10.51481/amc.v64i1.1136</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Variación en un solo nucleótido en genes de citocinas como marcadores de enfermedades]]></article-title>
<article-title xml:lang="en"><![CDATA[Single nucleotide variation in cytokine genes as disease markers]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Betancourth-Arteaga]]></surname>
<given-names><![CDATA[Isabella]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodriguez-Patiño]]></surname>
<given-names><![CDATA[Erika]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fabián-Gómez]]></surname>
<given-names><![CDATA[Romel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Chávez-Vivas]]></surname>
<given-names><![CDATA[Mónica]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Libre Seccional Cali Facultad Ciencias de la Salud Programa de Medicina]]></institution>
<addr-line><![CDATA[Cali ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Libre Seccional Cali Facultad Ciencias de la Salud Programa de Medicina, Cali]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad Libre Seccional Cali Facultad de Ciencias de la Salud Departamento de Ciencias Básicas Biomédicas]]></institution>
<addr-line><![CDATA[Cali, ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidad Libre Seccional Cali Facultad de Ciencias de la Salud ]]></institution>
<addr-line><![CDATA[Cali ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2022</year>
</pub-date>
<volume>64</volume>
<numero>1</numero>
<fpage>20</fpage>
<lpage>33</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_arttext&amp;pid=S0001-60022022000100020&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_abstract&amp;pid=S0001-60022022000100020&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_pdf&amp;pid=S0001-60022022000100020&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Objetivo:  Describir la asociación de las variantes en los genes que codifican por citocinas participantes en el proceso inflamatorio con la susceptibilidad y la gravedad clínica de las enfermedades.  Métodos:  Se realizó un estudio documental con revisión de literatura científica encontrada en las siguientes bases de datos: Pubmed, Science Direct, Scopus, Scielo, PLOS, Hinari, Redalyc, Dialnet, Taylor, ProQuest. Se revisaron 84 referencias relacionadas con artículos de investigación, revisiones sistemáticas y metaanálisis con los términos ''variante'', ''variante en un solo nucléotido'', ''polimorfismo de nucleótido único'', ''citocinas proinflamatorias'', ''citocinas antiinflamatorias'', ''interleucinas'', ''factor de necrosis tumoral'', ''susceptibilidad genética'', ''enfermedades'' y ''patologías''.  Resultados:  La evidencia señala que las variantes en un solo nucleótido se detectan principalmente en regiones promotoras de genes que codifican para citocinas reguladoras de procesos inflamatorios, como son: IL-1, IL-6, IL-8, IL-10, IL-12, IL-17, IL-18, IL-22 y el factor de necrosis tumoral.  Conclusiones:  La expresión y la producción diferencial de estas citocinas desempeñan un papel relevante en la patogenia y la predisposición a sufrir enfermedades, especialmente metabólicas, malignas, autoinmunes e infecciosas. Se mostró también un efecto diferencial de las variantes según las características étnicas, lo que resulta ser una herramienta eficaz en la medicina preventiva.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Aim: To describe the association of variations in cytokine genes that participate in the inflammatory process with the susceptibility and clinical severity of diseases.  Methods:  A documentary study was carried out with a review of the scientific literature of the database: Pubmed, Science Direct, Scopus, Scielo, PLOS, Hinari, Redalyc, Dialnet, Taylor, ProQuest. Eighty-four references were reviewed that included research articles, systematic reviews and meta-analyzes, using the terms ''Variants'', ''Single Nucleotide Variation'', ''Proinflammatory cytokines'', ''Anti-inflammatory cytokines'', ''Interleukins'', ''Tumor Necrosis Factor'', ''genetic susceptibility'', ''diseases'', pathologies''.  Results:  The evidence indicates that Single Nucleotide Variants are detected mainly in promoter regions of genes that code for cytokines that regulate inflammatory processes such as: IL-1, IL-6, IL-8, IL-10, IL-12, IL -17, IL-18, IL-22 and tumoral necrosis factor.  Conclusions:  The expression and differential production of these cytokines play a role in the pathogenesis and predisposition to diseases, especially metabolic, malignant, autoimmune, and infectious. A differential effect of variants according to ethnic characteristics is also observed, which turns out to be an effective tool to be used in preventive medicine.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[citocinas]]></kwd>
<kwd lng="es"><![CDATA[interleucina]]></kwd>
<kwd lng="es"><![CDATA[factor de necrosis tumoral]]></kwd>
<kwd lng="es"><![CDATA[variación de un solo nucleótido]]></kwd>
<kwd lng="es"><![CDATA[polimorfismo de nucleótido único]]></kwd>
<kwd lng="es"><![CDATA[susceptibilidad a enfermedades]]></kwd>
<kwd lng="en"><![CDATA[Cytokines]]></kwd>
<kwd lng="en"><![CDATA[interleukin]]></kwd>
<kwd lng="en"><![CDATA[tumor necrosis factor]]></kwd>
<kwd lng="en"><![CDATA[single nucleotide variation]]></kwd>
<kwd lng="en"><![CDATA[single nucleotide polymorphism]]></kwd>
<kwd lng="en"><![CDATA[disease susceptibility]]></kwd>
</kwd-group>
</article-meta>
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