<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0001-6002</journal-id>
<journal-title><![CDATA[Acta Médica Costarricense]]></journal-title>
<abbrev-journal-title><![CDATA[Acta méd. costarric]]></abbrev-journal-title>
<issn>0001-6002</issn>
<publisher>
<publisher-name><![CDATA[Colegio de Médicos y Cirujanos de Costa Rica]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0001-60022021000400199</article-id>
<article-id pub-id-type="doi">10.51481/amc.v63i4.1212</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Activación inmune por productos finales de glicación avanzada]]></article-title>
<article-title xml:lang="en"><![CDATA[Immune activation by advanced glycation endproducts]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Centeno-Ureña]]></surname>
<given-names><![CDATA[Yadel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ulloa-Morales]]></surname>
<given-names><![CDATA[Alejandro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Caja Costarricense de Seguro Social  ]]></institution>
<addr-line><![CDATA[San José ]]></addr-line>
<country>Costa Rica</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto Max Planck para Fisiología Molecular  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Alemania</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<volume>63</volume>
<numero>4</numero>
<fpage>199</fpage>
<lpage>209</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_arttext&amp;pid=S0001-60022021000400199&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_abstract&amp;pid=S0001-60022021000400199&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_pdf&amp;pid=S0001-60022021000400199&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen Con el objetivo de revisar los avances recientes en la biología de los productos de glica- ción avanzada y su papel en diversas patologías de alta relevancia en salud pública, se realizó una búsqueda dirigida de la bibliografía entre los años 2000 al 2021 en la base de datos PubMed (NCBI) y se usaron como palabras clave &#8220;advanced glycation end pro- ducts&#8221;. Se ha demostrado que el receptor de productos de glicación avanzada induce una activación sostenida del factor de transcripción proinflamatorio NF-kB y suprime una serie de funciones autorreguladoras endógenas. Este efecto influye negativamente en una gran variedad de patologías como diabetes, autoinmunidad, neurodegeneración y enfermedades infecciosas. La acumulación tisular de productos de glicación avanzada está relacionada con procesos de inflamación crónica y disfunción celular, y constituye un blanco prometedor para el diseño de tratamientos enfocados en esta vía de señali- zación. Actualmente se realizan múltiples ensayos clínicos para determinar su utilidad como marcador de lesiones pulmonares en COVID-19.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract To review recent advances in the biology of advanced glycation endproducts and its role in diverse pathologies of high relevance for public health, a survey of the literature from the years 2000 to 2021 was performed in PubMed (NCBI) using the key words &#8220;advanced glycation endproducts&#8221;. It has been demonstrated that the receptor for advanced glyca- tion endproducts (RAGE) induces a sustained activation of the pro-inflammatory tran- scription factor NF-kB and suppresses a series of endogenous self-regulating functions. This affects negatively on a wide variety of pathological conditions such as diabetes, au- toimmunity, neurodegeneration and infectious disease. Tissular accumulation of AGEs is linked to chronic inflammation and cellular dysfunction and constitutes a promising target for the design of treatments focused on this signaling pathway. Multiple clinical trials are currently underway to define its usefulness as a marker of pulmonary lesions in COVID-19.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[diabetes]]></kwd>
<kwd lng="es"><![CDATA[neurodegeneración]]></kwd>
<kwd lng="es"><![CDATA[glicación avanzada]]></kwd>
<kwd lng="es"><![CDATA[receptor para productos finales de glicación avanzada]]></kwd>
<kwd lng="es"><![CDATA[COVID-19.]]></kwd>
<kwd lng="en"><![CDATA[diabetes]]></kwd>
<kwd lng="en"><![CDATA[neurodegeneration]]></kwd>
<kwd lng="en"><![CDATA[advanced glycation]]></kwd>
<kwd lng="en"><![CDATA[receptor for advanced glycation end products]]></kwd>
<kwd lng="en"><![CDATA[COVID-19]]></kwd>
</kwd-group>
</article-meta>
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