<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0001-6002</journal-id>
<journal-title><![CDATA[Acta Médica Costarricense]]></journal-title>
<abbrev-journal-title><![CDATA[Acta méd. costarric]]></abbrev-journal-title>
<issn>0001-6002</issn>
<publisher>
<publisher-name><![CDATA[Colegio de Médicos y Cirujanos de Costa Rica]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0001-60022021000200138</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Caso clínico: Paciente doble heterocigoto para Hemoglobina New York (HB Kaohsiung) y Alfa Talasemia (-&#945;3.7/&#945;&#945;)]]></article-title>
<article-title xml:lang="en"><![CDATA[en]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pérez-Rodríguez]]></surname>
<given-names><![CDATA[Vivian]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Alvarado-Romero]]></surname>
<given-names><![CDATA[Danny]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cartín-Sánchez]]></surname>
<given-names><![CDATA[Walter]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Caja Costarricense de Seguro Social Laboratorio Clínico Área de Salud de Aserrí ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Costa Rica</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Caja Costarricense del Seguro Social Hospital Nacional de Niños Dr. Carlos Sáenz Herrera Laboratorio de Tamizaje Neonatal y Alto Riesgo]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Costa Rica</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Caja Costarricense del Seguro Social Hospital Nacional de Niños Dr. Carlos Sáenz Herrera Laboratorio de Estudios Especializados e Investigación]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Costa Rica</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2021</year>
</pub-date>
<volume>63</volume>
<numero>2</numero>
<fpage>138</fpage>
<lpage>141</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_arttext&amp;pid=S0001-60022021000200138&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_abstract&amp;pid=S0001-60022021000200138&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_pdf&amp;pid=S0001-60022021000200138&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen Se reporta el caso de una paciente adulta, asintomática, sin historial familiar de anemia o enfermedades crónicas, atendida en el Laboratorio Clínico del Área de Salud de Aserrí que acude a control salud por seguimiento a tratamiento de anemia. Se revisa el histórico del expediente médico del propositus, donde se evidencia que el VCM por debajo del límite de referencia normal, hace incurrir al médico tratante en el error de asociar microcitosis con anemia ferropriva. Sin embargo, el Laboratorio Clínico de Aserrí cuenta con un algoritmo de donde se deriva que los índices y la morfología obtenidos en este hemograma son sugestivos de Talasemia, por lo que se envía la muestra al Laboratorio de Estudios Especializados e Investigación del Hospital Nacional de Niños Dr. Carlos Sáenz Herrera para realizar una electroforesis de hemoglobina. En este análisis se detecta una variante de hemoglobina. A nuestro buen saber, no se ha descrito anteriomente un caso de doble heterocigota como el aquí mencionado, por lo que se reporta el primer caso en Costa Rica de un doble heterocigota hemoglobina New York/-3.7 Alfa Talasemia.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract An asymptomatic adult female, with no previous family history of anemia or chronic diseases, goes to consultation at Aserrí 's Clínic for anemia follow up. A history review of the medical record shows that MCV is below the lower reference range. This MCV value induces the physician to treat the patient for iron deficiency anemia. Using the algorithm of the Clinical Laboratory in Aserrí, such erythrocytic indices are suggestive of Thalassemia. For these reason a blood sample is sent for hemoglobin electrophoresis and molecular analysis at the specialized hematology laboratory at the National Children's Hospital. A variant hemoglobin is detected. To our knowledge, this is the first case of compound heterozygous for Hemoglobin New York/-3.7 Alfa Thalassemia in Costa Rica.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Hemoglobina New York]]></kwd>
<kwd lng="es"><![CDATA[hemoglobina Kaohsiung]]></kwd>
<kwd lng="es"><![CDATA[alfa talasemia]]></kwd>
<kwd lng="es"><![CDATA[índices hematimétricos]]></kwd>
<kwd lng="es"><![CDATA[anemia]]></kwd>
<kwd lng="en"><![CDATA[hemoglobin New York]]></kwd>
<kwd lng="en"><![CDATA[hemoglobin Kaohsiung]]></kwd>
<kwd lng="en"><![CDATA[alpha thalassemia]]></kwd>
<kwd lng="en"><![CDATA[red cells indices]]></kwd>
<kwd lng="en"><![CDATA[anemia]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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