<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0001-6002</journal-id>
<journal-title><![CDATA[Acta Médica Costarricense]]></journal-title>
<abbrev-journal-title><![CDATA[Acta méd. costarric]]></abbrev-journal-title>
<issn>0001-6002</issn>
<publisher>
<publisher-name><![CDATA[Colegio de Médicos y Cirujanos de Costa Rica]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0001-60022019000400142</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Actualización en plasma rico en plaquetas]]></article-title>
<article-title xml:lang="en"><![CDATA[Platelet rich plasma update]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Castro-Piedra]]></surname>
<given-names><![CDATA[Silvia E.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Arias-Varela]]></surname>
<given-names><![CDATA[Karla A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Tecnológico de Costa Rica, ITCR Centro de Investigación en Biotecnología ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<aff id="Af2">
<institution><![CDATA[,Centro de Excelencia de Investigación de Terapias de Avanzada, CEITA.  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2019</year>
</pub-date>
<volume>61</volume>
<numero>4</numero>
<fpage>142</fpage>
<lpage>151</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_arttext&amp;pid=S0001-60022019000400142&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_abstract&amp;pid=S0001-60022019000400142&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_pdf&amp;pid=S0001-60022019000400142&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen El plasma rico en plaquetas es un producto derivado de la sangre, rico en péptidos y proteínas de señalización intercelular, así como citoquinas capaces de intervenir en cada una de las etapas de la regeneración de varios tejidos. Principalmente, se le han atribuido efectos antiinflamatorios en diferentes lesiones, así como otros efectos biológicos sobre las células y tejidos. A la fecha, no existe un protocolo estándar de producción o preparación, tampoco se ha descrito una dosis específica; la forma de aplicación es muy variable y depende de la condición por tratar. A pesar de ello, se han visto efectos positivos en campos como: odontología, ortopedia, dermatología, medicina reconstructiva, oftalmología, medicina deportiva, medicina vascular, entre otros. Su regulación es muy diversa a nivel internacional. Aunque hay expectativas con el tratamiento de plasma rico en plaquetas, no hay suficientes ensayos clínicos robustos que brinden un alto nivel de evidencia para validarlo como un tratamiento de rutina frente a determinada condición clínica. Además, no se pueden comparar fácilmente los resultados de diferentes investigaciones, por la variabilidad en el método de preparación y por la falta de homogeneidad en las lesiones tratadas, entre otros factores. Es por lo anterior que resulta necesario desarrollar más investigaciones serias que conlleven al establecimiento de un protocolo estandarizado, así como demostrar la efectividad de este nuevo tratamiento, de forma que se culmine con la implementación de nuevas terapias validadas y autorizadas para garantizar una mejoría real a los pacientes.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Platelet-rich plasma is a blood-derived product, rich in peptides and intercellular signaling proteins and cytokines capable of intervening in each stage of the regeneration of various tissues. Mainly, it has been attributed anti-inflammatory effects in different lesions, as well as other biological effects on cells and tissues. To date, there is no standard production or preparation protocol, nor has a specific dose been described. The form of application is very variable and depends on the condition to be treated. Despite this, positive effects have been seen in different fields such as: dentistry, orthopedics, dermatology, reconstructive medicine, ophthalmology, sports medicine, vascular medicine among others. Its regulation is very diverse internationally. Although there is a lot of expectation with the treatment of platelet-rich plasma, there are not enough robust clinical trials that provide a high level of evidence to validate it as a routine treatment for a certain clinical condition. In addition, the results of different investigations cannot be easily compared due to the variability in the method of preparation and the lack of homogeneity in the treated lesions, among other factors. It is for this reason that it is necessary to develop more serious investigations that lead to the establishment of a standardized protocol, as well as to demonstrate the effectiveness of this new treatment and culminate with the implementation of new validated and authorized therapies to guarantee a real improvement to the patients.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[plasma rico en plaquetas]]></kwd>
<kwd lng="es"><![CDATA[péptidos y proteínas de señalización intercelular]]></kwd>
<kwd lng="es"><![CDATA[dermatología]]></kwd>
<kwd lng="es"><![CDATA[regeneración]]></kwd>
<kwd lng="es"><![CDATA[sistema músculo-esquelético.]]></kwd>
<kwd lng="en"><![CDATA[platelet-rich plasma]]></kwd>
<kwd lng="en"><![CDATA[peptides and intercellular signaling proteins]]></kwd>
<kwd lng="en"><![CDATA[dermatology]]></kwd>
<kwd lng="en"><![CDATA[regeneration]]></kwd>
<kwd lng="en"><![CDATA[musculoskeletal system.]]></kwd>
</kwd-group>
</article-meta>
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