<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0001-6002</journal-id>
<journal-title><![CDATA[Acta Médica Costarricense]]></journal-title>
<abbrev-journal-title><![CDATA[Acta méd. costarric]]></abbrev-journal-title>
<issn>0001-6002</issn>
<publisher>
<publisher-name><![CDATA[Colegio de Médicos y Cirujanos de Costa Rica]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0001-60022017000200060</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Aislamiento de componentes y efecto hipoglicemiante del extracto metanólico de albahaca (Ocium basilicum), en ratas C57bl/6 con hiperglicemia experimental]]></article-title>
<article-title xml:lang="en"><![CDATA[Isolation of components and hypoglycemic effect of methanolic basil extract (ocium basilicum) in C57bl/6 rats with experimental hyperglycemia]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Meléndez-Jimenez]]></surname>
<given-names><![CDATA[Manuel Alejandro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rivero-Cuevas]]></surname>
<given-names><![CDATA[Ángel Raúl]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vivas-Pivat]]></surname>
<given-names><![CDATA[Isis Helga]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Naylander- Lugo]]></surname>
<given-names><![CDATA[Gustavo Adolfo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,aff1  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<aff id="Af2">
<institution><![CDATA[,aff2  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad Central de Venezuela  ]]></institution>
<addr-line><![CDATA[Aragua Maracay]]></addr-line>
<country>Venezuela</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2017</year>
</pub-date>
<volume>59</volume>
<numero>2</numero>
<fpage>60</fpage>
<lpage>66</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_arttext&amp;pid=S0001-60022017000200060&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_abstract&amp;pid=S0001-60022017000200060&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.sa.cr/scielo.php?script=sci_pdf&amp;pid=S0001-60022017000200060&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Antecedentes: La albahaca (Ocium basilicum) es una hierba perteneciente a la familia laminaceae, caracterizada por sus bondades medicinales. Se ha referido su uso en la terapéutica del cáncer, vitíiigo, hipercolesterolemia y la diabetes mellitus.  Objetivo: Evaluar el efecto hipoglicemiante del extracto metanólico de la albahaca, su aislamiento y purificación de sus principales compuestos.  Métodos: Las hojas y tallos fueron colectadas en el sector la Hechicera, estado Mérida, Venezuela. Las muestras se maceraron en 20L de metanol al 70% v/v, dosificándose a dosis crecientes entre 1,0 y 2,0 g/kg, usando como modelo experimental, ratas macho de la cepa C57BL/6, con hiperglicemia inducida con aloxano monohidratado. Se incluyó un control positivo usando como agente hipoglucemiante la sitagliptina (400&#956;g/kg). El extracto se sometió a fraccionamiento mediante cromatografía de columna abierta, cuyas fracciones (175 ml cada una) se asociaron por similitud estructural y fueron dosificadas a la población en estudio. Se obtuvieron muestras sanguíneas seriadas de la vena de la base de la cola y se procesaron siguiendo el método de la glucosa oxidasa-peroxidasa.  Resultados: Se demostró una disminución de la concentración de glucosa sanguínea a la dosis de 2,0 g/kg (&lt;120 mg/dL). Los análisis estructurales se realizaron mediante pruebas cromatográficas, espectroscópicas, espectrométricas y químicas. Del estudio se aislaron e identificaron los siguientes compuestos: nandecilato de metilo (C20O2H40); behenato de metilo (C23O2H46) hexacosanoato de metilo(C27O2H54), así como 18-metoxicarbonil-3,4-didehidroibogamina, el flavonoides 5,7,3´-trihydroxi-3,6,4´-trimetoxiflavona, los cuales son reportados por primera vez en los análisis fitoquímicos para O. basilicum.  Conclusión: Estos hallazgos sustentan el potencial uso de la albahaca como alternativa considerable en el tratamiento hipoglucemiante.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Background: Basil (Ocium basilicum) is an herb belonging to the family laminaceae, characterized by its medicinal benefits. Its use has been referred for the treatment of cancer, vitiligo, hypercholesterolemia, and diabetes mellitus.  Objective: To evaluate the hypoglycemic effect of the methanol extract of basil, isolation and purification of its main compounds.  Methods: The leaves and stems were collected in the sector La Hechicera, Mérida, Venezuela State. Samples were macerated in 20L of methanol to 70% v/v, dosing to increaseddoses between 1.0 and2.0 g/kg, using as experimental model, male rats of the C57BL/6 strain with hyperglycemia induced with alloxan monohydrate. A positivecontrol was included using as a hypoglycemic agent sitagliptin (400&#956;g/kg). The extract was submitted to fractionation by open column chromatography,, whose fractions (175 ml each) were partnered by structural similarity and were dosed to the population under study. Serial blood samples from the base of the tail vein were obtained and were processed using the method of the glucose oxidase-peroxidase.  Results: They showed a decrease of the concentration of blood glucose at a dose of 2.0 g/kg (&amp;lt; 120 mg/dL). Structural analyses were conducted using chromatographic, spectroscopic, spectrometric and chemical tests. They were isolated from the study and the following compounds were identified: nandecilato of methyl (C20O2H40); methyl behenate (C23O2H46), methyl hexacosanoate (C27O2H54) as well as 18-methoxycarbonyl-3, 4-didehidroibogamina, 5,7,3´-trihydroxi-3,6,4´- trimetoxiflavona flavonoid, which are reported for the first time in the phytochemical analysis for O. basilicum.  Conclusion: These findings support the potential use of Basil as a weed of traditional medicine in the hypoglycemic treatment.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[diabetes mellitus]]></kwd>
<kwd lng="es"><![CDATA[hiperglicemia]]></kwd>
<kwd lng="es"><![CDATA[ratas]]></kwd>
<kwd lng="es"><![CDATA[hipoglucémico]]></kwd>
<kwd lng="es"><![CDATA[medicina natural]]></kwd>
<kwd lng="es"><![CDATA[farmacología]]></kwd>
<kwd lng="en"><![CDATA[Mellitus diabetes]]></kwd>
<kwd lng="en"><![CDATA[hyperglycemia, rats, hypoglycemic]]></kwd>
<kwd lng="en"><![CDATA[natural medicine, pharmacology]]></kwd>
</kwd-group>
</article-meta>
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