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Revista Costarricense de Cardiología

Print version ISSN 1409-4142

Abstract

REALES FIGUEROA, Dr. Pedro et al. Proteína C Reactiva en el pronóstico de la insuficiencia cardiaca. Rev. costarric. cardiol [online]. 2007, vol.9, n.2, pp.5-10. ISSN 1409-4142.

Introduction. Heart failure is a complex syndrome in which many factors are implicated, such as neurohormones with oxygen free radicals and markers of inflammation activation such as C -reactive protein (CRP). Despite significant advances in treatment strategies the prognosis is poor and difficult to predict, different biomarkers (hormones, markers of cellular injury and inflammation, cytokines and antigens) have been shown to serve as independent prognostic indicators, in both the short and long term heart failure patient. Objectives. To find out the proinflammatory state of patients with this syndrome, determining if CRP levels have prognostic value for mortality and during hospitalisation and to find out the relationship between CRP levels and NYHA functional classes I-IV. Methods. All 180 consecutive patients that were admitted to our service during a one year period with the diagnosis of heart failure, were prospectively enrolled. We look for differences in CPR levels between survivors and no survivors, regarding days of hospitalization and between different NYHA functional class groups. Results. We observed statistically significant differences between CRP levels regarding mortality and during hospitalisation, but only between NYHA classes I -II vs III - IV. Conclusion. At the present time, there is insufficient evidence available to enable the markers to be incorporated into routine clinical practice, current data must be validated in future prospective studies.

Keywords : Heart failure; C-reactive protein; Prognosis.

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